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Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack

Background and objectives: ischemic stroke (IS) is among the most frequent causes of death worldwide; thus, it is of paramount relevance to know predisposing factors that may help to identify and treat the high-risk subjects. Materials and Methods:we tested nine variants in genes involved in thrombo...

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Autores principales: Cernera, Gustavo, Comegna, Marika, Gelzo, Monica, Savoia, Marcella, Bruzzese, Dario, Mormile, Mauro, Zarrilli, Federica, Amato, Felice, Micco, Pierpaolo Di, Castaldo, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306646/
https://www.ncbi.nlm.nih.gov/pubmed/34357004
http://dx.doi.org/10.3390/medicina57070723
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author Cernera, Gustavo
Comegna, Marika
Gelzo, Monica
Savoia, Marcella
Bruzzese, Dario
Mormile, Mauro
Zarrilli, Federica
Amato, Felice
Micco, Pierpaolo Di
Castaldo, Giuseppe
author_facet Cernera, Gustavo
Comegna, Marika
Gelzo, Monica
Savoia, Marcella
Bruzzese, Dario
Mormile, Mauro
Zarrilli, Federica
Amato, Felice
Micco, Pierpaolo Di
Castaldo, Giuseppe
author_sort Cernera, Gustavo
collection PubMed
description Background and objectives: ischemic stroke (IS) is among the most frequent causes of death worldwide; thus, it is of paramount relevance to know predisposing factors that may help to identify and treat the high-risk subjects. Materials and Methods:we tested nine variants in genes involved in thrombotic pathway in 282 patients that experienced IS and 87 that had transient ischemic attacks (TIA) in comparison to 430 subjects from the general population (GP) of the same geographic area (southern Italy). We included cases of young and child IS to evaluate the eventual differences in the role of the analyzed variants. Results: we did not observe significant differences between TIA and the GP for any of the variants, while the allele frequencies of methylene-tetrahydrofolate reductase (MTHFR) C677T, beta-fibrinogen -455G>A and factor (FXIII) V34L were significantly higher in patients with IS than in the subjects from the GP. No significant interaction was observed with sex. Conclusions: the present data argue that some gene variants have a role in IS and this appears to be an interesting possibility to be pursued in large population studies to help design specific strategies for IS prevention.
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spelling pubmed-83066462021-07-25 Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack Cernera, Gustavo Comegna, Marika Gelzo, Monica Savoia, Marcella Bruzzese, Dario Mormile, Mauro Zarrilli, Federica Amato, Felice Micco, Pierpaolo Di Castaldo, Giuseppe Medicina (Kaunas) Article Background and objectives: ischemic stroke (IS) is among the most frequent causes of death worldwide; thus, it is of paramount relevance to know predisposing factors that may help to identify and treat the high-risk subjects. Materials and Methods:we tested nine variants in genes involved in thrombotic pathway in 282 patients that experienced IS and 87 that had transient ischemic attacks (TIA) in comparison to 430 subjects from the general population (GP) of the same geographic area (southern Italy). We included cases of young and child IS to evaluate the eventual differences in the role of the analyzed variants. Results: we did not observe significant differences between TIA and the GP for any of the variants, while the allele frequencies of methylene-tetrahydrofolate reductase (MTHFR) C677T, beta-fibrinogen -455G>A and factor (FXIII) V34L were significantly higher in patients with IS than in the subjects from the GP. No significant interaction was observed with sex. Conclusions: the present data argue that some gene variants have a role in IS and this appears to be an interesting possibility to be pursued in large population studies to help design specific strategies for IS prevention. MDPI 2021-07-17 /pmc/articles/PMC8306646/ /pubmed/34357004 http://dx.doi.org/10.3390/medicina57070723 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cernera, Gustavo
Comegna, Marika
Gelzo, Monica
Savoia, Marcella
Bruzzese, Dario
Mormile, Mauro
Zarrilli, Federica
Amato, Felice
Micco, Pierpaolo Di
Castaldo, Giuseppe
Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack
title Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack
title_full Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack
title_fullStr Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack
title_full_unstemmed Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack
title_short Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack
title_sort molecular analysis of prothrombotic gene variants in patients with acute ischemic stroke and with transient ischemic attack
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306646/
https://www.ncbi.nlm.nih.gov/pubmed/34357004
http://dx.doi.org/10.3390/medicina57070723
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