Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines

Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop...

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Detalles Bibliográficos
Autores principales: Aksenov, Alexander V., Grishin, Igor Yu., Aksenov, Nicolai A., Malyuga, Vladimir V., Aksenov, Dmitrii A., Nobi, Mezvah A., Rubin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306411/
https://www.ncbi.nlm.nih.gov/pubmed/34299549
http://dx.doi.org/10.3390/molecules26144274
Descripción
Sumario:Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.

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