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NMR Spectroscopy for Protein Higher Order Structure Similarity Assessment in Formulated Drug Products

Peptide and protein drug molecules fold into higher order structures (HOS) in formulation and these folded structures are often critical for drug efficacy and safety. Generic or biosimilar drug products (DPs) need to show similar HOS to the reference product. The solution NMR spectroscopy is a non-i...

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Detalles Bibliográficos
Autores principales:	Wang, Deyun, Zhuo, You, Karfunkle, Mike, Patil, Sharadrao M., Smith, Cameron J., Keire, David A., Chen, Kang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307401/ https://www.ncbi.nlm.nih.gov/pubmed/34299526 http://dx.doi.org/10.3390/molecules26144251

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