Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines

Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop...

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Autores principales: Aksenov, Alexander V., Grishin, Igor Yu., Aksenov, Nicolai A., Malyuga, Vladimir V., Aksenov, Dmitrii A., Nobi, Mezvah A., Rubin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306411/
https://www.ncbi.nlm.nih.gov/pubmed/34299549
http://dx.doi.org/10.3390/molecules26144274
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author Aksenov, Alexander V.
Grishin, Igor Yu.
Aksenov, Nicolai A.
Malyuga, Vladimir V.
Aksenov, Dmitrii A.
Nobi, Mezvah A.
Rubin, Michael
author_facet Aksenov, Alexander V.
Grishin, Igor Yu.
Aksenov, Nicolai A.
Malyuga, Vladimir V.
Aksenov, Dmitrii A.
Nobi, Mezvah A.
Rubin, Michael
author_sort Aksenov, Alexander V.
collection PubMed
description Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.
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spelling pubmed-83064112021-07-25 Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines Aksenov, Alexander V. Grishin, Igor Yu. Aksenov, Nicolai A. Malyuga, Vladimir V. Aksenov, Dmitrii A. Nobi, Mezvah A. Rubin, Michael Molecules Article Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines. MDPI 2021-07-14 /pmc/articles/PMC8306411/ /pubmed/34299549 http://dx.doi.org/10.3390/molecules26144274 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aksenov, Alexander V.
Grishin, Igor Yu.
Aksenov, Nicolai A.
Malyuga, Vladimir V.
Aksenov, Dmitrii A.
Nobi, Mezvah A.
Rubin, Michael
Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
title Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
title_full Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
title_fullStr Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
title_full_unstemmed Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
title_short Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
title_sort electrophilically activated nitroalkanes in synthesis of 3,4-dihydroquinozalines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306411/
https://www.ncbi.nlm.nih.gov/pubmed/34299549
http://dx.doi.org/10.3390/molecules26144274
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