Cargando…

Somatotroph Tumors and the Epigenetic Status of the GNAS Locus

Forty percent of somatotroph tumors harbor recurrent activating GNAS mutations, historically called the gsp oncogene. In gsp-negative somatotroph tumors, GNAS expression itself is highly variable; those with GNAS overexpression most resemble phenotypically those carrying the gsp oncogene. GNAS is mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Romanet, Pauline, Galluso, Justine, Kamenicky, Peter, Hage, Mirella, Theodoropoulou, Marily, Roche, Catherine, Graillon, Thomas, Etchevers, Heather C., De Murat, Daniel, Mougel, Grégory, Figarella-Branger, Dominique, Dufour, Henry, Cuny, Thomas, Assié, Guillaume, Barlier, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306130/ https://www.ncbi.nlm.nih.gov/pubmed/34299200 http://dx.doi.org/10.3390/ijms22147570

Ejemplares similares

In vitro impact of pegvisomant on growth hormone-secreting pituitary adenoma cells
por: Cuny, Thomas, et al.
Publicado: (2016)

Brief CommunicationCirculating tumor DNA is present in the most aggressive meningiomas
por: Graillon, Thomas, et al.
Publicado: (2020)

Dose-Dependent Dual Role of PIT-1 (POU1F1) in Somatolactotroph Cell Proliferation and Apoptosis
por: Jullien, Nicolas, et al.
Publicado: (2015)

Pasireotide is more effective than octreotide, alone or combined with everolimus on human meningioma in vitro
por: Graillon, Thomas, et al.
Publicado: (2017)

Co-Targeting MAP Kinase and Pi3K-Akt-mTOR Pathways in Meningioma: Preclinical Study of Alpelisib and Trametinib
por: Mondielli, Gregoire, et al.
Publicado: (2022)

Karyotyping and analysis of GNAS locus in intramuscular myxomas
por: Panagopoulos, Ioannis, et al.
Publicado: (2017)

Functioning Mediastinal Paraganglioma Associated with a Germline Mutation of von Hippel-Lindau Gene
por: Bahougne, Thibault, et al.
Publicado: (2018)

GNAS locus: bone related diseases and mouse models
por: Yang, Wan, et al.
Publicado: (2023)

Pseudohypoparathyroidism Type Ib Associated with Novel Duplications in the GNAS Locus
por: Perez-Nanclares, Gustavo, et al.
Publicado: (2015)

Systematic detection of mosaicism by using digital NGS reveals three new MEN1 mosaicisms
por: Lagarde, Arnaud, et al.
Publicado: (2022)

Preoperative Medical Treatment for Patients With Acromegaly: Yes or No?
por: Albarel, Frederique, et al.
Publicado: (2022)

Clinically silent somatotroph adenomas are common
por: Wade, Alisha N, et al.
Publicado: (2011)

Glucocorticoid Receptors Are Making a Comeback in Corticotroph Tumorigenesis
por: Theodoropoulou, Marily
Publicado: (2021)

A novel variant in the GNAS complex locus causes Albright hereditary osteodystrophy with pseudopseudohypoparathyroidism
por: Smith, Jeffrey S., et al.
Publicado: (2022)

Editorial: New insights into multiple endocrine neoplasia type 1
por: Barlier, Anne, et al.
Publicado: (2023)

Change in the immunophenotype of a somatotroph adenoma resulting in gigantism
por: Thawani, Jayesh P., et al.
Publicado: (2014)

Thyrotropinoma with silent somatotroph and lactotroph adenoma during pregnancy
por: Wu, Yu-Fang, et al.
Publicado: (2022)

Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts
por: Faias, Sandra, et al.
Publicado: (2020)

Genomics in Cushing’s Disease: The Dawn of a New Era
por: Reincke, Martin, et al.
Publicado: (2021)

Genetics of Cushing’s disease: from the lab to clinical practice
por: Theodoropoulou, Marily, et al.
Publicado: (2022)

Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription
por: Lucia, Kristin, et al.
Publicado: (2020)

The GNAS Locus: Quintessential Complex Gene Encoding Gsα, XLαs, and other Imprinted Transcripts
por: Bastepe, Murat
Publicado: (2007)

An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer
por: Garcia-Murillas, Isaac, et al.
Publicado: (2013)

Methylation and Transcripts Expression at the Imprinted GNAS Locus in Human Embryonic and Induced Pluripotent Stem Cells and Their Derivatives
por: Grybek, Virginie, et al.
Publicado: (2014)

Genetic and epigenetic alterations in the GNAS locus and clinical consequences in Pseudohypoparathyroidism: Italian common healthcare pathways adoption
por: de Sanctis, L., et al.
Publicado: (2016)

Treating age-related changes in somatotrophic hormones, sleep, and cognition
por: Vitiello, Michael V., et al.
Publicado: (2001)

Tumour-infiltrating cytotoxic T lymphocytes in somatotroph pituitary neuroendocrine tumours
por: Iacovazzo, Donato, et al.
Publicado: (2019)

Pituitary Somatotroph Adenoma-derived Exosomes: Characterization of Nonhormonal Actions
por: Zhou, Cuiqi, et al.
Publicado: (2021)

Identification of a Novel Imprinted Transcript in the Porcine GNAS Complex Locus Using Methylome and Transcriptome of Parthenogenetic Fetuses
por: Ahn, Jinsoo, et al.
Publicado: (2020)

Lentiviral and Moloney Retroviral Expression of Green Fluorescent Protein in Somatotrophs In Vivo
por: Okada, Masayoshi, et al.
Publicado: (2013)

Silencing of RASSF3 by DNA Hypermethylation Is Associated with Tumorigenesis in Somatotroph Adenomas
por: Peng, Hu, et al.
Publicado: (2013)

Case Report: Cytologic Description of Somatotroph Pituitary Adenoma in a Cat
por: Alonso, Flavio H., et al.
Publicado: (2022)

Early Onset GH Excess: Somatotroph Adenoma in a Young Adult
por: Galbiati, Francesca, et al.
Publicado: (2023)

Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway
por: Tabouret, Emeline, et al.
Publicado: (2015)

The Integrated Stress Response Is Tumorigenic and Constitutes a Therapeutic Liability in Somatotroph Adenomas
por: Li, Zhenye, et al.
Publicado: (2022)

Gene Dosage Effects at the Imprinted Gnas Cluster
por: Ball, Simon T., et al.
Publicado: (2013)

Immunohistochemical localization and morphometry of somatotrophs and lactotrophs in protein, probiotic and symbiotic supplemented molted layers
por: Anwar, H., et al.
Publicado: (2012)

Somatotroph-Specific Aip-Deficient Mice Display Pretumorigenic Alterations in Cell-Cycle Signaling
por: Gillam, Mary P., et al.
Publicado: (2017)

Corticosterone induces growth hormone expression in pituitary somatotrophs during goose embryonic development
por: YU, Jianning, et al.
Publicado: (2018)

Identification of Serum miRNA-423-5p Expression Signature in Somatotroph Adenomas
por: Zhao, Sida, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jh44h9hp1qvn0dbujpv8mlgf27