Cargando…

Posttranscriptional Regulation of the Human ABCG2 Multidrug Transporter Protein by Artificial Mirtrons

ABCG2 is a membrane transporter protein that has been associated with multidrug resistance phenotype and tumor development. Additionally, it is expressed in various stem cells, providing cellular protection against endobiotics and xenobiotics. In this study, we designed artificial mirtrons to regula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schamberger, Anita, Várady, György, Fóthi, Ábel, Orbán, Tamás I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307164/ https://www.ncbi.nlm.nih.gov/pubmed/34356084 http://dx.doi.org/10.3390/genes12071068

Ejemplares similares

Generation of multidrug resistant human tissues by overexpression of the ABCG2 multidrug transporter in embryonic stem cells
por: Erdei, Zsuzsa, et al.
Publicado: (2018)

Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter
por: Zámbó, Boglárka, et al.
Publicado: (2019)

Comparing miRNA structure of mirtrons and non-mirtrons
por: Titov, Igor I., et al.
Publicado: (2018)

mirtronDB: a mirtron knowledge base
por: Da Fonseca, Bruno Henrique Ribeiro, et al.
Publicado: (2019)

Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop
por: Mózner, Orsolya, et al.
Publicado: (2023)

A new fluorescent dye accumulation assay for parallel measurements of the ABCG2, ABCB1 and ABCC1 multidrug transporter functions
por: Szabó, Edit, et al.
Publicado: (2018)

Expression Levels of the ABCG2 Multidrug Transporter in Human Erythrocytes Correspond to Pharmacologically Relevant Genetic Variations
por: Kasza, Ildikó, et al.
Publicado: (2012)

Nucleotide binding is the critical regulator of ABCG2 conformational transitions
por: Gyöngy, Zsuzsanna, et al.
Publicado: (2023)

Knockdown and replacement therapy mediated by artificial mirtrons in spinocerebellar ataxia 7
por: Curtis, Helen J., et al.
Publicado: (2017)

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression
por: Zámbó, Boglárka, et al.
Publicado: (2018)

Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224
por: Sibley, Christopher R., et al.
Publicado: (2012)

Large-Scale Identification of Mirtrons in Arabidopsis and Rice
por: Meng, Yijun, et al.
Publicado: (2012)

Poziotinib Inhibits the Efflux Activity of the ABCB1 and ABCG2 Transporters and the Expression of the ABCG2 Transporter Protein in Multidrug Resistant Colon Cancer Cells
por: Zhang, Yongchao, et al.
Publicado: (2020)

Jump into a New Fold—A Homology Based Model for the ABCG2/BCRP Multidrug Transporter
por: László, Laura, et al.
Publicado: (2016)

The transport pathway in the ABCG2 protein and its regulation revealed by molecular dynamics simulations
por: Nagy, Tamás, et al.
Publicado: (2020)

The biogenesis and characterization of mammalian microRNAs of mirtron origin
por: Sibley, Christopher R., et al.
Publicado: (2012)

Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene
por: Reé, Dóra, et al.
Publicado: (2022)

The multidrug transporter ABCG2: still more questions than answers
por: Horsey, Aaron J., et al.
Publicado: (2016)

Functional VEGFA knockdown with artificial 3′-tailed mirtrons defined by 5′ splice site and branch point
por: Kock, Kian Hong, et al.
Publicado: (2015)

Discovery of hundreds of mirtrons in mouse and human small RNA data
por: Ladewig, Erik, et al.
Publicado: (2012)

Genetic polymorphisms and decreased protein expression of ABCG2 urate transporters are associated with susceptibility to gout, disease severity and renal-overload hyperuricemia
por: Pálinkás, Márton, et al.
Publicado: (2022)

The Reentry Helix Is Potentially Involved in Cholesterol Sensing of the ABCG1 Transporter Protein
por: Hegyi, Zoltán, et al.
Publicado: (2022)

The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid
por: Khunweeraphong, Narakorn, et al.
Publicado: (2019)

Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2
por: Rasouli, Ali, et al.
Publicado: (2022)

ABCG5 and ABCG8 Are Involved in Vitamin K Transport
por: Matsuo, Michinori, et al.
Publicado: (2023)

Widespread posttranscriptional regulation of cotransmission
por: Chen, Nannan, et al.
Publicado: (2023)

Mirtron-mediated RNA knockdown/replacement therapy for the treatment of dominant retinitis pigmentosa
por: Orlans, Harry O., et al.
Publicado: (2021)

Posttranscriptional Regulation and RNA Binding Proteins in Cancer Biology
por: Ghigna, Claudia, et al.
Publicado: (2015)

Posttranscriptional regulation of neurofilament proteins and tau in health and disease
por: Yuan, Aidong, et al.
Publicado: (2023)

The first intracellular loop is essential for the catalytic cycle of the human ABCG2 multidrug resistance transporter
por: Khunweeraphong, Narakorn, et al.
Publicado: (2020)

Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers
por: Kolacsek, Orsolya, et al.
Publicado: (2011)

Correction: Reliable transgene-independent method for determining sleeping beauty transposon copy numbers
por: Kolacsek, Orsolya, et al.
Publicado: (2013)

3′ IsomiR Species and DNA Contamination Influence Reliable Quantification of MicroRNAs by Stem-Loop Quantitative PCR
por: Schamberger, Anita, et al.
Publicado: (2014)

Analysis of Nearly One Thousand Mammalian Mirtrons Reveals Novel Features of Dicer Substrates
por: Wen, Jiayu, et al.
Publicado: (2015)

Distinguishing mirtrons from canonical miRNAs with data exploration and machine learning methods
por: Rorbach, Grzegorz, et al.
Publicado: (2018)

MET inhibitor tepotinib antagonizes multidrug resistance mediated by ABCG2 transporter: In vitro and in vivo study
por: Wu, Zhuo-Xun, et al.
Publicado: (2022)

Imperatorin Restores Chemosensitivity of Multidrug-Resistant Cancer Cells by Antagonizing ABCG2-Mediated Drug Transport
por: Wu, Chung-Pu, et al.
Publicado: (2023)

Regulation of Vascular Function on Posttranscriptional Level
por: Eisenreich, Andreas
Publicado: (2013)

Dynamic RNA Modifications in Posttranscriptional Regulation
por: Wang, Xiao, et al.
Publicado: (2014)

TIS11 Family Proteins and Their Roles in Posttranscriptional Gene Regulation
por: Baou, Maria, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_cpc4t7ef22o86k3vrtv1sbtk89