Cargando…

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Oxyresveratrol has recently attracted much research attention due to its simple chemical structure and diverse therapeutic potentials. Previous reviews describe the chemistry and biological activities of this phytoalexin, but additional coverage and greater accessibility are still needed. The curren...

Descripción completa

Detalles Bibliográficos
Autor principal: Likhitwitayawuid, Kittisak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307110/
https://www.ncbi.nlm.nih.gov/pubmed/34299485
http://dx.doi.org/10.3390/molecules26144212
_version_ 1783727971965599744
author Likhitwitayawuid, Kittisak
author_facet Likhitwitayawuid, Kittisak
author_sort Likhitwitayawuid, Kittisak
collection PubMed
description Oxyresveratrol has recently attracted much research attention due to its simple chemical structure and diverse therapeutic potentials. Previous reviews describe the chemistry and biological activities of this phytoalexin, but additional coverage and greater accessibility are still needed. The current review provides a more comprehensive summary, covering research from 1955 to the present year. Oxyresveratrol occurs in both gymnosperms and angiosperms. However, it has never been reported in plants in the subclass Sympetalae, and this point might be of both chemotaxonomic and biosynthetic importance. Oxyresveratrol can be easily obtained from plant materials by conventional methods, and several systems for both qualitative and quantitative analysis of oxyresveratrol contents in plant materials and plant products are available. Oxyresveratrol possesses diverse biological and pharmacological activities such as the inhibition of tyrosinase and melanogenesis, antioxidant and anti-inflammatory activities, and protective effects against neurological disorders and digestive ailments. However, the unfavorable pharmacokinetic properties of oxyresveratrol, including low water solubility and poor oral availability and stability, have posed challenges to its development as a useful therapeutic agent. Recently, several delivery systems have emerged, with promising outcomes that may improve chances for the clinical study of oxyresveratrol.
format Online
Article
Text
id pubmed-8307110
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83071102021-07-25 Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems Likhitwitayawuid, Kittisak Molecules Review Oxyresveratrol has recently attracted much research attention due to its simple chemical structure and diverse therapeutic potentials. Previous reviews describe the chemistry and biological activities of this phytoalexin, but additional coverage and greater accessibility are still needed. The current review provides a more comprehensive summary, covering research from 1955 to the present year. Oxyresveratrol occurs in both gymnosperms and angiosperms. However, it has never been reported in plants in the subclass Sympetalae, and this point might be of both chemotaxonomic and biosynthetic importance. Oxyresveratrol can be easily obtained from plant materials by conventional methods, and several systems for both qualitative and quantitative analysis of oxyresveratrol contents in plant materials and plant products are available. Oxyresveratrol possesses diverse biological and pharmacological activities such as the inhibition of tyrosinase and melanogenesis, antioxidant and anti-inflammatory activities, and protective effects against neurological disorders and digestive ailments. However, the unfavorable pharmacokinetic properties of oxyresveratrol, including low water solubility and poor oral availability and stability, have posed challenges to its development as a useful therapeutic agent. Recently, several delivery systems have emerged, with promising outcomes that may improve chances for the clinical study of oxyresveratrol. MDPI 2021-07-11 /pmc/articles/PMC8307110/ /pubmed/34299485 http://dx.doi.org/10.3390/molecules26144212 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Likhitwitayawuid, Kittisak
Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems
title Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems
title_full Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems
title_fullStr Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems
title_full_unstemmed Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems
title_short Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems
title_sort oxyresveratrol: sources, productions, biological activities, pharmacokinetics, and delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307110/
https://www.ncbi.nlm.nih.gov/pubmed/34299485
http://dx.doi.org/10.3390/molecules26144212
work_keys_str_mv AT likhitwitayawuidkittisak oxyresveratrolsourcesproductionsbiologicalactivitiespharmacokineticsanddeliverysystems