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Small Leucine-Rich Proteoglycans (SLRPs) in the Retina

Retinal diseases such as age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy (DR) are the leading causes of visual impairment worldwide. There is a critical need to understand the structural and cellular components that play a vital role in the pathophy...

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Autores principales: Low, Shermaine W. Y., Connor, Thomas B., Kassem, Iris S., Costakos, Deborah M., Chaurasia, Shyam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305803/
https://www.ncbi.nlm.nih.gov/pubmed/34298915
http://dx.doi.org/10.3390/ijms22147293
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author Low, Shermaine W. Y.
Connor, Thomas B.
Kassem, Iris S.
Costakos, Deborah M.
Chaurasia, Shyam S.
author_facet Low, Shermaine W. Y.
Connor, Thomas B.
Kassem, Iris S.
Costakos, Deborah M.
Chaurasia, Shyam S.
author_sort Low, Shermaine W. Y.
collection PubMed
description Retinal diseases such as age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy (DR) are the leading causes of visual impairment worldwide. There is a critical need to understand the structural and cellular components that play a vital role in the pathophysiology of retinal diseases. One potential component is the family of structural proteins called small leucine-rich proteoglycans (SLRPs). SLRPs are crucial in many fundamental biological processes involved in the maintenance of retinal homeostasis. They are present within the extracellular matrix (ECM) of connective and vascular tissues and contribute to tissue organization and modulation of cell growth. They play a vital role in cell–matrix interactions in many upstream signaling pathways involved in fibrillogenesis and angiogenesis. In this comprehensive review, we describe the expression patterns and function of SLRPs in the retina, including Biglycan and Decorin from class I; Fibromodulin, Lumican, and a Proline/arginine-rich end leucine-rich repeat protein (PRELP) from class II; Opticin and Osteoglycin/Mimecan from class III; and Chondroadherin (CHAD), Tsukushi and Nyctalopin from class IV.
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spelling pubmed-83058032021-07-25 Small Leucine-Rich Proteoglycans (SLRPs) in the Retina Low, Shermaine W. Y. Connor, Thomas B. Kassem, Iris S. Costakos, Deborah M. Chaurasia, Shyam S. Int J Mol Sci Review Retinal diseases such as age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy (DR) are the leading causes of visual impairment worldwide. There is a critical need to understand the structural and cellular components that play a vital role in the pathophysiology of retinal diseases. One potential component is the family of structural proteins called small leucine-rich proteoglycans (SLRPs). SLRPs are crucial in many fundamental biological processes involved in the maintenance of retinal homeostasis. They are present within the extracellular matrix (ECM) of connective and vascular tissues and contribute to tissue organization and modulation of cell growth. They play a vital role in cell–matrix interactions in many upstream signaling pathways involved in fibrillogenesis and angiogenesis. In this comprehensive review, we describe the expression patterns and function of SLRPs in the retina, including Biglycan and Decorin from class I; Fibromodulin, Lumican, and a Proline/arginine-rich end leucine-rich repeat protein (PRELP) from class II; Opticin and Osteoglycin/Mimecan from class III; and Chondroadherin (CHAD), Tsukushi and Nyctalopin from class IV. MDPI 2021-07-07 /pmc/articles/PMC8305803/ /pubmed/34298915 http://dx.doi.org/10.3390/ijms22147293 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Low, Shermaine W. Y.
Connor, Thomas B.
Kassem, Iris S.
Costakos, Deborah M.
Chaurasia, Shyam S.
Small Leucine-Rich Proteoglycans (SLRPs) in the Retina
title Small Leucine-Rich Proteoglycans (SLRPs) in the Retina
title_full Small Leucine-Rich Proteoglycans (SLRPs) in the Retina
title_fullStr Small Leucine-Rich Proteoglycans (SLRPs) in the Retina
title_full_unstemmed Small Leucine-Rich Proteoglycans (SLRPs) in the Retina
title_short Small Leucine-Rich Proteoglycans (SLRPs) in the Retina
title_sort small leucine-rich proteoglycans (slrps) in the retina
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305803/
https://www.ncbi.nlm.nih.gov/pubmed/34298915
http://dx.doi.org/10.3390/ijms22147293
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