PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair

SIMPLE SUMMARY: DNA-damaging chemotherapeutics, such as platinum drugs, are cornerstones in cancer treatment. The efficacy of such treatment is intimately linked to the DNA repair capacity of the cancer cells, as DNA damage above a tolerable threshold culminates in cell death. Cancer cells often hav...

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Detalles Bibliográficos
Autores principales: Ninou, Anna Huguet, Lehto, Jemina, Chioureas, Dimitrios, Stigsdotter, Hannah, Schelzig, Korbinian, Åkerlund, Emma, Gudoityte, Greta, Joneborg, Ulrika, Carlson, Joseph, Jonkers, Jos, Seashore-Ludlow, Brinton, Gustafsson, Nina Marie Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306909/
https://www.ncbi.nlm.nih.gov/pubmed/34298817
http://dx.doi.org/10.3390/cancers13143604

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