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Bioaccessibility and Bioactivity of Cereal Polyphenols: A Review

Cereal bioactive compounds, especially polyphenols, are known to possess a wide range of disease preventive properties that are attributed to their antioxidant and anti-inflammatory activity. However, due to their low plasma concentrations after oral intake, there is controversy regarding their ther...

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Autores principales: Ed Nignpense, Borkwei, Francis, Nidhish, Blanchard, Christopher, Santhakumar, Abishek Bommannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307242/
https://www.ncbi.nlm.nih.gov/pubmed/34359469
http://dx.doi.org/10.3390/foods10071595
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author Ed Nignpense, Borkwei
Francis, Nidhish
Blanchard, Christopher
Santhakumar, Abishek Bommannan
author_facet Ed Nignpense, Borkwei
Francis, Nidhish
Blanchard, Christopher
Santhakumar, Abishek Bommannan
author_sort Ed Nignpense, Borkwei
collection PubMed
description Cereal bioactive compounds, especially polyphenols, are known to possess a wide range of disease preventive properties that are attributed to their antioxidant and anti-inflammatory activity. However, due to their low plasma concentrations after oral intake, there is controversy regarding their therapeutic benefits in vivo. Within the gastrointestinal tract, some cereal polyphenols are absorbed in the small intestine, with the majority accumulating and metabolised by the colonic microbiota. Chemical and enzymatic processes occurring during gastrointestinal digestion modulate the bioactivity and bioaccessibility of phenolic compounds. The interactions between the cereal polyphenols and the intestinal epithelium allow the modulation of intestinal barrier function through antioxidant, anti-inflammatory activity and mucin production thereby improving intestinal health. The intestinal microbiota is believed to have a reciprocal interaction with polyphenols, wherein the microbiome produces bioactive and bioaccessible phenolic metabolites and the phenolic compound, in turn, modifies the microbiome composition favourably. Thus, the microbiome presents a key link between polyphenol consumption and the health benefits observed in metabolic conditions in numerous studies. This review will explore the therapeutic value of cereal polyphenols in conjunction with their bioaccessibility, impact on intestinal barrier function and interaction with the microbiome coupled with plasma anti-inflammatory effects.
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spelling pubmed-83072422021-07-25 Bioaccessibility and Bioactivity of Cereal Polyphenols: A Review Ed Nignpense, Borkwei Francis, Nidhish Blanchard, Christopher Santhakumar, Abishek Bommannan Foods Review Cereal bioactive compounds, especially polyphenols, are known to possess a wide range of disease preventive properties that are attributed to their antioxidant and anti-inflammatory activity. However, due to their low plasma concentrations after oral intake, there is controversy regarding their therapeutic benefits in vivo. Within the gastrointestinal tract, some cereal polyphenols are absorbed in the small intestine, with the majority accumulating and metabolised by the colonic microbiota. Chemical and enzymatic processes occurring during gastrointestinal digestion modulate the bioactivity and bioaccessibility of phenolic compounds. The interactions between the cereal polyphenols and the intestinal epithelium allow the modulation of intestinal barrier function through antioxidant, anti-inflammatory activity and mucin production thereby improving intestinal health. The intestinal microbiota is believed to have a reciprocal interaction with polyphenols, wherein the microbiome produces bioactive and bioaccessible phenolic metabolites and the phenolic compound, in turn, modifies the microbiome composition favourably. Thus, the microbiome presents a key link between polyphenol consumption and the health benefits observed in metabolic conditions in numerous studies. This review will explore the therapeutic value of cereal polyphenols in conjunction with their bioaccessibility, impact on intestinal barrier function and interaction with the microbiome coupled with plasma anti-inflammatory effects. MDPI 2021-07-09 /pmc/articles/PMC8307242/ /pubmed/34359469 http://dx.doi.org/10.3390/foods10071595 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ed Nignpense, Borkwei
Francis, Nidhish
Blanchard, Christopher
Santhakumar, Abishek Bommannan
Bioaccessibility and Bioactivity of Cereal Polyphenols: A Review
title Bioaccessibility and Bioactivity of Cereal Polyphenols: A Review
title_full Bioaccessibility and Bioactivity of Cereal Polyphenols: A Review
title_fullStr Bioaccessibility and Bioactivity of Cereal Polyphenols: A Review
title_full_unstemmed Bioaccessibility and Bioactivity of Cereal Polyphenols: A Review
title_short Bioaccessibility and Bioactivity of Cereal Polyphenols: A Review
title_sort bioaccessibility and bioactivity of cereal polyphenols: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307242/
https://www.ncbi.nlm.nih.gov/pubmed/34359469
http://dx.doi.org/10.3390/foods10071595
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