Cargando…

In Vitro and In Vivo Pharmaco-Toxicological Characterization of 1-Cyclohexyl-x-methoxybenzene Derivatives in Mice: Comparison with Tramadol and PCP

1-cyclohexyl-x-methoxybenzene is a novel psychoactive substance (NPS), first discovered in Europe in 2012 as unknown racemic mixture of its three stereoisomers: ortho, meta and para. Each of these has structural similarities with the analgesic tramadol and the dissociative anesthetic phencyclidine....

Descripción completa

Detalles Bibliográficos
Autores principales:	Bilel, Sabrine, Tirri, Micaela, Arfè, Raffaella, Sturaro, Chiara, Fantinati, Anna, Cristofori, Virginia, Bernardi, Tatiana, Boccuto, Federica, Cavallo, Marco, Cavalli, Alessandro, De-Giorgio, Fabio, Calò, Girolamo, Marti, Matteo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306156/ https://www.ncbi.nlm.nih.gov/pubmed/34299276 http://dx.doi.org/10.3390/ijms22147659

Ejemplares similares

Pharmaco-Toxicological Effects of Atypical Synthetic Cathinone Mephtetramine (MTTA) in Mice: Possible Reasons for Its Brief Appearance over NPSs Scene
por: Corli, Giorgia, et al.
Publicado: (2023)

Behavioral and Pharmacokinetics Studies of N-Methyl-2-Aminoindane (NM2AI) in Mice: An Aminoindane Briefly Used in the Illicit Drug Market
por: Tirri, Micaela, et al.
Publicado: (2023)

Effect of -NBOMe Compounds on Sensorimotor, Motor, and Prepulse Inhibition Responses in Mice in Comparison With the 2C Analogs and Lysergic Acid Diethylamide: From Preclinical Evidence to Forensic Implication in Driving Under the Influence of Drugs
por: Tirri, Micaela, et al.
Publicado: (2022)

Acute DOB and PMA Administration Impairs Motor and Sensorimotor Responses in Mice and Causes Hallucinogenic Effects in Adult Zebrafish
por: Tirri, Micaela, et al.
Publicado: (2020)

Synthetic cannabinoid JWH-073 alters both acute behavior and in vivo/vitro electrophysiological responses in mice
por: Barbieri, Mario, et al.
Publicado: (2022)

Sensorimotor Alterations Induced by Novel Fentanyl Analogs in Mice: Possible Impact on Human Driving Performances
por: Bilel, Sabrine, et al.
Publicado: (2023)

Pharmacological and Behavioral Effects of the Synthetic Cannabinoid AKB48 in Rats
por: Bilel, Sabrine, et al.
Publicado: (2019)

Worsening of the Toxic Effects of (±)Cis-4,4′-DMAR Following Its Co-Administration with (±)Trans-4,4′-DMAR: Neuro-Behavioural, Physiological, Immunohistochemical and Metabolic Studies in Mice
por: Tirri, Micaela, et al.
Publicado: (2021)

The Old and the New: Cardiovascular and Respiratory Alterations Induced by Acute JWH-018 Administration Compared to Δ(9)-THC—A Preclinical Study in Mice
por: Marchetti, Beatrice, et al.
Publicado: (2023)

In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice
por: Tirri, Micaela, et al.
Publicado: (2022)

Metabolism study and toxicological determination of mephtetramine in biological samples by liquid chromatography coupled with high‐resolution mass spectrometry
por: Odoardi, Sara, et al.
Publicado: (2021)

1,3,5-Trichloro-2-methoxybenzene
por: Telu, Sanjay, et al.
Publicado: (2008)

Epigenetic Studies for Evaluation of NPS Toxicity: Focus on Synthetic Cannabinoids and Cathinones
por: Mazdai, Leila, et al.
Publicado: (2022)

MAM-2201 acute administration impairs motor, sensorimotor, prepulse inhibition, and memory functions in mice: a comparison with its analogue AM-2201
por: Corli, Giorgia, et al.
Publicado: (2023)

Partial Reversible Inhibition of Enzymes and Its Metabolic and Pharmaco-Toxicological Implications
por: Masson, Patrick, et al.
Publicado: (2023)

Single Exposure to the Cathinones MDPV and α-PVP Alters Molecular Markers of Neuroplasticity in the Adult Mouse Brain
por: Caffino, Lucia, et al.
Publicado: (2021)

