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Role of Alternative Splicing in Regulating Host Response to Viral Infection
The importance of transcriptional regulation of host genes in innate immunity against viral infection has been widely recognized. More recently, post-transcriptional regulatory mechanisms have gained appreciation as an additional and important layer of regulation to fine-tune host immune responses....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306335/ https://www.ncbi.nlm.nih.gov/pubmed/34359890 http://dx.doi.org/10.3390/cells10071720 |
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author | Liao, Kuo-Chieh Garcia-Blanco, Mariano A. |
author_facet | Liao, Kuo-Chieh Garcia-Blanco, Mariano A. |
author_sort | Liao, Kuo-Chieh |
collection | PubMed |
description | The importance of transcriptional regulation of host genes in innate immunity against viral infection has been widely recognized. More recently, post-transcriptional regulatory mechanisms have gained appreciation as an additional and important layer of regulation to fine-tune host immune responses. Here, we review the functional significance of alternative splicing in innate immune responses to viral infection. We describe how several central components of the Type I and III interferon pathways encode spliced isoforms to regulate IFN activation and function. Additionally, the functional roles of splicing factors and modulators in antiviral immunity are discussed. Lastly, we discuss how cell death pathways are regulated by alternative splicing as well as the potential role of this regulation on host immunity and viral infection. Altogether, these studies highlight the importance of RNA splicing in regulating host–virus interactions and suggest a role in downregulating antiviral innate immunity; this may be critical to prevent pathological inflammation. |
format | Online Article Text |
id | pubmed-8306335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83063352021-07-25 Role of Alternative Splicing in Regulating Host Response to Viral Infection Liao, Kuo-Chieh Garcia-Blanco, Mariano A. Cells Review The importance of transcriptional regulation of host genes in innate immunity against viral infection has been widely recognized. More recently, post-transcriptional regulatory mechanisms have gained appreciation as an additional and important layer of regulation to fine-tune host immune responses. Here, we review the functional significance of alternative splicing in innate immune responses to viral infection. We describe how several central components of the Type I and III interferon pathways encode spliced isoforms to regulate IFN activation and function. Additionally, the functional roles of splicing factors and modulators in antiviral immunity are discussed. Lastly, we discuss how cell death pathways are regulated by alternative splicing as well as the potential role of this regulation on host immunity and viral infection. Altogether, these studies highlight the importance of RNA splicing in regulating host–virus interactions and suggest a role in downregulating antiviral innate immunity; this may be critical to prevent pathological inflammation. MDPI 2021-07-08 /pmc/articles/PMC8306335/ /pubmed/34359890 http://dx.doi.org/10.3390/cells10071720 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liao, Kuo-Chieh Garcia-Blanco, Mariano A. Role of Alternative Splicing in Regulating Host Response to Viral Infection |
title | Role of Alternative Splicing in Regulating Host Response to Viral Infection |
title_full | Role of Alternative Splicing in Regulating Host Response to Viral Infection |
title_fullStr | Role of Alternative Splicing in Regulating Host Response to Viral Infection |
title_full_unstemmed | Role of Alternative Splicing in Regulating Host Response to Viral Infection |
title_short | Role of Alternative Splicing in Regulating Host Response to Viral Infection |
title_sort | role of alternative splicing in regulating host response to viral infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306335/ https://www.ncbi.nlm.nih.gov/pubmed/34359890 http://dx.doi.org/10.3390/cells10071720 |
work_keys_str_mv | AT liaokuochieh roleofalternativesplicinginregulatinghostresponsetoviralinfection AT garciablancomarianoa roleofalternativesplicinginregulatinghostresponsetoviralinfection |