Cargando…
Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack
Background and objectives: ischemic stroke (IS) is among the most frequent causes of death worldwide; thus, it is of paramount relevance to know predisposing factors that may help to identify and treat the high-risk subjects. Materials and Methods:we tested nine variants in genes involved in thrombo...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306646/ https://www.ncbi.nlm.nih.gov/pubmed/34357004 http://dx.doi.org/10.3390/medicina57070723 |
_version_ | 1783727860485193728 |
---|---|
author | Cernera, Gustavo Comegna, Marika Gelzo, Monica Savoia, Marcella Bruzzese, Dario Mormile, Mauro Zarrilli, Federica Amato, Felice Micco, Pierpaolo Di Castaldo, Giuseppe |
author_facet | Cernera, Gustavo Comegna, Marika Gelzo, Monica Savoia, Marcella Bruzzese, Dario Mormile, Mauro Zarrilli, Federica Amato, Felice Micco, Pierpaolo Di Castaldo, Giuseppe |
author_sort | Cernera, Gustavo |
collection | PubMed |
description | Background and objectives: ischemic stroke (IS) is among the most frequent causes of death worldwide; thus, it is of paramount relevance to know predisposing factors that may help to identify and treat the high-risk subjects. Materials and Methods:we tested nine variants in genes involved in thrombotic pathway in 282 patients that experienced IS and 87 that had transient ischemic attacks (TIA) in comparison to 430 subjects from the general population (GP) of the same geographic area (southern Italy). We included cases of young and child IS to evaluate the eventual differences in the role of the analyzed variants. Results: we did not observe significant differences between TIA and the GP for any of the variants, while the allele frequencies of methylene-tetrahydrofolate reductase (MTHFR) C677T, beta-fibrinogen -455G>A and factor (FXIII) V34L were significantly higher in patients with IS than in the subjects from the GP. No significant interaction was observed with sex. Conclusions: the present data argue that some gene variants have a role in IS and this appears to be an interesting possibility to be pursued in large population studies to help design specific strategies for IS prevention. |
format | Online Article Text |
id | pubmed-8306646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83066462021-07-25 Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack Cernera, Gustavo Comegna, Marika Gelzo, Monica Savoia, Marcella Bruzzese, Dario Mormile, Mauro Zarrilli, Federica Amato, Felice Micco, Pierpaolo Di Castaldo, Giuseppe Medicina (Kaunas) Article Background and objectives: ischemic stroke (IS) is among the most frequent causes of death worldwide; thus, it is of paramount relevance to know predisposing factors that may help to identify and treat the high-risk subjects. Materials and Methods:we tested nine variants in genes involved in thrombotic pathway in 282 patients that experienced IS and 87 that had transient ischemic attacks (TIA) in comparison to 430 subjects from the general population (GP) of the same geographic area (southern Italy). We included cases of young and child IS to evaluate the eventual differences in the role of the analyzed variants. Results: we did not observe significant differences between TIA and the GP for any of the variants, while the allele frequencies of methylene-tetrahydrofolate reductase (MTHFR) C677T, beta-fibrinogen -455G>A and factor (FXIII) V34L were significantly higher in patients with IS than in the subjects from the GP. No significant interaction was observed with sex. Conclusions: the present data argue that some gene variants have a role in IS and this appears to be an interesting possibility to be pursued in large population studies to help design specific strategies for IS prevention. MDPI 2021-07-17 /pmc/articles/PMC8306646/ /pubmed/34357004 http://dx.doi.org/10.3390/medicina57070723 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cernera, Gustavo Comegna, Marika Gelzo, Monica Savoia, Marcella Bruzzese, Dario Mormile, Mauro Zarrilli, Federica Amato, Felice Micco, Pierpaolo Di Castaldo, Giuseppe Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack |
title | Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack |
title_full | Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack |
title_fullStr | Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack |
title_full_unstemmed | Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack |
title_short | Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack |
title_sort | molecular analysis of prothrombotic gene variants in patients with acute ischemic stroke and with transient ischemic attack |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306646/ https://www.ncbi.nlm.nih.gov/pubmed/34357004 http://dx.doi.org/10.3390/medicina57070723 |
work_keys_str_mv | AT cerneragustavo molecularanalysisofprothromboticgenevariantsinpatientswithacuteischemicstrokeandwithtransientischemicattack AT comegnamarika molecularanalysisofprothromboticgenevariantsinpatientswithacuteischemicstrokeandwithtransientischemicattack AT gelzomonica molecularanalysisofprothromboticgenevariantsinpatientswithacuteischemicstrokeandwithtransientischemicattack AT savoiamarcella molecularanalysisofprothromboticgenevariantsinpatientswithacuteischemicstrokeandwithtransientischemicattack AT bruzzesedario molecularanalysisofprothromboticgenevariantsinpatientswithacuteischemicstrokeandwithtransientischemicattack AT mormilemauro molecularanalysisofprothromboticgenevariantsinpatientswithacuteischemicstrokeandwithtransientischemicattack AT zarrillifederica molecularanalysisofprothromboticgenevariantsinpatientswithacuteischemicstrokeandwithtransientischemicattack AT amatofelice molecularanalysisofprothromboticgenevariantsinpatientswithacuteischemicstrokeandwithtransientischemicattack AT miccopierpaolodi molecularanalysisofprothromboticgenevariantsinpatientswithacuteischemicstrokeandwithtransientischemicattack AT castaldogiuseppe molecularanalysisofprothromboticgenevariantsinpatientswithacuteischemicstrokeandwithtransientischemicattack |