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Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review

Magnetic nanoparticles have attracted significant attention in various disciplines, including engineering and medicine. Microfluidic chips and lab-on-a-chip devices, with precise control over small volumes of fluids and tiny particles, are appropriate tools for the synthesis, manipulation, and evalu...

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Autores principales: Abedini-Nassab, Roozbeh, Pouryosef Miandoab, Mahrad, Şaşmaz, Merivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306075/
https://www.ncbi.nlm.nih.gov/pubmed/34210058
http://dx.doi.org/10.3390/mi12070768
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author Abedini-Nassab, Roozbeh
Pouryosef Miandoab, Mahrad
Şaşmaz, Merivan
author_facet Abedini-Nassab, Roozbeh
Pouryosef Miandoab, Mahrad
Şaşmaz, Merivan
author_sort Abedini-Nassab, Roozbeh
collection PubMed
description Magnetic nanoparticles have attracted significant attention in various disciplines, including engineering and medicine. Microfluidic chips and lab-on-a-chip devices, with precise control over small volumes of fluids and tiny particles, are appropriate tools for the synthesis, manipulation, and evaluation of nanoparticles. Moreover, the controllability and automation offered by the microfluidic chips in combination with the unique capabilities of the magnetic nanoparticles and their ability to be remotely controlled and detected, have recently provided tremendous advances in biotechnology. In particular, microfluidic chips with magnetic nanoparticles serve as sensitive, high throughput, and portable devices for contactless detecting and manipulating DNAs, RNAs, living cells, and viruses. In this work, we review recent fundamental advances in the field with a focus on biomedical applications. First, we study novel microfluidic-based methods in synthesizing magnetic nanoparticles as well as microparticles encapsulating them. We review both continues-flow and droplet-based microreactors, including the ones based on the cross-flow, co-flow, and flow-focusing methods. Then, we investigate the microfluidic-based methods for manipulating tiny magnetic particles. These manipulation techniques include the ones based on external magnets, embedded micro-coils, and magnetic thin films. Finally, we review techniques invented for the detection and magnetic measurement of magnetic nanoparticles and magnetically labeled bioparticles. We include the advances in anisotropic magnetoresistive, giant magnetoresistive, tunneling magnetoresistive, and magnetorelaxometry sensors. Overall, this review covers a wide range of the field uniquely and provides essential information for designing “lab-on-a-chip” systems for synthesizing magnetic nanoparticles, labeling bioparticles with them, and sorting and detecting them on a single chip.
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spelling pubmed-83060752021-07-25 Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review Abedini-Nassab, Roozbeh Pouryosef Miandoab, Mahrad Şaşmaz, Merivan Micromachines (Basel) Review Magnetic nanoparticles have attracted significant attention in various disciplines, including engineering and medicine. Microfluidic chips and lab-on-a-chip devices, with precise control over small volumes of fluids and tiny particles, are appropriate tools for the synthesis, manipulation, and evaluation of nanoparticles. Moreover, the controllability and automation offered by the microfluidic chips in combination with the unique capabilities of the magnetic nanoparticles and their ability to be remotely controlled and detected, have recently provided tremendous advances in biotechnology. In particular, microfluidic chips with magnetic nanoparticles serve as sensitive, high throughput, and portable devices for contactless detecting and manipulating DNAs, RNAs, living cells, and viruses. In this work, we review recent fundamental advances in the field with a focus on biomedical applications. First, we study novel microfluidic-based methods in synthesizing magnetic nanoparticles as well as microparticles encapsulating them. We review both continues-flow and droplet-based microreactors, including the ones based on the cross-flow, co-flow, and flow-focusing methods. Then, we investigate the microfluidic-based methods for manipulating tiny magnetic particles. These manipulation techniques include the ones based on external magnets, embedded micro-coils, and magnetic thin films. Finally, we review techniques invented for the detection and magnetic measurement of magnetic nanoparticles and magnetically labeled bioparticles. We include the advances in anisotropic magnetoresistive, giant magnetoresistive, tunneling magnetoresistive, and magnetorelaxometry sensors. Overall, this review covers a wide range of the field uniquely and provides essential information for designing “lab-on-a-chip” systems for synthesizing magnetic nanoparticles, labeling bioparticles with them, and sorting and detecting them on a single chip. MDPI 2021-06-29 /pmc/articles/PMC8306075/ /pubmed/34210058 http://dx.doi.org/10.3390/mi12070768 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abedini-Nassab, Roozbeh
Pouryosef Miandoab, Mahrad
Şaşmaz, Merivan
Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review
title Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review
title_full Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review
title_fullStr Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review
title_full_unstemmed Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review
title_short Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review
title_sort microfluidic synthesis, control, and sensing of magnetic nanoparticles: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306075/
https://www.ncbi.nlm.nih.gov/pubmed/34210058
http://dx.doi.org/10.3390/mi12070768
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