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Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network
The complexity of genomic medicine can be streamlined by implementing some form of clinical decision support (CDS) to guide clinicians in how to use and interpret personalized data; however, it is not yet clear which strategies are best suited for this purpose. In this study, we used implementation...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306482/ https://www.ncbi.nlm.nih.gov/pubmed/34357114 http://dx.doi.org/10.3390/jpm11070647 |
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author | Sperber, Nina R. Dong, Olivia M. Roberts, Megan C. Dexter, Paul Elsey, Amanda R. Ginsburg, Geoffrey S. Horowitz, Carol R. Johnson, Julie A. Levy, Kenneth D. Ong, Henry Peterson, Josh F. Pollin, Toni I. Rakhra-Burris, Tejinder Ramos, Michelle A. Skaar, Todd Orlando, Lori A. |
author_facet | Sperber, Nina R. Dong, Olivia M. Roberts, Megan C. Dexter, Paul Elsey, Amanda R. Ginsburg, Geoffrey S. Horowitz, Carol R. Johnson, Julie A. Levy, Kenneth D. Ong, Henry Peterson, Josh F. Pollin, Toni I. Rakhra-Burris, Tejinder Ramos, Michelle A. Skaar, Todd Orlando, Lori A. |
author_sort | Sperber, Nina R. |
collection | PubMed |
description | The complexity of genomic medicine can be streamlined by implementing some form of clinical decision support (CDS) to guide clinicians in how to use and interpret personalized data; however, it is not yet clear which strategies are best suited for this purpose. In this study, we used implementation science to identify common strategies for applying provider-based CDS interventions across six genomic medicine clinical research projects funded by an NIH consortium. Each project’s strategies were elicited via a structured survey derived from a typology of implementation strategies, the Expert Recommendations for Implementing Change (ERIC), and follow-up interviews guided by both implementation strategy reporting criteria and a planning framework, RE-AIM, to obtain more detail about implementation strategies and desired outcomes. We found that, on average, the three pharmacogenomics implementation projects used more strategies than the disease-focused projects. Overall, projects had four implementation strategies in common; however, operationalization of each differed in accordance with each study’s implementation outcomes. These four common strategies may be important for precision medicine program implementation, and pharmacogenomics may require more integration into clinical care. Understanding how and why these strategies were successfully employed could be useful for others implementing genomic or precision medicine programs in different contexts. |
format | Online Article Text |
id | pubmed-8306482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83064822021-07-25 Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network Sperber, Nina R. Dong, Olivia M. Roberts, Megan C. Dexter, Paul Elsey, Amanda R. Ginsburg, Geoffrey S. Horowitz, Carol R. Johnson, Julie A. Levy, Kenneth D. Ong, Henry Peterson, Josh F. Pollin, Toni I. Rakhra-Burris, Tejinder Ramos, Michelle A. Skaar, Todd Orlando, Lori A. J Pers Med Article The complexity of genomic medicine can be streamlined by implementing some form of clinical decision support (CDS) to guide clinicians in how to use and interpret personalized data; however, it is not yet clear which strategies are best suited for this purpose. In this study, we used implementation science to identify common strategies for applying provider-based CDS interventions across six genomic medicine clinical research projects funded by an NIH consortium. Each project’s strategies were elicited via a structured survey derived from a typology of implementation strategies, the Expert Recommendations for Implementing Change (ERIC), and follow-up interviews guided by both implementation strategy reporting criteria and a planning framework, RE-AIM, to obtain more detail about implementation strategies and desired outcomes. We found that, on average, the three pharmacogenomics implementation projects used more strategies than the disease-focused projects. Overall, projects had four implementation strategies in common; however, operationalization of each differed in accordance with each study’s implementation outcomes. These four common strategies may be important for precision medicine program implementation, and pharmacogenomics may require more integration into clinical care. Understanding how and why these strategies were successfully employed could be useful for others implementing genomic or precision medicine programs in different contexts. MDPI 2021-07-08 /pmc/articles/PMC8306482/ /pubmed/34357114 http://dx.doi.org/10.3390/jpm11070647 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sperber, Nina R. Dong, Olivia M. Roberts, Megan C. Dexter, Paul Elsey, Amanda R. Ginsburg, Geoffrey S. Horowitz, Carol R. Johnson, Julie A. Levy, Kenneth D. Ong, Henry Peterson, Josh F. Pollin, Toni I. Rakhra-Burris, Tejinder Ramos, Michelle A. Skaar, Todd Orlando, Lori A. Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network |
title | Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network |
title_full | Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network |
title_fullStr | Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network |
title_full_unstemmed | Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network |
title_short | Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network |
title_sort | strategies to integrate genomic medicine into clinical care: evidence from the ignite network |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306482/ https://www.ncbi.nlm.nih.gov/pubmed/34357114 http://dx.doi.org/10.3390/jpm11070647 |
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