Total Synthesis of Pagoamide A

The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous structural confirmation of pagoamide A.

Detalles Bibliográficos
Autores principales: Wu, Fusong, Yu, Jie, Meng, Jiawei, Guo, Yian, Ye, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307129/
https://www.ncbi.nlm.nih.gov/pubmed/34299497
http://dx.doi.org/10.3390/molecules26144224
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author Wu, Fusong
Yu, Jie
Meng, Jiawei
Guo, Yian
Ye, Tao
author_facet Wu, Fusong
Yu, Jie
Meng, Jiawei
Guo, Yian
Ye, Tao
author_sort Wu, Fusong
collection PubMed
description The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous structural confirmation of pagoamide A.
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spelling pubmed-83071292021-07-25 Total Synthesis of Pagoamide A Wu, Fusong Yu, Jie Meng, Jiawei Guo, Yian Ye, Tao Molecules Article The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous structural confirmation of pagoamide A. MDPI 2021-07-12 /pmc/articles/PMC8307129/ /pubmed/34299497 http://dx.doi.org/10.3390/molecules26144224 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Fusong
Yu, Jie
Meng, Jiawei
Guo, Yian
Ye, Tao
Total Synthesis of Pagoamide A
title Total Synthesis of Pagoamide A
title_full Total Synthesis of Pagoamide A
title_fullStr Total Synthesis of Pagoamide A
title_full_unstemmed Total Synthesis of Pagoamide A
title_short Total Synthesis of Pagoamide A
title_sort total synthesis of pagoamide a
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307129/
https://www.ncbi.nlm.nih.gov/pubmed/34299497
http://dx.doi.org/10.3390/molecules26144224
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