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Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease
Betatrophin, a liver hormone, regulates glucose and lipid metabolism. We investigated the betatrophin levels in nonalcoholic fatty liver disease (NAFLD) and searched for any relationship with histological severity and metabolic parameters. Fifty males with NAFLD [Nonalcoholic Steatohepatitis (NASH)...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306475/ https://www.ncbi.nlm.nih.gov/pubmed/34203342 http://dx.doi.org/10.3390/metabo11070425 |
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author | Sonmez, Alper Dogru, Teoman Ercin, Cemal Nuri Genc, Halil Celebi, Gurkan Gurel, Hasan Tapan, Serkan Cicek, Ali Fuat Barcin, Cem Haymana, Cem Kirik, Ali Rizzo, Manfredi |
author_facet | Sonmez, Alper Dogru, Teoman Ercin, Cemal Nuri Genc, Halil Celebi, Gurkan Gurel, Hasan Tapan, Serkan Cicek, Ali Fuat Barcin, Cem Haymana, Cem Kirik, Ali Rizzo, Manfredi |
author_sort | Sonmez, Alper |
collection | PubMed |
description | Betatrophin, a liver hormone, regulates glucose and lipid metabolism. We investigated the betatrophin levels in nonalcoholic fatty liver disease (NAFLD) and searched for any relationship with histological severity and metabolic parameters. Fifty males with NAFLD [Nonalcoholic Steatohepatitis (NASH) (n = 32); non-NASH (n = 18)] and 30 healthy controls were included. Plasma betatrophin was measured by ELISA method. Insulin sensitivity was assessed by HOMA-IR index. Histological features were scored by the semi quantitative classification and combined as the NAFLD activity score (NAS). Betatrophin levels in the non-NASH group were significantly higher than the controls. Betatrophin was positively correlated to the age, waist circumference, total cholesterol, triglycerides, LDL cholesterol, glucose, insulin, HOMA-IR index and gamma glutamyl transpeptidase levels, and negatively correlated to the steatosis and NAS. In the stepwise linear regression analysis, the triglyceride (β = 0.457, p < 0.001), glucose (β = 0.281, p = 0.02) and NAS (β = −0.260, p = 0.03) were the independent determinants of betatrophin. Betatrophin levels are higher in the early stages of NAFLD and tend to decrease when the disease progresses. This could be an important preliminary mechanistic finding to explain the increased frequency of glucose intolerance during the course of NAFLD. |
format | Online Article Text |
id | pubmed-8306475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83064752021-07-25 Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease Sonmez, Alper Dogru, Teoman Ercin, Cemal Nuri Genc, Halil Celebi, Gurkan Gurel, Hasan Tapan, Serkan Cicek, Ali Fuat Barcin, Cem Haymana, Cem Kirik, Ali Rizzo, Manfredi Metabolites Article Betatrophin, a liver hormone, regulates glucose and lipid metabolism. We investigated the betatrophin levels in nonalcoholic fatty liver disease (NAFLD) and searched for any relationship with histological severity and metabolic parameters. Fifty males with NAFLD [Nonalcoholic Steatohepatitis (NASH) (n = 32); non-NASH (n = 18)] and 30 healthy controls were included. Plasma betatrophin was measured by ELISA method. Insulin sensitivity was assessed by HOMA-IR index. Histological features were scored by the semi quantitative classification and combined as the NAFLD activity score (NAS). Betatrophin levels in the non-NASH group were significantly higher than the controls. Betatrophin was positively correlated to the age, waist circumference, total cholesterol, triglycerides, LDL cholesterol, glucose, insulin, HOMA-IR index and gamma glutamyl transpeptidase levels, and negatively correlated to the steatosis and NAS. In the stepwise linear regression analysis, the triglyceride (β = 0.457, p < 0.001), glucose (β = 0.281, p = 0.02) and NAS (β = −0.260, p = 0.03) were the independent determinants of betatrophin. Betatrophin levels are higher in the early stages of NAFLD and tend to decrease when the disease progresses. This could be an important preliminary mechanistic finding to explain the increased frequency of glucose intolerance during the course of NAFLD. MDPI 2021-06-28 /pmc/articles/PMC8306475/ /pubmed/34203342 http://dx.doi.org/10.3390/metabo11070425 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sonmez, Alper Dogru, Teoman Ercin, Cemal Nuri Genc, Halil Celebi, Gurkan Gurel, Hasan Tapan, Serkan Cicek, Ali Fuat Barcin, Cem Haymana, Cem Kirik, Ali Rizzo, Manfredi Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease |
title | Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease |
title_full | Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease |
title_fullStr | Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease |
title_full_unstemmed | Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease |
title_short | Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease |
title_sort | betatrophin levels are related to the early histological findings in nonalcoholic fatty liver disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306475/ https://www.ncbi.nlm.nih.gov/pubmed/34203342 http://dx.doi.org/10.3390/metabo11070425 |
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