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Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins

Membrane proteins have evolved to work optimally within the complex environment of the biological membrane. Consequently, interactions with surrounding lipids are part of their molecular mechanism. Yet, the identification of lipid–protein interactions and the assessment of their molecular role is an...

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Detalles Bibliográficos
Autores principales: Jodaitis, Léni, van Oene, Thomas, Martens, Chloé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306737/
https://www.ncbi.nlm.nih.gov/pubmed/34298884
http://dx.doi.org/10.3390/ijms22147267
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author Jodaitis, Léni
van Oene, Thomas
Martens, Chloé
author_facet Jodaitis, Léni
van Oene, Thomas
Martens, Chloé
author_sort Jodaitis, Léni
collection PubMed
description Membrane proteins have evolved to work optimally within the complex environment of the biological membrane. Consequently, interactions with surrounding lipids are part of their molecular mechanism. Yet, the identification of lipid–protein interactions and the assessment of their molecular role is an experimental challenge. Recently, biophysical approaches have emerged that are compatible with the study of membrane proteins in an environment closer to the biological membrane. These novel approaches revealed specific mechanisms of regulation of membrane protein function. Lipids have been shown to play a role in oligomerization, conformational transitions or allosteric coupling. In this review, we summarize the recent biophysical approaches, or combination thereof, that allow to decipher the role of lipid–protein interactions in the mechanism of membrane proteins.
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spelling pubmed-83067372021-07-25 Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins Jodaitis, Léni van Oene, Thomas Martens, Chloé Int J Mol Sci Review Membrane proteins have evolved to work optimally within the complex environment of the biological membrane. Consequently, interactions with surrounding lipids are part of their molecular mechanism. Yet, the identification of lipid–protein interactions and the assessment of their molecular role is an experimental challenge. Recently, biophysical approaches have emerged that are compatible with the study of membrane proteins in an environment closer to the biological membrane. These novel approaches revealed specific mechanisms of regulation of membrane protein function. Lipids have been shown to play a role in oligomerization, conformational transitions or allosteric coupling. In this review, we summarize the recent biophysical approaches, or combination thereof, that allow to decipher the role of lipid–protein interactions in the mechanism of membrane proteins. MDPI 2021-07-06 /pmc/articles/PMC8306737/ /pubmed/34298884 http://dx.doi.org/10.3390/ijms22147267 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jodaitis, Léni
van Oene, Thomas
Martens, Chloé
Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins
title Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins
title_full Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins
title_fullStr Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins
title_full_unstemmed Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins
title_short Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins
title_sort assessing the role of lipids in the molecular mechanism of membrane proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306737/
https://www.ncbi.nlm.nih.gov/pubmed/34298884
http://dx.doi.org/10.3390/ijms22147267
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