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Phytochemical Investigation, Antimicrobial, Antioxidant and Anticancer Activities of Acer cappadocicum Gled

The appearance of novel microbial resistance, diverse cancer ailment and several other morbidities such as appetite loss, hair loss, anemia, cell damage, etc., are among most critical situation that keeps the phytochemical quest on. Thus, this study characterized the antimicrobial, antioxidant, and...

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Autores principales: Kausar, Farzana, Farooqi, Muhammad-Awais, Farooqi, Hafiz-Muhammad-Umer, Salih, Abdul-Rahim-Chethikkattuveli, Khalil, Atif-Ali-Khan, Kang, Chul-woong, Mahmoud, Mohamed H., Batiha, Gaber-El-Saber, Choi, Kyung-hyun, Mumtaz, Abdul-Samad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306863/
https://www.ncbi.nlm.nih.gov/pubmed/34357028
http://dx.doi.org/10.3390/life11070656
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author Kausar, Farzana
Farooqi, Muhammad-Awais
Farooqi, Hafiz-Muhammad-Umer
Salih, Abdul-Rahim-Chethikkattuveli
Khalil, Atif-Ali-Khan
Kang, Chul-woong
Mahmoud, Mohamed H.
Batiha, Gaber-El-Saber
Choi, Kyung-hyun
Mumtaz, Abdul-Samad
author_facet Kausar, Farzana
Farooqi, Muhammad-Awais
Farooqi, Hafiz-Muhammad-Umer
Salih, Abdul-Rahim-Chethikkattuveli
Khalil, Atif-Ali-Khan
Kang, Chul-woong
Mahmoud, Mohamed H.
Batiha, Gaber-El-Saber
Choi, Kyung-hyun
Mumtaz, Abdul-Samad
author_sort Kausar, Farzana
collection PubMed
description The appearance of novel microbial resistance, diverse cancer ailment and several other morbidities such as appetite loss, hair loss, anemia, cell damage, etc., are among most critical situation that keeps the phytochemical quest on. Thus, this study characterized the antimicrobial, antioxidant, and anticancer potentials of a rarely accessed Acer cappadocicum gled (AC) population thriving in a remote Palas Valley in northern Pakistan. Leaf extracts of the plant were prepared in organic solvents with different polarities through maceration. Extracts were subjected to antimicrobial, antioxidant, and anticancer activities using agar well, DPPH and cell viability assays. A. cappadocicum methanolic extract (ACM) significantly inhibited bacterial growth, followed by n-butanolic extract (ACB) with the second-highest bacterial inhibition. Similar activity was observed against mycelial growth inhibition in plant-fungal pathogen by ACM and ACB. However, human pathogenic fungi did not affect much by extracts. In antioxidant assessment, the chloroform extract (ACC) showed strong scavenging activity and in cytotoxic evaluation, extracts restricted growth proliferation in cancer cells. The inhibitory evidence of extracts, potent scavenging ability, and low cell viability of human-derived cell lines supports the antimicrobial, antioxidant and anticancerous potential of A. cappadocicum. It advances our quest for natural product research.
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spelling pubmed-83068632021-07-25 Phytochemical Investigation, Antimicrobial, Antioxidant and Anticancer Activities of Acer cappadocicum Gled Kausar, Farzana Farooqi, Muhammad-Awais Farooqi, Hafiz-Muhammad-Umer Salih, Abdul-Rahim-Chethikkattuveli Khalil, Atif-Ali-Khan Kang, Chul-woong Mahmoud, Mohamed H. Batiha, Gaber-El-Saber Choi, Kyung-hyun Mumtaz, Abdul-Samad Life (Basel) Article The appearance of novel microbial resistance, diverse cancer ailment and several other morbidities such as appetite loss, hair loss, anemia, cell damage, etc., are among most critical situation that keeps the phytochemical quest on. Thus, this study characterized the antimicrobial, antioxidant, and anticancer potentials of a rarely accessed Acer cappadocicum gled (AC) population thriving in a remote Palas Valley in northern Pakistan. Leaf extracts of the plant were prepared in organic solvents with different polarities through maceration. Extracts were subjected to antimicrobial, antioxidant, and anticancer activities using agar well, DPPH and cell viability assays. A. cappadocicum methanolic extract (ACM) significantly inhibited bacterial growth, followed by n-butanolic extract (ACB) with the second-highest bacterial inhibition. Similar activity was observed against mycelial growth inhibition in plant-fungal pathogen by ACM and ACB. However, human pathogenic fungi did not affect much by extracts. In antioxidant assessment, the chloroform extract (ACC) showed strong scavenging activity and in cytotoxic evaluation, extracts restricted growth proliferation in cancer cells. The inhibitory evidence of extracts, potent scavenging ability, and low cell viability of human-derived cell lines supports the antimicrobial, antioxidant and anticancerous potential of A. cappadocicum. It advances our quest for natural product research. MDPI 2021-07-05 /pmc/articles/PMC8306863/ /pubmed/34357028 http://dx.doi.org/10.3390/life11070656 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kausar, Farzana
Farooqi, Muhammad-Awais
Farooqi, Hafiz-Muhammad-Umer
Salih, Abdul-Rahim-Chethikkattuveli
Khalil, Atif-Ali-Khan
Kang, Chul-woong
Mahmoud, Mohamed H.
Batiha, Gaber-El-Saber
Choi, Kyung-hyun
Mumtaz, Abdul-Samad
Phytochemical Investigation, Antimicrobial, Antioxidant and Anticancer Activities of Acer cappadocicum Gled
title Phytochemical Investigation, Antimicrobial, Antioxidant and Anticancer Activities of Acer cappadocicum Gled
title_full Phytochemical Investigation, Antimicrobial, Antioxidant and Anticancer Activities of Acer cappadocicum Gled
title_fullStr Phytochemical Investigation, Antimicrobial, Antioxidant and Anticancer Activities of Acer cappadocicum Gled
title_full_unstemmed Phytochemical Investigation, Antimicrobial, Antioxidant and Anticancer Activities of Acer cappadocicum Gled
title_short Phytochemical Investigation, Antimicrobial, Antioxidant and Anticancer Activities of Acer cappadocicum Gled
title_sort phytochemical investigation, antimicrobial, antioxidant and anticancer activities of acer cappadocicum gled
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306863/
https://www.ncbi.nlm.nih.gov/pubmed/34357028
http://dx.doi.org/10.3390/life11070656
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