Cargando…

NMR Spectroscopy for Protein Higher Order Structure Similarity Assessment in Formulated Drug Products

Peptide and protein drug molecules fold into higher order structures (HOS) in formulation and these folded structures are often critical for drug efficacy and safety. Generic or biosimilar drug products (DPs) need to show similar HOS to the reference product. The solution NMR spectroscopy is a non-i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Deyun, Zhuo, You, Karfunkle, Mike, Patil, Sharadrao M., Smith, Cameron J., Keire, David A., Chen, Kang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307401/ https://www.ncbi.nlm.nih.gov/pubmed/34299526 http://dx.doi.org/10.3390/molecules26144251

Ejemplares similares

Combining NMR Spectroscopy and Chemometrics to Monitor Structural Features of Crude Hep-arin
por: Mauri, Lucio, et al.
Publicado: (2017)

1D and 2D-HSQC NMR: Two Methods to Distinguish and Characterize Heparin From Different Animal and Tissue Sources
por: Mauri, Lucio, et al.
Publicado: (2019)

The impact of standard accelerated stability conditions on antibody higher order structure as assessed by mass spectrometry
por: Kerr, Richard A., et al.
Publicado: (2019)

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics
por: Brinson, Robert G., et al.
Publicado: (2018)

Natural products dereplication by diffusion ordered NMR spectroscopy (DOSY)
por: Kleks, Guy, et al.
Publicado: (2021)

SHARPER-DOSY: Sensitivity enhanced diffusion-ordered NMR spectroscopy
por: Peat, George, et al.
Publicado: (2023)

Solution NMR Spectroscopy in Target-Based Drug Discovery
por: Li, Yan, et al.
Publicado: (2017)

Directly Decoupled Diffusion-Ordered NMR Spectroscopy for the Analysis of Compound Mixtures
por: Glanzer, Simon, et al.
Publicado: (2014)

An Evaluation of the Potential of NMR Spectroscopy and Computational Modelling Methods to Inform Biopharmaceutical Formulations
por: Pandya, Akash, et al.
Publicado: (2018)

Using surface plasmon resonance, capillary electrophoresis and diffusion-ordered NMR spectroscopy to study drug release kinetics
por: Libánská, Alena, et al.
Publicado: (2023)

Spatial molecular-dynamically ordered NMR spectroscopy of intact bodies and heterogeneous systems
por: Ito, Kengo, et al.
Publicado: (2020)

A Practical Perspective on the Roles of Solution NMR Spectroscopy in Drug Discovery
por: Li, Qingxin, et al.
Publicado: (2020)

Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches
por: Zhang, Chunting, et al.
Publicado: (2023)

Charge-Based Inhibitors of Amylin Fibrillization and Toxicity
por: Patil, Sharadrao M., et al.
Publicado: (2015)

NMR of ordered liquids
por: Burnell, E Elliott, et al.
Publicado: (2010)

On the Rational Drug Design for Hypertension through NMR Spectroscopy
por: Chontzopoulou, Eleni, et al.
Publicado: (2020)

Characterizing monoclonal antibody formulations in arginine glutamate solutions using (1)H NMR spectroscopy
por: Kheddo, Priscilla, et al.
Publicado: (2016)

Comprehensive Assessment of Protein and Excipient Stability in Biopharmaceutical Formulations Using (1)H NMR Spectroscopy
por: Bramham, Jack E., et al.
Publicado: (2020)

Optimization of Diffusion-Ordered NMR Spectroscopy Experiments for High-Throughput Automation in Human Metabolic Phenotyping
por: Harvey, Nikita, et al.
Publicado: (2023)

NMR spectroscopy techniques /
Publicado: (1996)

Relevance of Higher-Order Epistasis in Drug Resistance
por: Lozovsky, Elena R, et al.
Publicado: (2020)

An Order Reduction Design Framework for Higher-Order Binary Markov Random Fields
por: Chen, Zhuo, et al.
Publicado: (2023)

Prevalence and patterns of higher-order drug interactions in Escherichia coli
por: Tekin, Elif, et al.
Publicado: (2018)

(17)O NMR spectroscopy of crystalline microporous materials
por: Ashbrook, Sharon E., et al.
Publicado: (2021)

NMR spectroscopy : basic principles, concepts, and applications in chemistry /
por: Günther, H. (Harald)
Publicado: (1995)

Gamma NMR spectroscopy experiment
por: Hadjigeorgiou, Andreas
Publicado: (2018)

Solving problems with NMR spectroscopy
por: Rahman, Atta-ur-, 1942-
Publicado: (1996)

Fundamentals of Protein NMR Spectroscopy
por: Rule, Gordon S, et al.
Publicado: (2006)

Ultrahigh-Resolution NMR Spectroscopy**
por: Foroozandeh, Mohammadali, et al.
Publicado: (2014)

NMR Spectroscopy for Metabolomics Research
por: Emwas, Abdul-Hamid, et al.
Publicado: (2019)

RNA Dynamics by NMR Spectroscopy
por: Marušič, Maja, et al.
Publicado: (2019)

Singlet-filtered NMR spectroscopy
por: Mamone, Salvatore, et al.
Publicado: (2020)

NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties
por: Zloh, Mire
Publicado: (2019)

Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency
por: Luchinat, Enrico, et al.
Publicado: (2020)

Modern NMR spectroscopy : a workbook of chemical problems
Publicado: (1993)

Higher-order computability
por: Longley, John, et al.
Publicado: (2015)

Higher Order Derivatives
por: Mukhopadhyay, Satya
Publicado: (2012)

Hidden suppressive interactions are common in higher-order drug combinations
por: Lozano-Huntelman, Natalie Ann, et al.
Publicado: (2021)

Higher-order G-quadruplexes in promoters are untapped drug targets
por: Monsen, Robert C.
Publicado: (2023)

Higher-Order Belief Propagation Correction Decoder for Polar Codes
por: Zhang, Meng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_09s2sbfdk7ebva4kn6sj3qsp80