Cargando…

Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells

Recently, natural compounds have been used globally for cancer treatment studies. Silibinin is a natural compound extracted from Silybum marianum (milk thistle), which has been suggested as an anticancer drug through various studies. Studies on its activity in various cancers are undergoing. This st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rugamba, Alexis, Kang, Dong Young, Sp, Nipin, Jo, Eun Seong, Lee, Jin-Moo, Bae, Se Won, Jang, Kyoung-Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307196/ https://www.ncbi.nlm.nih.gov/pubmed/34209829 http://dx.doi.org/10.3390/cells10071632

Ejemplares similares

The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells
por: Kang, Dong Young, et al.
Publicado: (2020)

Mechanistic Insights of Anti-Immune Evasion by Nobiletin through Regulating miR-197/STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer (NSCLC) Cells
por: Sp, Nipin, et al.
Publicado: (2021)

Pivotal Role of Iron Homeostasis in the Induction of Mitochondrial Apoptosis by 6-Gingerol Through PTEN Regulated PD-L1 Expression in Embryonic Cancer Cells
por: Sp, Nipin, et al.
Publicado: (2021)

Natural Sulfurs Inhibit LPS-Induced Inflammatory Responses through NF-κB Signaling in CCD-986Sk Skin Fibroblasts
por: Sp, Nipin, et al.
Publicado: (2021)

Sulfur Compounds Inhibit High Glucose-Induced Inflammation by Regulating NF-κB Signaling in Human Monocytes
por: Jo, Eun Seong, et al.
Publicado: (2020)

Potential Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells
por: Sp, Nipin, et al.
Publicado: (2021)

Antitumor Effects of Ursolic Acid through Mediating the Inhibition of STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer Cells
por: Kang, Dong Young, et al.
Publicado: (2021)

Non-toxic sulfur inhibits LPS-induced inflammation by regulating TLR-4 and JAK2/STAT3 through IL-6 signaling
por: Kang, Dong Young, et al.
Publicado: (2021)

Iron Metabolism as a Potential Mechanism for Inducing TRAIL-Mediated Extrinsic Apoptosis Using Methylsulfonylmethane in Embryonic Cancer Stem Cells
por: Sp, Nipin, et al.
Publicado: (2021)

Antitumor Effects of Natural Bioactive Ursolic Acid in Embryonic Cancer Stem Cells
por: Kang, Dong Young, et al.
Publicado: (2022)

Tannic Acid Promotes TRAIL-Induced Extrinsic Apoptosis by Regulating Mitochondrial ROS in Human Embryonic Carcinoma Cells
por: Sp, Nipin, et al.
Publicado: (2020)

New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NF-κB Signaling-Mediated Inflammatory Responses in Human Monocytes
por: Kang, Dong Young, et al.
Publicado: (2021)

Success of tumorsphere isolation from WHO grade IV gliomas does not correlate with the weight of fresh tumor specimens: an immunohistochemical characterization of tumorsphere differentiation
por: Sung, Kyoung Su, et al.
Publicado: (2016)

A lignan from Alnus japonica inhibits glioblastoma tumorspheres by suppression of FOXM1
por: Shim, Jin-Kyoung, et al.
Publicado: (2022)

Silibinin Inhibits NSCLC Metastasis by Targeting the EGFR/LOX Pathway
por: Hou, Xiaoying, et al.
Publicado: (2018)

Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres
por: Yoon, Seon-Jin, et al.
Publicado: (2020)

Combined effects of niclosamide and temozolomide against human glioblastoma tumorspheres
por: Oh, Hyeong-Cheol, et al.
Publicado: (2020)

The Skin-Whitening and Antioxidant Effects of Protocatechuic Acid (PCA) Derivatives in Melanoma and Fibroblast Cell Lines
por: Cho, Jaehoon, et al.
Publicado: (2023)

Tumorspheres but Not Adherent Cells Derived from Retinoblastoma Tumors Are of Malignant Origin
por: Bond, Wesley S., et al.
Publicado: (2013)

SOX2OT lncRNA Inhibition Suppresses the Stemness Characteristics of Esophageal Tumorspheres
por: Haghi, Boshra, et al.
Publicado: (2022)

Understanding the influence of substrate when growing tumorspheres
por: Benítez, Lucía, et al.
Publicado: (2021)

Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells
por: Gwynne, William D., et al.
Publicado: (2019)

Adipose-derived mesenchymal stem cells exhibit tumor tropism and promote tumorsphere formation of breast cancer cells
por: Chen, Yanqing, et al.
Publicado: (2019)

Tumorsphere as an effective in vitro platform for screening anti-cancer stem cell drugs
por: Lee, Che-Hsin, et al.
Publicado: (2015)

Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program
por: Park, Junseong, et al.
Publicado: (2023)

Silibinin Suppresses TNF-α-Induced MMP-9 Expression in Gastric Cancer Cells through Inhibition of the MAPK Pathway
por: Kim, Sangmin, et al.
Publicado: (2009)

The Culture of Cancer Cell Lines as Tumorspheres Does Not Systematically Result in Cancer Stem Cell Enrichment
por: Calvet, Christophe Y., et al.
Publicado: (2014)

Silibinin Suppresses the Hyperlipidemic Effects of the ALK-Tyrosine Kinase Inhibitor Lorlatinib in Hepatic Cells
por: Verdura, Sara, et al.
Publicado: (2022)

Anticancer effect of silibinin on the xenograft model using MDA-MB-468 breast cancer cells
por: Kil, Won Ho, et al.
Publicado: (2014)

Inhibition of Phagocytosis by Silibinin in Mouse Macrophages
por: Sun, Kyung-Hoon, et al.
Publicado: (2023)

Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model
por: Yakisich, Juan Sebastian, et al.
Publicado: (2016)

Silibinin Attenuates Silica Dioxide Nanoparticles-Induced Inflammation by Suppressing TXNIP/MAPKs/AP-1 Signaling
por: Lim, Je-Oh, et al.
Publicado: (2020)

Inhibitory Effects of Peptide Lunasin in Colorectal Cancer HCT-116 Cells and Their Tumorsphere-Derived Subpopulation
por: Fernández-Tomé, Samuel, et al.
Publicado: (2020)

MDSC subtypes and CD39 expression on CD8(+) T cells predict the efficacy of anti‐PD‐1 immunotherapy in patients with advanced NSCLC
por: Koh, Jiae, et al.
Publicado: (2020)

Response of Estrogen Receptor-Positive Breast Cancer Tumorspheres to Antiestrogen Treatments
por: Ao, Ada, et al.
Publicado: (2011)

Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)
por: Choi, Junjeong, et al.
Publicado: (2016)

Combinatorial Therapeutic Effect of Inhibitors of Aldehyde Dehydrogenase and Mitochondrial Complex I, and the Chemotherapeutic Drug, Temozolomide against Glioblastoma Tumorspheres
por: Park, Hun Ho, et al.
Publicado: (2021)

A high ATP concentration enhances the cooperative translocation of the SARS coronavirus helicase nsP13 in the unwinding of duplex RNA
por: Jang, Kyoung-Jin, et al.
Publicado: (2020)

RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells
por: Brusgard, Jessica L., et al.
Publicado: (2015)

Effect of CD44 Binding Peptide Conjugated to an Engineered Inert Matrix on Maintenance of Breast Cancer Stem Cells and Tumorsphere Formation
por: Yang, Xiaoming, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_l76ufhjmismda7cs1kaat0vj8a