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Adipokines and Arterial Stiffness in Obesity

Adipokines are active molecules with pleiotropic effects produced by adipose tissue and involved in obesity-related metabolic and cardiovascular diseases. Arterial stiffness, which is a consequence of arteriosclerosis, has been shown to be an independent predictor of cardiovascular morbidity and mor...

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Detalles Bibliográficos
Autores principales: Para, Ioana, Albu, Adriana, Porojan, Mihai D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305474/
https://www.ncbi.nlm.nih.gov/pubmed/34202323
http://dx.doi.org/10.3390/medicina57070653
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author Para, Ioana
Albu, Adriana
Porojan, Mihai D.
author_facet Para, Ioana
Albu, Adriana
Porojan, Mihai D.
author_sort Para, Ioana
collection PubMed
description Adipokines are active molecules with pleiotropic effects produced by adipose tissue and involved in obesity-related metabolic and cardiovascular diseases. Arterial stiffness, which is a consequence of arteriosclerosis, has been shown to be an independent predictor of cardiovascular morbidity and mortality. The pathogenesis of arterial stiffness is complex but incompletely understood. Adipokines dysregulation may induce, by various mechanisms, vascular inflammation, endothelial dysfunction, and vascular remodeling, leading to increased arterial stiffness. This article summarizes literature data regarding adipokine-related pathogenetic mechanisms involved in the development of arterial stiffness, particularly in obesity, as well as the results of clinical and epidemiological studies which investigated the relationship between adipokines and arterial stiffness.
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spelling pubmed-83054742021-07-25 Adipokines and Arterial Stiffness in Obesity Para, Ioana Albu, Adriana Porojan, Mihai D. Medicina (Kaunas) Review Adipokines are active molecules with pleiotropic effects produced by adipose tissue and involved in obesity-related metabolic and cardiovascular diseases. Arterial stiffness, which is a consequence of arteriosclerosis, has been shown to be an independent predictor of cardiovascular morbidity and mortality. The pathogenesis of arterial stiffness is complex but incompletely understood. Adipokines dysregulation may induce, by various mechanisms, vascular inflammation, endothelial dysfunction, and vascular remodeling, leading to increased arterial stiffness. This article summarizes literature data regarding adipokine-related pathogenetic mechanisms involved in the development of arterial stiffness, particularly in obesity, as well as the results of clinical and epidemiological studies which investigated the relationship between adipokines and arterial stiffness. MDPI 2021-06-25 /pmc/articles/PMC8305474/ /pubmed/34202323 http://dx.doi.org/10.3390/medicina57070653 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Para, Ioana
Albu, Adriana
Porojan, Mihai D.
Adipokines and Arterial Stiffness in Obesity
title Adipokines and Arterial Stiffness in Obesity
title_full Adipokines and Arterial Stiffness in Obesity
title_fullStr Adipokines and Arterial Stiffness in Obesity
title_full_unstemmed Adipokines and Arterial Stiffness in Obesity
title_short Adipokines and Arterial Stiffness in Obesity
title_sort adipokines and arterial stiffness in obesity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305474/
https://www.ncbi.nlm.nih.gov/pubmed/34202323
http://dx.doi.org/10.3390/medicina57070653
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