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Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease

Betatrophin, a liver hormone, regulates glucose and lipid metabolism. We investigated the betatrophin levels in nonalcoholic fatty liver disease (NAFLD) and searched for any relationship with histological severity and metabolic parameters. Fifty males with NAFLD [Nonalcoholic Steatohepatitis (NASH)...

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Autores principales: Sonmez, Alper, Dogru, Teoman, Ercin, Cemal Nuri, Genc, Halil, Celebi, Gurkan, Gurel, Hasan, Tapan, Serkan, Cicek, Ali Fuat, Barcin, Cem, Haymana, Cem, Kirik, Ali, Rizzo, Manfredi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306475/
https://www.ncbi.nlm.nih.gov/pubmed/34203342
http://dx.doi.org/10.3390/metabo11070425
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author Sonmez, Alper
Dogru, Teoman
Ercin, Cemal Nuri
Genc, Halil
Celebi, Gurkan
Gurel, Hasan
Tapan, Serkan
Cicek, Ali Fuat
Barcin, Cem
Haymana, Cem
Kirik, Ali
Rizzo, Manfredi
author_facet Sonmez, Alper
Dogru, Teoman
Ercin, Cemal Nuri
Genc, Halil
Celebi, Gurkan
Gurel, Hasan
Tapan, Serkan
Cicek, Ali Fuat
Barcin, Cem
Haymana, Cem
Kirik, Ali
Rizzo, Manfredi
author_sort Sonmez, Alper
collection PubMed
description Betatrophin, a liver hormone, regulates glucose and lipid metabolism. We investigated the betatrophin levels in nonalcoholic fatty liver disease (NAFLD) and searched for any relationship with histological severity and metabolic parameters. Fifty males with NAFLD [Nonalcoholic Steatohepatitis (NASH) (n = 32); non-NASH (n = 18)] and 30 healthy controls were included. Plasma betatrophin was measured by ELISA method. Insulin sensitivity was assessed by HOMA-IR index. Histological features were scored by the semi quantitative classification and combined as the NAFLD activity score (NAS). Betatrophin levels in the non-NASH group were significantly higher than the controls. Betatrophin was positively correlated to the age, waist circumference, total cholesterol, triglycerides, LDL cholesterol, glucose, insulin, HOMA-IR index and gamma glutamyl transpeptidase levels, and negatively correlated to the steatosis and NAS. In the stepwise linear regression analysis, the triglyceride (β = 0.457, p < 0.001), glucose (β = 0.281, p = 0.02) and NAS (β = −0.260, p = 0.03) were the independent determinants of betatrophin. Betatrophin levels are higher in the early stages of NAFLD and tend to decrease when the disease progresses. This could be an important preliminary mechanistic finding to explain the increased frequency of glucose intolerance during the course of NAFLD.
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spelling pubmed-83064752021-07-25 Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease Sonmez, Alper Dogru, Teoman Ercin, Cemal Nuri Genc, Halil Celebi, Gurkan Gurel, Hasan Tapan, Serkan Cicek, Ali Fuat Barcin, Cem Haymana, Cem Kirik, Ali Rizzo, Manfredi Metabolites Article Betatrophin, a liver hormone, regulates glucose and lipid metabolism. We investigated the betatrophin levels in nonalcoholic fatty liver disease (NAFLD) and searched for any relationship with histological severity and metabolic parameters. Fifty males with NAFLD [Nonalcoholic Steatohepatitis (NASH) (n = 32); non-NASH (n = 18)] and 30 healthy controls were included. Plasma betatrophin was measured by ELISA method. Insulin sensitivity was assessed by HOMA-IR index. Histological features were scored by the semi quantitative classification and combined as the NAFLD activity score (NAS). Betatrophin levels in the non-NASH group were significantly higher than the controls. Betatrophin was positively correlated to the age, waist circumference, total cholesterol, triglycerides, LDL cholesterol, glucose, insulin, HOMA-IR index and gamma glutamyl transpeptidase levels, and negatively correlated to the steatosis and NAS. In the stepwise linear regression analysis, the triglyceride (β = 0.457, p < 0.001), glucose (β = 0.281, p = 0.02) and NAS (β = −0.260, p = 0.03) were the independent determinants of betatrophin. Betatrophin levels are higher in the early stages of NAFLD and tend to decrease when the disease progresses. This could be an important preliminary mechanistic finding to explain the increased frequency of glucose intolerance during the course of NAFLD. MDPI 2021-06-28 /pmc/articles/PMC8306475/ /pubmed/34203342 http://dx.doi.org/10.3390/metabo11070425 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sonmez, Alper
Dogru, Teoman
Ercin, Cemal Nuri
Genc, Halil
Celebi, Gurkan
Gurel, Hasan
Tapan, Serkan
Cicek, Ali Fuat
Barcin, Cem
Haymana, Cem
Kirik, Ali
Rizzo, Manfredi
Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease
title Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease
title_full Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease
title_fullStr Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease
title_full_unstemmed Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease
title_short Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease
title_sort betatrophin levels are related to the early histological findings in nonalcoholic fatty liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306475/
https://www.ncbi.nlm.nih.gov/pubmed/34203342
http://dx.doi.org/10.3390/metabo11070425
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