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Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins
Membrane proteins have evolved to work optimally within the complex environment of the biological membrane. Consequently, interactions with surrounding lipids are part of their molecular mechanism. Yet, the identification of lipid–protein interactions and the assessment of their molecular role is an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306737/ https://www.ncbi.nlm.nih.gov/pubmed/34298884 http://dx.doi.org/10.3390/ijms22147267 |
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author | Jodaitis, Léni van Oene, Thomas Martens, Chloé |
author_facet | Jodaitis, Léni van Oene, Thomas Martens, Chloé |
author_sort | Jodaitis, Léni |
collection | PubMed |
description | Membrane proteins have evolved to work optimally within the complex environment of the biological membrane. Consequently, interactions with surrounding lipids are part of their molecular mechanism. Yet, the identification of lipid–protein interactions and the assessment of their molecular role is an experimental challenge. Recently, biophysical approaches have emerged that are compatible with the study of membrane proteins in an environment closer to the biological membrane. These novel approaches revealed specific mechanisms of regulation of membrane protein function. Lipids have been shown to play a role in oligomerization, conformational transitions or allosteric coupling. In this review, we summarize the recent biophysical approaches, or combination thereof, that allow to decipher the role of lipid–protein interactions in the mechanism of membrane proteins. |
format | Online Article Text |
id | pubmed-8306737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83067372021-07-25 Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins Jodaitis, Léni van Oene, Thomas Martens, Chloé Int J Mol Sci Review Membrane proteins have evolved to work optimally within the complex environment of the biological membrane. Consequently, interactions with surrounding lipids are part of their molecular mechanism. Yet, the identification of lipid–protein interactions and the assessment of their molecular role is an experimental challenge. Recently, biophysical approaches have emerged that are compatible with the study of membrane proteins in an environment closer to the biological membrane. These novel approaches revealed specific mechanisms of regulation of membrane protein function. Lipids have been shown to play a role in oligomerization, conformational transitions or allosteric coupling. In this review, we summarize the recent biophysical approaches, or combination thereof, that allow to decipher the role of lipid–protein interactions in the mechanism of membrane proteins. MDPI 2021-07-06 /pmc/articles/PMC8306737/ /pubmed/34298884 http://dx.doi.org/10.3390/ijms22147267 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jodaitis, Léni van Oene, Thomas Martens, Chloé Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins |
title | Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins |
title_full | Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins |
title_fullStr | Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins |
title_full_unstemmed | Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins |
title_short | Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins |
title_sort | assessing the role of lipids in the molecular mechanism of membrane proteins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306737/ https://www.ncbi.nlm.nih.gov/pubmed/34298884 http://dx.doi.org/10.3390/ijms22147267 |
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