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Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity
In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a chronic disease correlated with systemic inflammation, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity relate...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305706/ https://www.ncbi.nlm.nih.gov/pubmed/34199040 http://dx.doi.org/10.3390/children8070554 |
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author | Croce, Stefania Avanzini, Maria Antonietta Regalbuto, Corrado Cordaro, Erika Vinci, Federica Zuccotti, Gianvincenzo Calcaterra, Valeria |
author_facet | Croce, Stefania Avanzini, Maria Antonietta Regalbuto, Corrado Cordaro, Erika Vinci, Federica Zuccotti, Gianvincenzo Calcaterra, Valeria |
author_sort | Croce, Stefania |
collection | PubMed |
description | In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a chronic disease correlated with systemic inflammation, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity related diseases and metabolic disorders, including impaired glucose metabolism. In particular, Treg and Th17 cells are dynamically balanced under healthy conditions, but imbalance occurs in inflammatory and pathological states, such as obesity. Some studies demonstrated that peripheral Treg and Th17 cells exhibit increased imbalance with worsening of glucose metabolic dysfunction, already in children with obesity. In this review, we considered the role of adipose tissue immunomodulation and the potential role played by Treg/T17 imbalance on the impaired glucose metabolism in pediatric obesity. In the patient care, immune monitoring could play an important role to define preventive strategies of pediatric metabolic disease treatments. |
format | Online Article Text |
id | pubmed-8305706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83057062021-07-25 Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity Croce, Stefania Avanzini, Maria Antonietta Regalbuto, Corrado Cordaro, Erika Vinci, Federica Zuccotti, Gianvincenzo Calcaterra, Valeria Children (Basel) Review In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a chronic disease correlated with systemic inflammation, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity related diseases and metabolic disorders, including impaired glucose metabolism. In particular, Treg and Th17 cells are dynamically balanced under healthy conditions, but imbalance occurs in inflammatory and pathological states, such as obesity. Some studies demonstrated that peripheral Treg and Th17 cells exhibit increased imbalance with worsening of glucose metabolic dysfunction, already in children with obesity. In this review, we considered the role of adipose tissue immunomodulation and the potential role played by Treg/T17 imbalance on the impaired glucose metabolism in pediatric obesity. In the patient care, immune monitoring could play an important role to define preventive strategies of pediatric metabolic disease treatments. MDPI 2021-06-27 /pmc/articles/PMC8305706/ /pubmed/34199040 http://dx.doi.org/10.3390/children8070554 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Croce, Stefania Avanzini, Maria Antonietta Regalbuto, Corrado Cordaro, Erika Vinci, Federica Zuccotti, Gianvincenzo Calcaterra, Valeria Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity |
title | Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity |
title_full | Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity |
title_fullStr | Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity |
title_full_unstemmed | Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity |
title_short | Adipose Tissue Immunomodulation and Treg/Th17 Imbalance in the Impaired Glucose Metabolism of Children with Obesity |
title_sort | adipose tissue immunomodulation and treg/th17 imbalance in the impaired glucose metabolism of children with obesity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305706/ https://www.ncbi.nlm.nih.gov/pubmed/34199040 http://dx.doi.org/10.3390/children8070554 |
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