Cargando…

Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives

In the last decade, the gastrointestinal microbiota has been recognised as being essential for health. Indeed, several publications have documented the suitability of probiotics, prebiotics, and symbiotics in the management of different diseases such as diabetes mellitus (DM). Advances in laboratory...

Descripción completa

Detalles Bibliográficos
Autores principales: Cabello-Olmo, Miriam, Araña, Miriam, Urtasun, Raquel, Encio, Ignacio J., Barajas, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306164/
https://www.ncbi.nlm.nih.gov/pubmed/34359462
http://dx.doi.org/10.3390/foods10071590
_version_ 1783727744330235904
author Cabello-Olmo, Miriam
Araña, Miriam
Urtasun, Raquel
Encio, Ignacio J.
Barajas, Miguel
author_facet Cabello-Olmo, Miriam
Araña, Miriam
Urtasun, Raquel
Encio, Ignacio J.
Barajas, Miguel
author_sort Cabello-Olmo, Miriam
collection PubMed
description In the last decade, the gastrointestinal microbiota has been recognised as being essential for health. Indeed, several publications have documented the suitability of probiotics, prebiotics, and symbiotics in the management of different diseases such as diabetes mellitus (DM). Advances in laboratory techniques have allowed the identification and characterisation of new biologically active molecules, referred to as “postbiotics”. Postbiotics are defined as functional bioactive compounds obtained from food-grade microorganisms that confer health benefits when administered in adequate amounts. They include cell structures, secreted molecules or metabolic by-products, and inanimate microorganisms. This heterogeneous group of molecules presents a broad range of mechanisms and may exhibit some advantages over traditional “biotics” such as probiotics and prebiotics. Owing to the growing incidence of DM worldwide and the implications of the microbiota in the disease progression, postbiotics appear to be good candidates as novel therapeutic targets. In the present review, we summarise the current knowledge about postbiotic compounds and their potential application in diabetes management. Additionally, we envision future perspectives on this topic. In summary, the results indicate that postbiotics hold promise as a potential novel therapeutic strategy for DM.
format Online
Article
Text
id pubmed-8306164
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83061642021-07-25 Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives Cabello-Olmo, Miriam Araña, Miriam Urtasun, Raquel Encio, Ignacio J. Barajas, Miguel Foods Review In the last decade, the gastrointestinal microbiota has been recognised as being essential for health. Indeed, several publications have documented the suitability of probiotics, prebiotics, and symbiotics in the management of different diseases such as diabetes mellitus (DM). Advances in laboratory techniques have allowed the identification and characterisation of new biologically active molecules, referred to as “postbiotics”. Postbiotics are defined as functional bioactive compounds obtained from food-grade microorganisms that confer health benefits when administered in adequate amounts. They include cell structures, secreted molecules or metabolic by-products, and inanimate microorganisms. This heterogeneous group of molecules presents a broad range of mechanisms and may exhibit some advantages over traditional “biotics” such as probiotics and prebiotics. Owing to the growing incidence of DM worldwide and the implications of the microbiota in the disease progression, postbiotics appear to be good candidates as novel therapeutic targets. In the present review, we summarise the current knowledge about postbiotic compounds and their potential application in diabetes management. Additionally, we envision future perspectives on this topic. In summary, the results indicate that postbiotics hold promise as a potential novel therapeutic strategy for DM. MDPI 2021-07-08 /pmc/articles/PMC8306164/ /pubmed/34359462 http://dx.doi.org/10.3390/foods10071590 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cabello-Olmo, Miriam
Araña, Miriam
Urtasun, Raquel
Encio, Ignacio J.
Barajas, Miguel
Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives
title Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives
title_full Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives
title_fullStr Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives
title_full_unstemmed Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives
title_short Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives
title_sort role of postbiotics in diabetes mellitus: current knowledge and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306164/
https://www.ncbi.nlm.nih.gov/pubmed/34359462
http://dx.doi.org/10.3390/foods10071590
work_keys_str_mv AT cabelloolmomiriam roleofpostbioticsindiabetesmellituscurrentknowledgeandfutureperspectives
AT aranamiriam roleofpostbioticsindiabetesmellituscurrentknowledgeandfutureperspectives
AT urtasunraquel roleofpostbioticsindiabetesmellituscurrentknowledgeandfutureperspectives
AT encioignacioj roleofpostbioticsindiabetesmellituscurrentknowledgeandfutureperspectives
AT barajasmiguel roleofpostbioticsindiabetesmellituscurrentknowledgeandfutureperspectives