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sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy

Background: Preeclampsia occurs more often in dichorionic than in monochorionic twin pregnancy. We hypothesize that serum concentrations of biomarkers: placental growth factor (PlGF), serum soluble fms-like tyrosine kinase-1 (sFlt-1), and endoglin (Eng) differ between monochorionic and dichorionic t...

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Autores principales: Kozłowski, Szymon, Stelmaszczyk-Emmel, Anna, Szymusik, Iwona, Saletra-Bielińska, Aleksandra, Brawura-Biskupski-Samaha, Robert, Pietruski, Paweł, Osińska, Agnieszka, Kosińska-Kaczyńska, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305523/
https://www.ncbi.nlm.nih.gov/pubmed/34209832
http://dx.doi.org/10.3390/diagnostics11071181
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author Kozłowski, Szymon
Stelmaszczyk-Emmel, Anna
Szymusik, Iwona
Saletra-Bielińska, Aleksandra
Brawura-Biskupski-Samaha, Robert
Pietruski, Paweł
Osińska, Agnieszka
Kosińska-Kaczyńska, Katarzyna
author_facet Kozłowski, Szymon
Stelmaszczyk-Emmel, Anna
Szymusik, Iwona
Saletra-Bielińska, Aleksandra
Brawura-Biskupski-Samaha, Robert
Pietruski, Paweł
Osińska, Agnieszka
Kosińska-Kaczyńska, Katarzyna
author_sort Kozłowski, Szymon
collection PubMed
description Background: Preeclampsia occurs more often in dichorionic than in monochorionic twin pregnancy. We hypothesize that serum concentrations of biomarkers: placental growth factor (PlGF), serum soluble fms-like tyrosine kinase-1 (sFlt-1), and endoglin (Eng) differ between monochorionic and dichorionic twin pregnancies. Methods: A prospective observational study including 43 monochorionic and 36 dichorionic twin gestation was conducted. Blood samples were collected twice from all participants: between 11 + 0 and 13 + 6 and between 32 + 0 and 34 + 0 weeks of gestation. PlGF, sFlt-1 and Eng were measured using immnunoenzymatic assays. Results: We found a significantly higher concentration of sFlt-1 in dichorionic in comparison to monochorionic pregnancies in both the first and third trimesters. PlGF and sEng levels did not differ between mono- and dichorionic gestation in both study periods. sFlt-1 level was related to twin gestation chorionicity, while PlGF expression was not. PlGF, sFlt-1 and sEng concentrations increased significantly during gestation and were much higher in the third trimester compared to the values measured in the first trimester. Conclusions: Angiogenic biomarkers expression differ between dichorionic and monochorionic twin pregnancy. The sFlt-1 level is related to chorionicity of a twin gestation.
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spelling pubmed-83055232021-07-25 sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy Kozłowski, Szymon Stelmaszczyk-Emmel, Anna Szymusik, Iwona Saletra-Bielińska, Aleksandra Brawura-Biskupski-Samaha, Robert Pietruski, Paweł Osińska, Agnieszka Kosińska-Kaczyńska, Katarzyna Diagnostics (Basel) Article Background: Preeclampsia occurs more often in dichorionic than in monochorionic twin pregnancy. We hypothesize that serum concentrations of biomarkers: placental growth factor (PlGF), serum soluble fms-like tyrosine kinase-1 (sFlt-1), and endoglin (Eng) differ between monochorionic and dichorionic twin pregnancies. Methods: A prospective observational study including 43 monochorionic and 36 dichorionic twin gestation was conducted. Blood samples were collected twice from all participants: between 11 + 0 and 13 + 6 and between 32 + 0 and 34 + 0 weeks of gestation. PlGF, sFlt-1 and Eng were measured using immnunoenzymatic assays. Results: We found a significantly higher concentration of sFlt-1 in dichorionic in comparison to monochorionic pregnancies in both the first and third trimesters. PlGF and sEng levels did not differ between mono- and dichorionic gestation in both study periods. sFlt-1 level was related to twin gestation chorionicity, while PlGF expression was not. PlGF, sFlt-1 and sEng concentrations increased significantly during gestation and were much higher in the third trimester compared to the values measured in the first trimester. Conclusions: Angiogenic biomarkers expression differ between dichorionic and monochorionic twin pregnancy. The sFlt-1 level is related to chorionicity of a twin gestation. MDPI 2021-06-29 /pmc/articles/PMC8305523/ /pubmed/34209832 http://dx.doi.org/10.3390/diagnostics11071181 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kozłowski, Szymon
Stelmaszczyk-Emmel, Anna
Szymusik, Iwona
Saletra-Bielińska, Aleksandra
Brawura-Biskupski-Samaha, Robert
Pietruski, Paweł
Osińska, Agnieszka
Kosińska-Kaczyńska, Katarzyna
sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy
title sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy
title_full sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy
title_fullStr sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy
title_full_unstemmed sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy
title_short sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy
title_sort sflt-1, not plgf, is related to twin gestation choronicity in the first and third trimesters of pregnancy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305523/
https://www.ncbi.nlm.nih.gov/pubmed/34209832
http://dx.doi.org/10.3390/diagnostics11071181
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