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Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR
SIMPLE SUMMARY: It is important to understand the impact of viremia on the survival of hepatocellular carcinoma (HCC) in hepatitis C patients. This study aimed to investigate the characteristics and survival between hepatitis C patients with and without viremia at HCC diagnosis. We enrolled 1,389 HC...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306695/ https://www.ncbi.nlm.nih.gov/pubmed/34298669 http://dx.doi.org/10.3390/cancers13143455 |
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author | Yeh, Ming-Lun Liang, Po-Cheng Tsai, Pei-Chien Wang, Shu-Chi Leong, Jennifer Ogawa, Eiichi Jun, Dae Won Tseng, Cheng-Hao Landis, Charles Tanaka, Yasuhito Huang, Chung-Feng Hayashi, Jun Hsu, Yao-Chun Huang, Jee-Fu Dai, Chia-Yen Chuang, Wan-Long Nguyen, Mindie H. Yu, Ming-Lung |
author_facet | Yeh, Ming-Lun Liang, Po-Cheng Tsai, Pei-Chien Wang, Shu-Chi Leong, Jennifer Ogawa, Eiichi Jun, Dae Won Tseng, Cheng-Hao Landis, Charles Tanaka, Yasuhito Huang, Chung-Feng Hayashi, Jun Hsu, Yao-Chun Huang, Jee-Fu Dai, Chia-Yen Chuang, Wan-Long Nguyen, Mindie H. Yu, Ming-Lung |
author_sort | Yeh, Ming-Lun |
collection | PubMed |
description | SIMPLE SUMMARY: It is important to understand the impact of viremia on the survival of hepatocellular carcinoma (HCC) in hepatitis C patients. This study aimed to investigate the characteristics and survival between hepatitis C patients with and without viremia at HCC diagnosis. We enrolled 1,389 HCC patients, including 301 with HCC developed after hepatitis C eradication (post-SVR HCC) and 1,088 with hepatitis C viremia (viremic HCC). Post-SVR HCC patients had better liver function, earlier tumor stages and higher median survival than viremic HCC patients. But post-SVR HCC was not independently associated with survival on further multivariate analysis. On sub-analysis, viremic HCC patients who subsequently eradicated hepatitis C had higher median survival and was also significantly associated with lower mortality as compared to post-SVR HCC. Therefore, the advantages in clinical and tumor characters determined the better overall survival of post-SVR HCC patients; however, eradication of hepatitis C after HCC also improved survival. ABSTRACT: The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, p < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (p < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival. |
format | Online Article Text |
id | pubmed-8306695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83066952021-07-25 Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR Yeh, Ming-Lun Liang, Po-Cheng Tsai, Pei-Chien Wang, Shu-Chi Leong, Jennifer Ogawa, Eiichi Jun, Dae Won Tseng, Cheng-Hao Landis, Charles Tanaka, Yasuhito Huang, Chung-Feng Hayashi, Jun Hsu, Yao-Chun Huang, Jee-Fu Dai, Chia-Yen Chuang, Wan-Long Nguyen, Mindie H. Yu, Ming-Lung Cancers (Basel) Article SIMPLE SUMMARY: It is important to understand the impact of viremia on the survival of hepatocellular carcinoma (HCC) in hepatitis C patients. This study aimed to investigate the characteristics and survival between hepatitis C patients with and without viremia at HCC diagnosis. We enrolled 1,389 HCC patients, including 301 with HCC developed after hepatitis C eradication (post-SVR HCC) and 1,088 with hepatitis C viremia (viremic HCC). Post-SVR HCC patients had better liver function, earlier tumor stages and higher median survival than viremic HCC patients. But post-SVR HCC was not independently associated with survival on further multivariate analysis. On sub-analysis, viremic HCC patients who subsequently eradicated hepatitis C had higher median survival and was also significantly associated with lower mortality as compared to post-SVR HCC. Therefore, the advantages in clinical and tumor characters determined the better overall survival of post-SVR HCC patients; however, eradication of hepatitis C after HCC also improved survival. ABSTRACT: The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, p < 0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (p < 0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients; however, HCV eradication after HCC development was also associated with improved survival. MDPI 2021-07-09 /pmc/articles/PMC8306695/ /pubmed/34298669 http://dx.doi.org/10.3390/cancers13143455 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yeh, Ming-Lun Liang, Po-Cheng Tsai, Pei-Chien Wang, Shu-Chi Leong, Jennifer Ogawa, Eiichi Jun, Dae Won Tseng, Cheng-Hao Landis, Charles Tanaka, Yasuhito Huang, Chung-Feng Hayashi, Jun Hsu, Yao-Chun Huang, Jee-Fu Dai, Chia-Yen Chuang, Wan-Long Nguyen, Mindie H. Yu, Ming-Lung Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR |
title | Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR |
title_full | Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR |
title_fullStr | Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR |
title_full_unstemmed | Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR |
title_short | Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR |
title_sort | characteristics and survival outcomes of hepatocellular carcinoma developed after hcv svr |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306695/ https://www.ncbi.nlm.nih.gov/pubmed/34298669 http://dx.doi.org/10.3390/cancers13143455 |
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