Cargando…

Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model

This study evaluated the biocompatibility and biological performance of novel additive-manufactured bioabsorbable iron-based porous suture anchors (iron_SAs). Two types of bioabsorbable iron_SAs, with double- and triple-helical structures (iron_SA_2_helix and iron_SA_3_helix, respectively), were com...

Descripción completa

Detalles Bibliográficos
Autores principales: Tai, Chien-Cheng, Lo, Hon-Lok, Liaw, Chen-Kun, Huang, Yu-Min, Huang, Yen-Hua, Yang, Kuo-Yi, Huang, Chih-Chieh, Huang, Shin-I, Shen, Hsin-Hsin, Lin, Tzu-Hung, Lu, Chun-Kuan, Liu, Wen-Chih, Sun, Jui-Sheng, Tsai, Pei-I, Chen, Chih-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307211/
https://www.ncbi.nlm.nih.gov/pubmed/34298988
http://dx.doi.org/10.3390/ijms22147368
_version_ 1783727996286271488
author Tai, Chien-Cheng
Lo, Hon-Lok
Liaw, Chen-Kun
Huang, Yu-Min
Huang, Yen-Hua
Yang, Kuo-Yi
Huang, Chih-Chieh
Huang, Shin-I
Shen, Hsin-Hsin
Lin, Tzu-Hung
Lu, Chun-Kuan
Liu, Wen-Chih
Sun, Jui-Sheng
Tsai, Pei-I
Chen, Chih-Yu
author_facet Tai, Chien-Cheng
Lo, Hon-Lok
Liaw, Chen-Kun
Huang, Yu-Min
Huang, Yen-Hua
Yang, Kuo-Yi
Huang, Chih-Chieh
Huang, Shin-I
Shen, Hsin-Hsin
Lin, Tzu-Hung
Lu, Chun-Kuan
Liu, Wen-Chih
Sun, Jui-Sheng
Tsai, Pei-I
Chen, Chih-Yu
author_sort Tai, Chien-Cheng
collection PubMed
description This study evaluated the biocompatibility and biological performance of novel additive-manufactured bioabsorbable iron-based porous suture anchors (iron_SAs). Two types of bioabsorbable iron_SAs, with double- and triple-helical structures (iron_SA_2_helix and iron_SA_3_helix, respectively), were compared with the synthetic polymer-based bioabsorbable suture anchor (polymer_SAs). An in vitro mechanical test, MTT assay, and scanning electron microscope (SEM) analysis were performed. An in vivo animal study was also performed. The three types of suture anchors were randomly implanted in the outer cortex of the lateral femoral condyle. The ultimate in vitro pullout strength of the iron_SA_3_helix group was significantly higher than the iron_SA_2_helix and polymer_SA groups. The MTT assay findings demonstrated no significant cytotoxicity, and the SEM analysis showed cells attachment on implant surface. The ultimate failure load of the iron_SA_3_helix group was significantly higher than that of the polymer_SA group. The micro-CT analysis indicated the iron_SA_3_helix group showed a higher bone volume fraction (BV/TV) after surgery. Moreover, both iron SAs underwent degradation with time. Iron_SAs with triple-helical threads and a porous structure demonstrated better mechanical strength and high biocompatibility after short-term implantation. The combined advantages of the mechanical superiority of the iron metal and the possibility of absorption after implantation make the iron_SA a suitable candidate for further development.
format Online
Article
Text
id pubmed-8307211
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83072112021-07-25 Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model Tai, Chien-Cheng Lo, Hon-Lok Liaw, Chen-Kun Huang, Yu-Min Huang, Yen-Hua Yang, Kuo-Yi Huang, Chih-Chieh Huang, Shin-I Shen, Hsin-Hsin Lin, Tzu-Hung Lu, Chun-Kuan Liu, Wen-Chih Sun, Jui-Sheng Tsai, Pei-I Chen, Chih-Yu Int J Mol Sci Article This study evaluated the biocompatibility and biological performance of novel additive-manufactured bioabsorbable iron-based porous suture anchors (iron_SAs). Two types of bioabsorbable iron_SAs, with double- and triple-helical structures (iron_SA_2_helix and iron_SA_3_helix, respectively), were compared with the synthetic polymer-based bioabsorbable suture anchor (polymer_SAs). An in vitro mechanical test, MTT assay, and scanning electron microscope (SEM) analysis were performed. An in vivo animal study was also performed. The three types of suture anchors were randomly implanted in the outer cortex of the lateral femoral condyle. The ultimate in vitro pullout strength of the iron_SA_3_helix group was significantly higher than the iron_SA_2_helix and polymer_SA groups. The MTT assay findings demonstrated no significant cytotoxicity, and the SEM analysis showed cells attachment on implant surface. The ultimate failure load of the iron_SA_3_helix group was significantly higher than that of the polymer_SA group. The micro-CT analysis indicated the iron_SA_3_helix group showed a higher bone volume fraction (BV/TV) after surgery. Moreover, both iron SAs underwent degradation with time. Iron_SAs with triple-helical threads and a porous structure demonstrated better mechanical strength and high biocompatibility after short-term implantation. The combined advantages of the mechanical superiority of the iron metal and the possibility of absorption after implantation make the iron_SA a suitable candidate for further development. MDPI 2021-07-08 /pmc/articles/PMC8307211/ /pubmed/34298988 http://dx.doi.org/10.3390/ijms22147368 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tai, Chien-Cheng
Lo, Hon-Lok
Liaw, Chen-Kun
Huang, Yu-Min
Huang, Yen-Hua
Yang, Kuo-Yi
Huang, Chih-Chieh
Huang, Shin-I
Shen, Hsin-Hsin
Lin, Tzu-Hung
Lu, Chun-Kuan
Liu, Wen-Chih
Sun, Jui-Sheng
Tsai, Pei-I
Chen, Chih-Yu
Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model
title Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model
title_full Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model
title_fullStr Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model
title_full_unstemmed Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model
title_short Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model
title_sort biocompatibility and biological performance evaluation of additive-manufactured bioabsorbable iron-based porous suture anchor in a rabbit model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307211/
https://www.ncbi.nlm.nih.gov/pubmed/34298988
http://dx.doi.org/10.3390/ijms22147368
work_keys_str_mv AT taichiencheng biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT lohonlok biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT liawchenkun biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT huangyumin biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT huangyenhua biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT yangkuoyi biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT huangchihchieh biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT huangshini biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT shenhsinhsin biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT lintzuhung biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT luchunkuan biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT liuwenchih biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT sunjuisheng biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT tsaipeii biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel
AT chenchihyu biocompatibilityandbiologicalperformanceevaluationofadditivemanufacturedbioabsorbableironbasedporoussutureanchorinarabbitmodel