Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis

Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colo...

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Autores principales: Khan, Umama, Chowdhury, Sabrina, Billah, Md Morsaline, Islam, Kazi Mohammed Didarul, Thorlacius, Henrik, Rahman, Milladur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307027/
https://www.ncbi.nlm.nih.gov/pubmed/34298878
http://dx.doi.org/10.3390/ijms22147260
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author Khan, Umama
Chowdhury, Sabrina
Billah, Md Morsaline
Islam, Kazi Mohammed Didarul
Thorlacius, Henrik
Rahman, Milladur
author_facet Khan, Umama
Chowdhury, Sabrina
Billah, Md Morsaline
Islam, Kazi Mohammed Didarul
Thorlacius, Henrik
Rahman, Milladur
author_sort Khan, Umama
collection PubMed
description Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to highlight roles of NETs in CRC progression and metastasis as well as the potential of targeting NETs during colon cancer therapy.
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spelling pubmed-83070272021-07-25 Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis Khan, Umama Chowdhury, Sabrina Billah, Md Morsaline Islam, Kazi Mohammed Didarul Thorlacius, Henrik Rahman, Milladur Int J Mol Sci Review Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to highlight roles of NETs in CRC progression and metastasis as well as the potential of targeting NETs during colon cancer therapy. MDPI 2021-07-06 /pmc/articles/PMC8307027/ /pubmed/34298878 http://dx.doi.org/10.3390/ijms22147260 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khan, Umama
Chowdhury, Sabrina
Billah, Md Morsaline
Islam, Kazi Mohammed Didarul
Thorlacius, Henrik
Rahman, Milladur
Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis
title Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis
title_full Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis
title_fullStr Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis
title_full_unstemmed Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis
title_short Neutrophil Extracellular Traps in Colorectal Cancer Progression and Metastasis
title_sort neutrophil extracellular traps in colorectal cancer progression and metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307027/
https://www.ncbi.nlm.nih.gov/pubmed/34298878
http://dx.doi.org/10.3390/ijms22147260
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AT islamkazimohammeddidarul neutrophilextracellulartrapsincolorectalcancerprogressionandmetastasis
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