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Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies

The past decade has witnessed a surge in epidemiological studies that have explored the relationship between the oral microbiome and oral cancer. Owing to the diversity of the published data, a comprehensive systematic overview of the currently available evidence is critical. This review summarises...

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Autores principales: Su Mun, Lee, Wye Lum, See, Kong Yuiin Sze, Genevieve, Hock Yoong, Cheong, Ching Yung, Kwek, Kah Lok, Liong, Gopinath, Divya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306663/
https://www.ncbi.nlm.nih.gov/pubmed/34299675
http://dx.doi.org/10.3390/ijerph18147224
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author Su Mun, Lee
Wye Lum, See
Kong Yuiin Sze, Genevieve
Hock Yoong, Cheong
Ching Yung, Kwek
Kah Lok, Liong
Gopinath, Divya
author_facet Su Mun, Lee
Wye Lum, See
Kong Yuiin Sze, Genevieve
Hock Yoong, Cheong
Ching Yung, Kwek
Kah Lok, Liong
Gopinath, Divya
author_sort Su Mun, Lee
collection PubMed
description The past decade has witnessed a surge in epidemiological studies that have explored the relationship between the oral microbiome and oral cancer. Owing to the diversity of the published data, a comprehensive systematic overview of the currently available evidence is critical. This review summarises the current evidence on the metagenomic studies on the oral microbiome in oral cancer. A systematic search was conducted in Medline and Embase databases to identify original studies examining the differences in the oral microbiome of oral cancer cases and controls. A total of twenty-six studies were identified that reported differences in microbial abundance between oral squamous cell carcinoma (OSCC) and controls. Although almost all the studies identified microbial dysbiosis to be associated with oral cancer, the detailed qualitative analysis did not reveal the presence/abundance of any individual bacteria or a consortium to be consistently enriched in OSCC samples across the studies. Interestingly, few studies reported a surge of periodontopathogenic taxa, especially Fusobacteria, whereas others demonstrated a depletion of commensal taxa Streptococci. Considerable heterogeneity could be identified in the parameters used for designing the studies as well as reporting the microbial data. If microbiome data needs to be translated in the future, to complement the clinical parameters for diagnosis and prognosis of oral cancer, further studies with the integration of clinical variables, adequate statistical power, reproducible methods, and models are required.
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spelling pubmed-83066632021-07-25 Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies Su Mun, Lee Wye Lum, See Kong Yuiin Sze, Genevieve Hock Yoong, Cheong Ching Yung, Kwek Kah Lok, Liong Gopinath, Divya Int J Environ Res Public Health Review The past decade has witnessed a surge in epidemiological studies that have explored the relationship between the oral microbiome and oral cancer. Owing to the diversity of the published data, a comprehensive systematic overview of the currently available evidence is critical. This review summarises the current evidence on the metagenomic studies on the oral microbiome in oral cancer. A systematic search was conducted in Medline and Embase databases to identify original studies examining the differences in the oral microbiome of oral cancer cases and controls. A total of twenty-six studies were identified that reported differences in microbial abundance between oral squamous cell carcinoma (OSCC) and controls. Although almost all the studies identified microbial dysbiosis to be associated with oral cancer, the detailed qualitative analysis did not reveal the presence/abundance of any individual bacteria or a consortium to be consistently enriched in OSCC samples across the studies. Interestingly, few studies reported a surge of periodontopathogenic taxa, especially Fusobacteria, whereas others demonstrated a depletion of commensal taxa Streptococci. Considerable heterogeneity could be identified in the parameters used for designing the studies as well as reporting the microbial data. If microbiome data needs to be translated in the future, to complement the clinical parameters for diagnosis and prognosis of oral cancer, further studies with the integration of clinical variables, adequate statistical power, reproducible methods, and models are required. MDPI 2021-07-06 /pmc/articles/PMC8306663/ /pubmed/34299675 http://dx.doi.org/10.3390/ijerph18147224 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Su Mun, Lee
Wye Lum, See
Kong Yuiin Sze, Genevieve
Hock Yoong, Cheong
Ching Yung, Kwek
Kah Lok, Liong
Gopinath, Divya
Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies
title Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies
title_full Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies
title_fullStr Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies
title_full_unstemmed Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies
title_short Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies
title_sort association of microbiome with oral squamous cell carcinoma: a systematic review of the metagenomic studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306663/
https://www.ncbi.nlm.nih.gov/pubmed/34299675
http://dx.doi.org/10.3390/ijerph18147224
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