Cargando…

Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age

Few data are available in the literature regarding Pneumocystis jirovecii infection in children under 3 years old. This retrospective cohort study aimed to describe medically relevant information among them. All children under 3 years old treated in the same medical units from April 2014 to August 2...

Descripción completa

Detalles Bibliográficos
Autores principales: Menu, Estelle, Driouich, Jean-Sélim, Luciani, Léa, Morand, Aurélie, Ranque, Stéphane, L’Ollivier, Coralie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306698/
https://www.ncbi.nlm.nih.gov/pubmed/34356925
http://dx.doi.org/10.3390/jof7070546
_version_ 1783727873292500992
author Menu, Estelle
Driouich, Jean-Sélim
Luciani, Léa
Morand, Aurélie
Ranque, Stéphane
L’Ollivier, Coralie
author_facet Menu, Estelle
Driouich, Jean-Sélim
Luciani, Léa
Morand, Aurélie
Ranque, Stéphane
L’Ollivier, Coralie
author_sort Menu, Estelle
collection PubMed
description Few data are available in the literature regarding Pneumocystis jirovecii infection in children under 3 years old. This retrospective cohort study aimed to describe medically relevant information among them. All children under 3 years old treated in the same medical units from April 2014 to August 2020 and in whom a P. jirovecii evaluation was undertaken were enrolled in the study. A positive case was defined as a child presenting at least one positive PCR for P. jirovecii in a respiratory sample. Medically relevant information such as demographical characteristics, clinical presentation, microbiological co-infections, and treatments were collected. The objectives were to describe the characteristics of these children with P. jirovecii colonization/infection to determine the key underlying diseases and risk factors, and to identify viral respiratory pathogens associated. The PCR was positive for P. jirovecii in 32 children. Cardiopulmonary pathologies (21.9%) were the most common underlying disease in them, followed by severe combined immunodeficiency (SCID) (18.8%), hyaline membrane disease (15.6%), asthma (9.4%) and acute leukaemia (6.3%). All SCID children were diagnosed with pneumocystis pneumonia. Co-infection with Pj/Rhinovirus (34.4%) was not significant. Overall mortality was 18.8%. Paediatric pneumocystis is not restricted to patients with HIV or SCID and should be considered in pneumonia in children under 3 years old.
format Online
Article
Text
id pubmed-8306698
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83066982021-07-25 Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age Menu, Estelle Driouich, Jean-Sélim Luciani, Léa Morand, Aurélie Ranque, Stéphane L’Ollivier, Coralie J Fungi (Basel) Article Few data are available in the literature regarding Pneumocystis jirovecii infection in children under 3 years old. This retrospective cohort study aimed to describe medically relevant information among them. All children under 3 years old treated in the same medical units from April 2014 to August 2020 and in whom a P. jirovecii evaluation was undertaken were enrolled in the study. A positive case was defined as a child presenting at least one positive PCR for P. jirovecii in a respiratory sample. Medically relevant information such as demographical characteristics, clinical presentation, microbiological co-infections, and treatments were collected. The objectives were to describe the characteristics of these children with P. jirovecii colonization/infection to determine the key underlying diseases and risk factors, and to identify viral respiratory pathogens associated. The PCR was positive for P. jirovecii in 32 children. Cardiopulmonary pathologies (21.9%) were the most common underlying disease in them, followed by severe combined immunodeficiency (SCID) (18.8%), hyaline membrane disease (15.6%), asthma (9.4%) and acute leukaemia (6.3%). All SCID children were diagnosed with pneumocystis pneumonia. Co-infection with Pj/Rhinovirus (34.4%) was not significant. Overall mortality was 18.8%. Paediatric pneumocystis is not restricted to patients with HIV or SCID and should be considered in pneumonia in children under 3 years old. MDPI 2021-07-09 /pmc/articles/PMC8306698/ /pubmed/34356925 http://dx.doi.org/10.3390/jof7070546 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Menu, Estelle
Driouich, Jean-Sélim
Luciani, Léa
Morand, Aurélie
Ranque, Stéphane
L’Ollivier, Coralie
Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age
title Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age
title_full Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age
title_fullStr Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age
title_full_unstemmed Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age
title_short Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age
title_sort detection of pneumocystis jirovecii in hospitalized children less than 3 years of age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306698/
https://www.ncbi.nlm.nih.gov/pubmed/34356925
http://dx.doi.org/10.3390/jof7070546
work_keys_str_mv AT menuestelle detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage
AT driouichjeanselim detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage
AT lucianilea detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage
AT morandaurelie detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage
AT ranquestephane detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage
AT lolliviercoralie detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage