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Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells

Proper functioning of the body depends on hormonal homeostasis. White adipose tissue is now known as an endocrine organ due to the secretion of multiple molecules called adipokines. These proteins exert direct effects on whole body functions, including lipid metabolism, angiogenesis, inflammation, a...

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Autores principales: Kurowska, Patrycja, Mlyczyńska, Ewa, Dawid, Monika, Jurek, Małgorzata, Klimczyk, Dominika, Dupont, Joelle, Rak, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307435/
https://www.ncbi.nlm.nih.gov/pubmed/34359881
http://dx.doi.org/10.3390/cells10071710
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author Kurowska, Patrycja
Mlyczyńska, Ewa
Dawid, Monika
Jurek, Małgorzata
Klimczyk, Dominika
Dupont, Joelle
Rak, Agnieszka
author_facet Kurowska, Patrycja
Mlyczyńska, Ewa
Dawid, Monika
Jurek, Małgorzata
Klimczyk, Dominika
Dupont, Joelle
Rak, Agnieszka
author_sort Kurowska, Patrycja
collection PubMed
description Proper functioning of the body depends on hormonal homeostasis. White adipose tissue is now known as an endocrine organ due to the secretion of multiple molecules called adipokines. These proteins exert direct effects on whole body functions, including lipid metabolism, angiogenesis, inflammation, and reproduction, whereas changes in their level are linked with pathological events, such as infertility, diabetes, and increased food intake. Vaspin-visceral adipose tissue-derived serine protease inhibitor, or SERPINA12 according to serpin nomenclature, is an adipokine discovered in 2005 that is connected to the development of insulin resistance, obesity, and inflammation. A significantly higher amount of vaspin was observed in obese patients. The objective of this review was to summarize the latest findings about vaspin expression and action in endocrine tissues, such as the hypothalamus, pituitary gland, adipose tissue, thyroid, ovary, placenta, and testis, as well as discuss the link between vaspin and pathologies connected with hormonal imbalance.
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spelling pubmed-83074352021-07-25 Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells Kurowska, Patrycja Mlyczyńska, Ewa Dawid, Monika Jurek, Małgorzata Klimczyk, Dominika Dupont, Joelle Rak, Agnieszka Cells Review Proper functioning of the body depends on hormonal homeostasis. White adipose tissue is now known as an endocrine organ due to the secretion of multiple molecules called adipokines. These proteins exert direct effects on whole body functions, including lipid metabolism, angiogenesis, inflammation, and reproduction, whereas changes in their level are linked with pathological events, such as infertility, diabetes, and increased food intake. Vaspin-visceral adipose tissue-derived serine protease inhibitor, or SERPINA12 according to serpin nomenclature, is an adipokine discovered in 2005 that is connected to the development of insulin resistance, obesity, and inflammation. A significantly higher amount of vaspin was observed in obese patients. The objective of this review was to summarize the latest findings about vaspin expression and action in endocrine tissues, such as the hypothalamus, pituitary gland, adipose tissue, thyroid, ovary, placenta, and testis, as well as discuss the link between vaspin and pathologies connected with hormonal imbalance. MDPI 2021-07-06 /pmc/articles/PMC8307435/ /pubmed/34359881 http://dx.doi.org/10.3390/cells10071710 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kurowska, Patrycja
Mlyczyńska, Ewa
Dawid, Monika
Jurek, Małgorzata
Klimczyk, Dominika
Dupont, Joelle
Rak, Agnieszka
Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells
title Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells
title_full Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells
title_fullStr Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells
title_full_unstemmed Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells
title_short Review: Vaspin (SERPINA12) Expression and Function in Endocrine Cells
title_sort review: vaspin (serpina12) expression and function in endocrine cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307435/
https://www.ncbi.nlm.nih.gov/pubmed/34359881
http://dx.doi.org/10.3390/cells10071710
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