A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen

SIMPLE SUMMARY: The present study demonstrates that a radiolabeling strategy can positively modify hu5A10′s capacity to bind PSA and complex with the FcRn receptor, which results in a more homogenous activity distribution in tumors and enhanced therapy efficacy. These new innovative radiochemistry i...

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Autores principales: Vilhelmsson Timmermand, Oskar, Örbom, Anders, Altai, Mohamed, Zedan, Wahed, Holmqvist, Bo, Safi, Marcella, Tran, Thuy A., Strand, Sven-Erik, Strand, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307315/
https://www.ncbi.nlm.nih.gov/pubmed/34298682
http://dx.doi.org/10.3390/cancers13143469

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