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Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion
Retinal vein occlusion (RVO) is a heterogenous disorder in which the formation of a thrombus results in the retinal venous system narrowing and obstructing venous return from the retinal circulation. The pathogenesis of RVO remains uncertain, but it is believed to be multifactorial and to depend on...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306401/ https://www.ncbi.nlm.nih.gov/pubmed/34300244 http://dx.doi.org/10.3390/jcm10143080 |
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author | Marcinkowska, Adrianna Cisiecki, Slawomir Rozalski, Marcin |
author_facet | Marcinkowska, Adrianna Cisiecki, Slawomir Rozalski, Marcin |
author_sort | Marcinkowska, Adrianna |
collection | PubMed |
description | Retinal vein occlusion (RVO) is a heterogenous disorder in which the formation of a thrombus results in the retinal venous system narrowing and obstructing venous return from the retinal circulation. The pathogenesis of RVO remains uncertain, but it is believed to be multifactorial and to depend on both local and systemic factors, which can be divided into vascular, platelet, and hypercoagulable factors. The vascular factors include dyslipidaemia, high blood pressure, and diabetes mellitus. Regarding the platelet factors, platelet function, mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (PLCR) play key roles in the diagnosis of retinal vein occlusion and should be monitored. Nevertheless, the role of a hypercoagulable state in retinal vein occlusion remains unclear and requires further studies. Therefore, the following article will present the risk factors of RVO associated with coagulation disorders, as well as the acquired and genetic risk factors of thrombophilia. According to Virchow’s triad, all factors mentioned above lead to thrombus formation, which causes pathophysiological changes inside venous vessels in the fundus of the eye, which in turn results in the vessel occlusion. Therefore, a diagnosis of retinal vein occlusion should be based on both eye examination and general examination, including laboratory tests. |
format | Online Article Text |
id | pubmed-8306401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83064012021-07-25 Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion Marcinkowska, Adrianna Cisiecki, Slawomir Rozalski, Marcin J Clin Med Review Retinal vein occlusion (RVO) is a heterogenous disorder in which the formation of a thrombus results in the retinal venous system narrowing and obstructing venous return from the retinal circulation. The pathogenesis of RVO remains uncertain, but it is believed to be multifactorial and to depend on both local and systemic factors, which can be divided into vascular, platelet, and hypercoagulable factors. The vascular factors include dyslipidaemia, high blood pressure, and diabetes mellitus. Regarding the platelet factors, platelet function, mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (PLCR) play key roles in the diagnosis of retinal vein occlusion and should be monitored. Nevertheless, the role of a hypercoagulable state in retinal vein occlusion remains unclear and requires further studies. Therefore, the following article will present the risk factors of RVO associated with coagulation disorders, as well as the acquired and genetic risk factors of thrombophilia. According to Virchow’s triad, all factors mentioned above lead to thrombus formation, which causes pathophysiological changes inside venous vessels in the fundus of the eye, which in turn results in the vessel occlusion. Therefore, a diagnosis of retinal vein occlusion should be based on both eye examination and general examination, including laboratory tests. MDPI 2021-07-12 /pmc/articles/PMC8306401/ /pubmed/34300244 http://dx.doi.org/10.3390/jcm10143080 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Marcinkowska, Adrianna Cisiecki, Slawomir Rozalski, Marcin Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion |
title | Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion |
title_full | Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion |
title_fullStr | Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion |
title_full_unstemmed | Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion |
title_short | Platelet and Thrombophilia-Related Risk Factors of Retinal Vein Occlusion |
title_sort | platelet and thrombophilia-related risk factors of retinal vein occlusion |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306401/ https://www.ncbi.nlm.nih.gov/pubmed/34300244 http://dx.doi.org/10.3390/jcm10143080 |
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