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Early Intervention of Pulmonary Rehabilitation for Fibrotic Interstitial Lung Disease Is a Favorable Factor for Short-Term Improvement in Health-Related Quality of Life

Patients with fibrosing interstitial lung disease (FILD) have poor health-related quality of life (HRQOL). We analyzed predictors of short-term improvement of HRQOL after starting pulmonary rehabilitation (PR) in moderate to severe FILD patients. This study involved 28 consecutive patients with FILD...

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Autores principales: Matsuo, Satoshi, Okamoto, Masaki, Ikeuchi, Tomoyuki, Zaizen, Yoshiaki, Inomoto, Atsushi, Haraguchi, Remi, Mori, Shunichiro, Sasaki, Retsu, Nouno, Takashi, Tanaka, Tomohiro, Hoshino, Tomoaki, Tsuda, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305639/
https://www.ncbi.nlm.nih.gov/pubmed/34300319
http://dx.doi.org/10.3390/jcm10143153
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author Matsuo, Satoshi
Okamoto, Masaki
Ikeuchi, Tomoyuki
Zaizen, Yoshiaki
Inomoto, Atsushi
Haraguchi, Remi
Mori, Shunichiro
Sasaki, Retsu
Nouno, Takashi
Tanaka, Tomohiro
Hoshino, Tomoaki
Tsuda, Toru
author_facet Matsuo, Satoshi
Okamoto, Masaki
Ikeuchi, Tomoyuki
Zaizen, Yoshiaki
Inomoto, Atsushi
Haraguchi, Remi
Mori, Shunichiro
Sasaki, Retsu
Nouno, Takashi
Tanaka, Tomohiro
Hoshino, Tomoaki
Tsuda, Toru
author_sort Matsuo, Satoshi
collection PubMed
description Patients with fibrosing interstitial lung disease (FILD) have poor health-related quality of life (HRQOL). We analyzed predictors of short-term improvement of HRQOL after starting pulmonary rehabilitation (PR) in moderate to severe FILD patients. This study involved 28 consecutive patients with FILD (20 males, median age of 77.5 years), who participated in PR program of our hospital for >6 weeks. The St. George’s Respiratory Questionnaire (SGRQ) score and the 6-min walk distance (6MWD) were evaluated before and after PR, and the predictors of efficacy of PR were analyzed. The duration from diagnosis of FILD to start of PR showed a positive correlation with the increase in the SGRQ score, and the baseline SGRQ score showed a negative correlation with increase in the 6MWD. The FILD subtype, modified Medical Research Council score, and treatment history were not associated with the endpoints. According to the receiver operating characteristic curve (ROC) analyses, starting PR within 514 days after diagnosis of FILD was a significant favorable predictor of improvement in the SGRQ total score more than a minimal clinically important difference of 4. In this study, early intervention of PR and lower SGRQ score were associated with the favorable response to PR. PR for FILD should be initiated early before the disease becomes severe.
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spelling pubmed-83056392021-07-25 Early Intervention of Pulmonary Rehabilitation for Fibrotic Interstitial Lung Disease Is a Favorable Factor for Short-Term Improvement in Health-Related Quality of Life Matsuo, Satoshi Okamoto, Masaki Ikeuchi, Tomoyuki Zaizen, Yoshiaki Inomoto, Atsushi Haraguchi, Remi Mori, Shunichiro Sasaki, Retsu Nouno, Takashi Tanaka, Tomohiro Hoshino, Tomoaki Tsuda, Toru J Clin Med Article Patients with fibrosing interstitial lung disease (FILD) have poor health-related quality of life (HRQOL). We analyzed predictors of short-term improvement of HRQOL after starting pulmonary rehabilitation (PR) in moderate to severe FILD patients. This study involved 28 consecutive patients with FILD (20 males, median age of 77.5 years), who participated in PR program of our hospital for >6 weeks. The St. George’s Respiratory Questionnaire (SGRQ) score and the 6-min walk distance (6MWD) were evaluated before and after PR, and the predictors of efficacy of PR were analyzed. The duration from diagnosis of FILD to start of PR showed a positive correlation with the increase in the SGRQ score, and the baseline SGRQ score showed a negative correlation with increase in the 6MWD. The FILD subtype, modified Medical Research Council score, and treatment history were not associated with the endpoints. According to the receiver operating characteristic curve (ROC) analyses, starting PR within 514 days after diagnosis of FILD was a significant favorable predictor of improvement in the SGRQ total score more than a minimal clinically important difference of 4. In this study, early intervention of PR and lower SGRQ score were associated with the favorable response to PR. PR for FILD should be initiated early before the disease becomes severe. MDPI 2021-07-16 /pmc/articles/PMC8305639/ /pubmed/34300319 http://dx.doi.org/10.3390/jcm10143153 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Matsuo, Satoshi
Okamoto, Masaki
Ikeuchi, Tomoyuki
Zaizen, Yoshiaki
Inomoto, Atsushi
Haraguchi, Remi
Mori, Shunichiro
Sasaki, Retsu
Nouno, Takashi
Tanaka, Tomohiro
Hoshino, Tomoaki
Tsuda, Toru
Early Intervention of Pulmonary Rehabilitation for Fibrotic Interstitial Lung Disease Is a Favorable Factor for Short-Term Improvement in Health-Related Quality of Life
title Early Intervention of Pulmonary Rehabilitation for Fibrotic Interstitial Lung Disease Is a Favorable Factor for Short-Term Improvement in Health-Related Quality of Life
title_full Early Intervention of Pulmonary Rehabilitation for Fibrotic Interstitial Lung Disease Is a Favorable Factor for Short-Term Improvement in Health-Related Quality of Life
title_fullStr Early Intervention of Pulmonary Rehabilitation for Fibrotic Interstitial Lung Disease Is a Favorable Factor for Short-Term Improvement in Health-Related Quality of Life
title_full_unstemmed Early Intervention of Pulmonary Rehabilitation for Fibrotic Interstitial Lung Disease Is a Favorable Factor for Short-Term Improvement in Health-Related Quality of Life
title_short Early Intervention of Pulmonary Rehabilitation for Fibrotic Interstitial Lung Disease Is a Favorable Factor for Short-Term Improvement in Health-Related Quality of Life
title_sort early intervention of pulmonary rehabilitation for fibrotic interstitial lung disease is a favorable factor for short-term improvement in health-related quality of life
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305639/
https://www.ncbi.nlm.nih.gov/pubmed/34300319
http://dx.doi.org/10.3390/jcm10143153
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