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Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice?

Endorectal ultrasound applications in the evaluation of rectal tumors could be a useful tool in achieving proper staging of rectal cancer. The purpose of this study was to compare the efficacy of rectal tumor staging by flexible endoscopic ultrasound (EUS) with real-time elastography (RTE) using the...

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Autores principales: Catinean, Adrian, Balan, Gheorghe G., Mezei, Anita, Botan, Emil-Claudiu, Mitre, Andrei-Otto, Motocu, Radu, Graur, Florin, Eniu, Dan-Tudor, Neag, Maria-Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305995/
https://www.ncbi.nlm.nih.gov/pubmed/34209811
http://dx.doi.org/10.3390/diagnostics11071180
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author Catinean, Adrian
Balan, Gheorghe G.
Mezei, Anita
Botan, Emil-Claudiu
Mitre, Andrei-Otto
Motocu, Radu
Graur, Florin
Eniu, Dan-Tudor
Neag, Maria-Adriana
author_facet Catinean, Adrian
Balan, Gheorghe G.
Mezei, Anita
Botan, Emil-Claudiu
Mitre, Andrei-Otto
Motocu, Radu
Graur, Florin
Eniu, Dan-Tudor
Neag, Maria-Adriana
author_sort Catinean, Adrian
collection PubMed
description Endorectal ultrasound applications in the evaluation of rectal tumors could be a useful tool in achieving proper staging of rectal cancer. The purpose of this study was to compare the efficacy of rectal tumor staging by flexible endoscopic ultrasound (EUS) with real-time elastography (RTE) using the gold standard post-surgery histological analysis of the resected tissue as the control. The second aim of our research was to establish cutoff values for the EUS-RTE strain ratio corresponding to stages by independently comparing the stiffness values obtained with histology and EUS-RTE staging in order to minimize observation bias. We evaluated the records of 130 patients with a rectal tumor confirmed by biopsy. EUS was used in 70 patients, EUS-RTE—in the other 60. We found no statistically significant differences in staging accuracy when comparing EUS to EUS-RTE. Through a correspondence method between staging assessment and the EUS-RTE stain ratio, we identified cutoff intervals for T2, T3, and T4 staging that were nonoverlapping and proved to be statistically significant in terms of EUS-RTE values (significantly different ascending values from one interval to the other). We found that EUS-RTE offers slightly better, although not statistically significant sensitivity and specificity for T and N stage predictions compared to 2D EUS. Our results showed that EUS-RTE offers slightly higher sensitivity and specificity compared to EUS. Reliable cutoff intervals were found for strain rate elastography, previously available only for shear wave elastography (SWE) which is currently unavailable on any EUS system. Thus, these commonly available EUS-RTE systems can serve as a complementary tool in the staging of rectal tumors.
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spelling pubmed-83059952021-07-25 Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice? Catinean, Adrian Balan, Gheorghe G. Mezei, Anita Botan, Emil-Claudiu Mitre, Andrei-Otto Motocu, Radu Graur, Florin Eniu, Dan-Tudor Neag, Maria-Adriana Diagnostics (Basel) Article Endorectal ultrasound applications in the evaluation of rectal tumors could be a useful tool in achieving proper staging of rectal cancer. The purpose of this study was to compare the efficacy of rectal tumor staging by flexible endoscopic ultrasound (EUS) with real-time elastography (RTE) using the gold standard post-surgery histological analysis of the resected tissue as the control. The second aim of our research was to establish cutoff values for the EUS-RTE strain ratio corresponding to stages by independently comparing the stiffness values obtained with histology and EUS-RTE staging in order to minimize observation bias. We evaluated the records of 130 patients with a rectal tumor confirmed by biopsy. EUS was used in 70 patients, EUS-RTE—in the other 60. We found no statistically significant differences in staging accuracy when comparing EUS to EUS-RTE. Through a correspondence method between staging assessment and the EUS-RTE stain ratio, we identified cutoff intervals for T2, T3, and T4 staging that were nonoverlapping and proved to be statistically significant in terms of EUS-RTE values (significantly different ascending values from one interval to the other). We found that EUS-RTE offers slightly better, although not statistically significant sensitivity and specificity for T and N stage predictions compared to 2D EUS. Our results showed that EUS-RTE offers slightly higher sensitivity and specificity compared to EUS. Reliable cutoff intervals were found for strain rate elastography, previously available only for shear wave elastography (SWE) which is currently unavailable on any EUS system. Thus, these commonly available EUS-RTE systems can serve as a complementary tool in the staging of rectal tumors. MDPI 2021-06-29 /pmc/articles/PMC8305995/ /pubmed/34209811 http://dx.doi.org/10.3390/diagnostics11071180 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Catinean, Adrian
Balan, Gheorghe G.
Mezei, Anita
Botan, Emil-Claudiu
Mitre, Andrei-Otto
Motocu, Radu
Graur, Florin
Eniu, Dan-Tudor
Neag, Maria-Adriana
Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice?
title Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice?
title_full Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice?
title_fullStr Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice?
title_full_unstemmed Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice?
title_short Endoscopic Ultrasound Elastography in the Assessment of Rectal Tumors: How Well Does It Work in Clinical Practice?
title_sort endoscopic ultrasound elastography in the assessment of rectal tumors: how well does it work in clinical practice?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305995/
https://www.ncbi.nlm.nih.gov/pubmed/34209811
http://dx.doi.org/10.3390/diagnostics11071180
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