The Abuse Potential of Novel Synthetic Phencyclidine Derivative 1-(1-(4-Fluorophenyl)Cyclohexyl)Piperidine (4′-F-PCP) in Rodents
por: Ryu, In Soo, et al.
Publicado: (2020)

4-Benzyloxy-2-bromo-1-methoxybenzene
por: Huang, Xing, et al.
Publicado: (2011)

The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems
por: Firenzuoli, F., et al.
Publicado: (2008)

3,5-Bis(adamantan-1-yl)-1-methoxybenzene
por: Li, Peng-Fei, et al.
Publicado: (2012)

Antibiotics: Conventional Therapy and Natural Compounds with Antibacterial Activity—A Pharmaco-Toxicological Screening
por: Pancu, Daniel Florin, et al.
Publicado: (2021)

New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile
por: Vasincu, Ioana-Mirela, et al.
Publicado: (2021)

Pharmaco-Toxicological Assessment of the Combined Cytotoxic Effects of Digoxin and Betulinic Acid in Melanoma Cells
por: Rednic, Robert, et al.
Publicado: (2022)

Acute Cardiovascular and Cardiorespiratory Effects of JWH-018 in Awake and Freely Moving Mice: Mechanism of Action and Possible Antidotal Interventions?
por: Marchetti, Beatrice, et al.
Publicado: (2023)

Effect of Repeated Administration of ɣ-Valerolactone (GVL) and GHB in the Mouse: Neuroadaptive Changes of the GHB and GABAergic System
por: Frisoni, Paolo, et al.
Publicado: (2023)

A robust reprogramming strategy for generating hepatocyte-like cells usable in pharmaco-toxicological studies
por: Garcia-Llorens, Guillem, et al.
Publicado: (2023)

Toxicology of tramadol following chronic exposure based on metabolomics of the cerebrum in mice
por: Xia, Wei, et al.
Publicado: (2020)

1-[2,2-Bis(phenylsulfonyl)ethenyl]-4-methoxybenzene
por: Asahara, Haruyasu, et al.
Publicado: (2012)

1-Benzyloxy-2,5-bis(chloromethyl)-4-methoxybenzene
por: Trad, Hager, et al.
Publicado: (2012)

Structure–Activity Relationship Studies on Oxazolo[3,4-a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent In Vivo Activity
por: Albanese, Valentina, et al.
Publicado: (2021)

Pharmaco-prosthodontics revisited
por: Jagadeeshwaran, A. R., et al.
Publicado: (2012)

Oleogel Formulations for the Topical Delivery of Betulin and Lupeol in Skin Injuries—Preparation, Physicochemical Characterization, and Pharmaco-Toxicological Evaluation
por: Pârvănescu (Pană), Ramona Daniela, et al.
Publicado: (2021)

Stability Indicating HPLC Method for the Determination of Chiral Purity of R-(-)-5-[2-aminopropyl]-2-methoxybenzene Sulfonamide
por: Kasawar, G. B., et al.
Publicado: (2009)

Effect of 4-Allyl-1-hydroxy-2-methoxybenzene (Eugenol) on Inflammatory and Apoptosis Processes in Dental Pulp Fibroblasts
por: Martínez-Herrera, Andrea, et al.
Publicado: (2016)

1-(2,3-Dibenzimidazol-2-ylpropyl)-2-methoxybenzene Is a Syk Inhibitor with Anti-Inflammatory Properties
por: Kim, Eunji, et al.
Publicado: (2016)

Origins of the PCP Shortage
por: Hess, Sharon Folkenroth
Publicado: (2022)

Design, synthesis and pharmaco-toxicological assessment of 5-mercapto-1,2,4-triazole derivatives with antibacterial and antiproliferative activity
por: Mioc, Marius, et al.
Publicado: (2017)

Papain-like cysteine proteinase zone (PCP-zone) and PCP structural catalytic core (PCP-SCC) of enzymes with cysteine proteinase fold
por: Denessiouk, Konstantin, et al.
Publicado: (2020)

PHARMACO – THERAPEUTICS OF DASEMANI DRUGS
por: Sircar, N. N.
Publicado: (1984)

ArrhythmoGenoPharmacoTherapy
por: Tosaki, Arpad
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ido05pujkeplsuleaob0l5gp92