Cargando…
Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain
Multiple sclerosis (MS) is the most demyelinating disease of the central nervous system (CNS) characterized by neuroinflammation. Oligodendrocyte progenitor cells (OPCs) are cycling cells in the developing and adult CNS that, under demyelinating conditions, migrate to the site of lesions and differe...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305962/ https://www.ncbi.nlm.nih.gov/pubmed/34298893 http://dx.doi.org/10.3390/ijms22147277 |
_version_ | 1783727696362078208 |
---|---|
author | Cherchi, Federica Bulli, Irene Venturini, Martina Pugliese, Anna Maria Coppi, Elisabetta |
author_facet | Cherchi, Federica Bulli, Irene Venturini, Martina Pugliese, Anna Maria Coppi, Elisabetta |
author_sort | Cherchi, Federica |
collection | PubMed |
description | Multiple sclerosis (MS) is the most demyelinating disease of the central nervous system (CNS) characterized by neuroinflammation. Oligodendrocyte progenitor cells (OPCs) are cycling cells in the developing and adult CNS that, under demyelinating conditions, migrate to the site of lesions and differentiate into mature oligodendrocytes to remyelinate damaged axons. However, this process fails during disease chronicization due to impaired OPC differentiation. Moreover, OPCs are crucial players in neuro-glial communication as they receive synaptic inputs from neurons and express ion channels and neurotransmitter/neuromodulator receptors that control their maturation. Ion channels are recognized as attractive therapeutic targets, and indeed ligand-gated and voltage-gated channels can both be found among the top five pharmaceutical target groups of FDA-approved agents. Their modulation ameliorates some of the symptoms of MS and improves the outcome of related animal models. However, the exact mechanism of action of ion-channel targeting compounds is often still unclear due to the wide expression of these channels on neurons, glia, and infiltrating immune cells. The present review summarizes recent findings in the field to get further insights into physio-pathophysiological processes and possible therapeutic mechanisms of drug actions. |
format | Online Article Text |
id | pubmed-8305962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83059622021-07-25 Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain Cherchi, Federica Bulli, Irene Venturini, Martina Pugliese, Anna Maria Coppi, Elisabetta Int J Mol Sci Review Multiple sclerosis (MS) is the most demyelinating disease of the central nervous system (CNS) characterized by neuroinflammation. Oligodendrocyte progenitor cells (OPCs) are cycling cells in the developing and adult CNS that, under demyelinating conditions, migrate to the site of lesions and differentiate into mature oligodendrocytes to remyelinate damaged axons. However, this process fails during disease chronicization due to impaired OPC differentiation. Moreover, OPCs are crucial players in neuro-glial communication as they receive synaptic inputs from neurons and express ion channels and neurotransmitter/neuromodulator receptors that control their maturation. Ion channels are recognized as attractive therapeutic targets, and indeed ligand-gated and voltage-gated channels can both be found among the top five pharmaceutical target groups of FDA-approved agents. Their modulation ameliorates some of the symptoms of MS and improves the outcome of related animal models. However, the exact mechanism of action of ion-channel targeting compounds is often still unclear due to the wide expression of these channels on neurons, glia, and infiltrating immune cells. The present review summarizes recent findings in the field to get further insights into physio-pathophysiological processes and possible therapeutic mechanisms of drug actions. MDPI 2021-07-06 /pmc/articles/PMC8305962/ /pubmed/34298893 http://dx.doi.org/10.3390/ijms22147277 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cherchi, Federica Bulli, Irene Venturini, Martina Pugliese, Anna Maria Coppi, Elisabetta Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain |
title | Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain |
title_full | Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain |
title_fullStr | Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain |
title_full_unstemmed | Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain |
title_short | Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain |
title_sort | ion channels as new attractive targets to improve re-myelination processes in the brain |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305962/ https://www.ncbi.nlm.nih.gov/pubmed/34298893 http://dx.doi.org/10.3390/ijms22147277 |
work_keys_str_mv | AT cherchifederica ionchannelsasnewattractivetargetstoimproveremyelinationprocessesinthebrain AT bulliirene ionchannelsasnewattractivetargetstoimproveremyelinationprocessesinthebrain AT venturinimartina ionchannelsasnewattractivetargetstoimproveremyelinationprocessesinthebrain AT puglieseannamaria ionchannelsasnewattractivetargetstoimproveremyelinationprocessesinthebrain AT coppielisabetta ionchannelsasnewattractivetargetstoimproveremyelinationprocessesinthebrain |