Cargando…
Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age
Few data are available in the literature regarding Pneumocystis jirovecii infection in children under 3 years old. This retrospective cohort study aimed to describe medically relevant information among them. All children under 3 years old treated in the same medical units from April 2014 to August 2...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306698/ https://www.ncbi.nlm.nih.gov/pubmed/34356925 http://dx.doi.org/10.3390/jof7070546 |
_version_ | 1783727873292500992 |
---|---|
author | Menu, Estelle Driouich, Jean-Sélim Luciani, Léa Morand, Aurélie Ranque, Stéphane L’Ollivier, Coralie |
author_facet | Menu, Estelle Driouich, Jean-Sélim Luciani, Léa Morand, Aurélie Ranque, Stéphane L’Ollivier, Coralie |
author_sort | Menu, Estelle |
collection | PubMed |
description | Few data are available in the literature regarding Pneumocystis jirovecii infection in children under 3 years old. This retrospective cohort study aimed to describe medically relevant information among them. All children under 3 years old treated in the same medical units from April 2014 to August 2020 and in whom a P. jirovecii evaluation was undertaken were enrolled in the study. A positive case was defined as a child presenting at least one positive PCR for P. jirovecii in a respiratory sample. Medically relevant information such as demographical characteristics, clinical presentation, microbiological co-infections, and treatments were collected. The objectives were to describe the characteristics of these children with P. jirovecii colonization/infection to determine the key underlying diseases and risk factors, and to identify viral respiratory pathogens associated. The PCR was positive for P. jirovecii in 32 children. Cardiopulmonary pathologies (21.9%) were the most common underlying disease in them, followed by severe combined immunodeficiency (SCID) (18.8%), hyaline membrane disease (15.6%), asthma (9.4%) and acute leukaemia (6.3%). All SCID children were diagnosed with pneumocystis pneumonia. Co-infection with Pj/Rhinovirus (34.4%) was not significant. Overall mortality was 18.8%. Paediatric pneumocystis is not restricted to patients with HIV or SCID and should be considered in pneumonia in children under 3 years old. |
format | Online Article Text |
id | pubmed-8306698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83066982021-07-25 Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age Menu, Estelle Driouich, Jean-Sélim Luciani, Léa Morand, Aurélie Ranque, Stéphane L’Ollivier, Coralie J Fungi (Basel) Article Few data are available in the literature regarding Pneumocystis jirovecii infection in children under 3 years old. This retrospective cohort study aimed to describe medically relevant information among them. All children under 3 years old treated in the same medical units from April 2014 to August 2020 and in whom a P. jirovecii evaluation was undertaken were enrolled in the study. A positive case was defined as a child presenting at least one positive PCR for P. jirovecii in a respiratory sample. Medically relevant information such as demographical characteristics, clinical presentation, microbiological co-infections, and treatments were collected. The objectives were to describe the characteristics of these children with P. jirovecii colonization/infection to determine the key underlying diseases and risk factors, and to identify viral respiratory pathogens associated. The PCR was positive for P. jirovecii in 32 children. Cardiopulmonary pathologies (21.9%) were the most common underlying disease in them, followed by severe combined immunodeficiency (SCID) (18.8%), hyaline membrane disease (15.6%), asthma (9.4%) and acute leukaemia (6.3%). All SCID children were diagnosed with pneumocystis pneumonia. Co-infection with Pj/Rhinovirus (34.4%) was not significant. Overall mortality was 18.8%. Paediatric pneumocystis is not restricted to patients with HIV or SCID and should be considered in pneumonia in children under 3 years old. MDPI 2021-07-09 /pmc/articles/PMC8306698/ /pubmed/34356925 http://dx.doi.org/10.3390/jof7070546 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Menu, Estelle Driouich, Jean-Sélim Luciani, Léa Morand, Aurélie Ranque, Stéphane L’Ollivier, Coralie Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age |
title | Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age |
title_full | Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age |
title_fullStr | Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age |
title_full_unstemmed | Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age |
title_short | Detection of Pneumocystis jirovecii in Hospitalized Children Less Than 3 Years of Age |
title_sort | detection of pneumocystis jirovecii in hospitalized children less than 3 years of age |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306698/ https://www.ncbi.nlm.nih.gov/pubmed/34356925 http://dx.doi.org/10.3390/jof7070546 |
work_keys_str_mv | AT menuestelle detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage AT driouichjeanselim detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage AT lucianilea detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage AT morandaurelie detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage AT ranquestephane detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage AT lolliviercoralie detectionofpneumocystisjiroveciiinhospitalizedchildrenlessthan3yearsofage |