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Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network

The complexity of genomic medicine can be streamlined by implementing some form of clinical decision support (CDS) to guide clinicians in how to use and interpret personalized data; however, it is not yet clear which strategies are best suited for this purpose. In this study, we used implementation...

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Autores principales: Sperber, Nina R., Dong, Olivia M., Roberts, Megan C., Dexter, Paul, Elsey, Amanda R., Ginsburg, Geoffrey S., Horowitz, Carol R., Johnson, Julie A., Levy, Kenneth D., Ong, Henry, Peterson, Josh F., Pollin, Toni I., Rakhra-Burris, Tejinder, Ramos, Michelle A., Skaar, Todd, Orlando, Lori A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306482/
https://www.ncbi.nlm.nih.gov/pubmed/34357114
http://dx.doi.org/10.3390/jpm11070647
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author Sperber, Nina R.
Dong, Olivia M.
Roberts, Megan C.
Dexter, Paul
Elsey, Amanda R.
Ginsburg, Geoffrey S.
Horowitz, Carol R.
Johnson, Julie A.
Levy, Kenneth D.
Ong, Henry
Peterson, Josh F.
Pollin, Toni I.
Rakhra-Burris, Tejinder
Ramos, Michelle A.
Skaar, Todd
Orlando, Lori A.
author_facet Sperber, Nina R.
Dong, Olivia M.
Roberts, Megan C.
Dexter, Paul
Elsey, Amanda R.
Ginsburg, Geoffrey S.
Horowitz, Carol R.
Johnson, Julie A.
Levy, Kenneth D.
Ong, Henry
Peterson, Josh F.
Pollin, Toni I.
Rakhra-Burris, Tejinder
Ramos, Michelle A.
Skaar, Todd
Orlando, Lori A.
author_sort Sperber, Nina R.
collection PubMed
description The complexity of genomic medicine can be streamlined by implementing some form of clinical decision support (CDS) to guide clinicians in how to use and interpret personalized data; however, it is not yet clear which strategies are best suited for this purpose. In this study, we used implementation science to identify common strategies for applying provider-based CDS interventions across six genomic medicine clinical research projects funded by an NIH consortium. Each project’s strategies were elicited via a structured survey derived from a typology of implementation strategies, the Expert Recommendations for Implementing Change (ERIC), and follow-up interviews guided by both implementation strategy reporting criteria and a planning framework, RE-AIM, to obtain more detail about implementation strategies and desired outcomes. We found that, on average, the three pharmacogenomics implementation projects used more strategies than the disease-focused projects. Overall, projects had four implementation strategies in common; however, operationalization of each differed in accordance with each study’s implementation outcomes. These four common strategies may be important for precision medicine program implementation, and pharmacogenomics may require more integration into clinical care. Understanding how and why these strategies were successfully employed could be useful for others implementing genomic or precision medicine programs in different contexts.
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spelling pubmed-83064822021-07-25 Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network Sperber, Nina R. Dong, Olivia M. Roberts, Megan C. Dexter, Paul Elsey, Amanda R. Ginsburg, Geoffrey S. Horowitz, Carol R. Johnson, Julie A. Levy, Kenneth D. Ong, Henry Peterson, Josh F. Pollin, Toni I. Rakhra-Burris, Tejinder Ramos, Michelle A. Skaar, Todd Orlando, Lori A. J Pers Med Article The complexity of genomic medicine can be streamlined by implementing some form of clinical decision support (CDS) to guide clinicians in how to use and interpret personalized data; however, it is not yet clear which strategies are best suited for this purpose. In this study, we used implementation science to identify common strategies for applying provider-based CDS interventions across six genomic medicine clinical research projects funded by an NIH consortium. Each project’s strategies were elicited via a structured survey derived from a typology of implementation strategies, the Expert Recommendations for Implementing Change (ERIC), and follow-up interviews guided by both implementation strategy reporting criteria and a planning framework, RE-AIM, to obtain more detail about implementation strategies and desired outcomes. We found that, on average, the three pharmacogenomics implementation projects used more strategies than the disease-focused projects. Overall, projects had four implementation strategies in common; however, operationalization of each differed in accordance with each study’s implementation outcomes. These four common strategies may be important for precision medicine program implementation, and pharmacogenomics may require more integration into clinical care. Understanding how and why these strategies were successfully employed could be useful for others implementing genomic or precision medicine programs in different contexts. MDPI 2021-07-08 /pmc/articles/PMC8306482/ /pubmed/34357114 http://dx.doi.org/10.3390/jpm11070647 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sperber, Nina R.
Dong, Olivia M.
Roberts, Megan C.
Dexter, Paul
Elsey, Amanda R.
Ginsburg, Geoffrey S.
Horowitz, Carol R.
Johnson, Julie A.
Levy, Kenneth D.
Ong, Henry
Peterson, Josh F.
Pollin, Toni I.
Rakhra-Burris, Tejinder
Ramos, Michelle A.
Skaar, Todd
Orlando, Lori A.
Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network
title Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network
title_full Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network
title_fullStr Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network
title_full_unstemmed Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network
title_short Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network
title_sort strategies to integrate genomic medicine into clinical care: evidence from the ignite network
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306482/
https://www.ncbi.nlm.nih.gov/pubmed/34357114
http://dx.doi.org/10.3390/jpm11070647
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