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A Decade in Review after Idiopathic Scoliosis Was First Called a Complex Trait—A Tribute to the Late Dr. Yves Cotrel for His Support in Studies of Etiology of Scoliosis

Adolescent Idiopathic Scoliosis (AIS) is a prevalent and important spine disorder in the pediatric age group. An increased family tendency was observed for a long time, but the underlying genetic mechanism was uncertain. In 1999, Dr. Yves Cotrel founded the Cotrel Foundation in the Institut de Franc...

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Autores principales: Tang, Nelson L. S., Dobbs, Matthew B., Gurnett, Christina A., Qiu, Yong, Lam, T. P., Cheng, Jack C. Y., Hadley-Miller, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306836/
https://www.ncbi.nlm.nih.gov/pubmed/34356049
http://dx.doi.org/10.3390/genes12071033
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author Tang, Nelson L. S.
Dobbs, Matthew B.
Gurnett, Christina A.
Qiu, Yong
Lam, T. P.
Cheng, Jack C. Y.
Hadley-Miller, Nancy
author_facet Tang, Nelson L. S.
Dobbs, Matthew B.
Gurnett, Christina A.
Qiu, Yong
Lam, T. P.
Cheng, Jack C. Y.
Hadley-Miller, Nancy
author_sort Tang, Nelson L. S.
collection PubMed
description Adolescent Idiopathic Scoliosis (AIS) is a prevalent and important spine disorder in the pediatric age group. An increased family tendency was observed for a long time, but the underlying genetic mechanism was uncertain. In 1999, Dr. Yves Cotrel founded the Cotrel Foundation in the Institut de France, which supported collaboration of international researchers to work together to better understand the etiology of AIS. This new concept of AIS as a complex trait evolved in this setting among researchers who joined the annual Cotrel meetings. It is now over a decade since the first proposal of the complex trait genetic model for AIS. Here, we review in detail the vast information about the genetic and environmental factors in AIS pathogenesis gathered to date. More importantly, new insights into AIS etiology were brought to us through new research data under the perspective of a complex trait. Hopefully, future research directions may lead to better management of AIS, which has a tremendous impact on affected adolescents in terms of both physical growth and psychological development.
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spelling pubmed-83068362021-07-25 A Decade in Review after Idiopathic Scoliosis Was First Called a Complex Trait—A Tribute to the Late Dr. Yves Cotrel for His Support in Studies of Etiology of Scoliosis Tang, Nelson L. S. Dobbs, Matthew B. Gurnett, Christina A. Qiu, Yong Lam, T. P. Cheng, Jack C. Y. Hadley-Miller, Nancy Genes (Basel) Review Adolescent Idiopathic Scoliosis (AIS) is a prevalent and important spine disorder in the pediatric age group. An increased family tendency was observed for a long time, but the underlying genetic mechanism was uncertain. In 1999, Dr. Yves Cotrel founded the Cotrel Foundation in the Institut de France, which supported collaboration of international researchers to work together to better understand the etiology of AIS. This new concept of AIS as a complex trait evolved in this setting among researchers who joined the annual Cotrel meetings. It is now over a decade since the first proposal of the complex trait genetic model for AIS. Here, we review in detail the vast information about the genetic and environmental factors in AIS pathogenesis gathered to date. More importantly, new insights into AIS etiology were brought to us through new research data under the perspective of a complex trait. Hopefully, future research directions may lead to better management of AIS, which has a tremendous impact on affected adolescents in terms of both physical growth and psychological development. MDPI 2021-07-01 /pmc/articles/PMC8306836/ /pubmed/34356049 http://dx.doi.org/10.3390/genes12071033 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tang, Nelson L. S.
Dobbs, Matthew B.
Gurnett, Christina A.
Qiu, Yong
Lam, T. P.
Cheng, Jack C. Y.
Hadley-Miller, Nancy
A Decade in Review after Idiopathic Scoliosis Was First Called a Complex Trait—A Tribute to the Late Dr. Yves Cotrel for His Support in Studies of Etiology of Scoliosis
title A Decade in Review after Idiopathic Scoliosis Was First Called a Complex Trait—A Tribute to the Late Dr. Yves Cotrel for His Support in Studies of Etiology of Scoliosis
title_full A Decade in Review after Idiopathic Scoliosis Was First Called a Complex Trait—A Tribute to the Late Dr. Yves Cotrel for His Support in Studies of Etiology of Scoliosis
title_fullStr A Decade in Review after Idiopathic Scoliosis Was First Called a Complex Trait—A Tribute to the Late Dr. Yves Cotrel for His Support in Studies of Etiology of Scoliosis
title_full_unstemmed A Decade in Review after Idiopathic Scoliosis Was First Called a Complex Trait—A Tribute to the Late Dr. Yves Cotrel for His Support in Studies of Etiology of Scoliosis
title_short A Decade in Review after Idiopathic Scoliosis Was First Called a Complex Trait—A Tribute to the Late Dr. Yves Cotrel for His Support in Studies of Etiology of Scoliosis
title_sort decade in review after idiopathic scoliosis was first called a complex trait—a tribute to the late dr. yves cotrel for his support in studies of etiology of scoliosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306836/
https://www.ncbi.nlm.nih.gov/pubmed/34356049
http://dx.doi.org/10.3390/genes12071033
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