D-Propranolol Impairs EGFR Trafficking and Destabilizes Mutant p53 Counteracting AKT Signaling and Tumor Malignancy

SIMPLE SUMMARY: Cancer progression is frequently driven by altered functions of EGFR belonging to the tyrosine-kinase family of growth factor receptors and by the transcription factor p53, which is called the “genome guardian”. We report that D-Propranolol, previously used for other purposes in huma...

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Detalles Bibliográficos
Autores principales: Barra, Jonathan, Cerda-Infante, Javier, Sandoval, Lisette, Gajardo-Meneses, Patricia, Henriquez, Jenny F., Labarca, Mariana, Metz, Claudia, Venegas, Jaime, Retamal, Claudio, Oyanadel, Claudia, Cancino, Jorge, Soza, Andrea, Cuello, Mauricio A., Roa, Juan Carlos, Montecinos, Viviana P., Gonzalez, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305715/
https://www.ncbi.nlm.nih.gov/pubmed/34298835
http://dx.doi.org/10.3390/cancers13143622

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