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Computational design of a synthetic PD-1 agonist

Programmed cell death protein-1 (PD-1) expressed on activated T cells inhibits T cell function and proliferation to prevent an excessive immune response, and disease can result if this delicate balance is shifted in either direction. Tumor cells often take advantage of this pathway by overexpressing...

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Detalles Bibliográficos
Autores principales:	Bryan, Cassie M., Rocklin, Gabriel J., Bick, Matthew J., Ford, Alex, Majri-Morrison, Sonia, Kroll, Ashley V., Miller, Chad J., Carter, Lauren, Goreshnik, Inna, Kang, Alex, DiMaio, Frank, Tarbell, Kristin V., Baker, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307378/ https://www.ncbi.nlm.nih.gov/pubmed/34272285 http://dx.doi.org/10.1073/pnas.2102164118

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