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Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous and challenging. Over the past decades, there has been an increasing body of literature related to the effects of secondary metabolites from...

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Autores principales: Shehadeh, Mayadah Bashir, Suaifan, Ghadeer A. R. Y., Abu-Odeh, Ala’ Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307461/
https://www.ncbi.nlm.nih.gov/pubmed/34299610
http://dx.doi.org/10.3390/molecules26144333
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author Shehadeh, Mayadah Bashir
Suaifan, Ghadeer A. R. Y.
Abu-Odeh, Ala’ Mustafa
author_facet Shehadeh, Mayadah Bashir
Suaifan, Ghadeer A. R. Y.
Abu-Odeh, Ala’ Mustafa
author_sort Shehadeh, Mayadah Bashir
collection PubMed
description Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous and challenging. Over the past decades, there has been an increasing body of literature related to the effects of secondary metabolites from botanical sources on diabetes. Plants-derived metabolites including alkaloids, phenols, anthocyanins, flavonoids, stilbenoids, saponins, tannins, polysaccharides, coumarins, and terpenes can target cellular and molecular mechanisms involved in carbohydrate metabolism. In addition, they can grant protection to pancreatic beta cells from damage, repairing abnormal insulin signaling, minimizing oxidative stress and inflammation, activating AMP-activated protein kinase (AMPK), and inhibiting carbohydrate digestion and absorption. Studies have highlighted many bioactive naturally occurring plants’ secondary metabolites as candidates against diabetes. This review summarizes the current knowledge compiled from the latest studies published during the past decade on the mechanism-based action of plants-derived secondary metabolites that can target various metabolic pathways in humans against diabetes. It is worth mentioning that the compiled data in this review will provide a guide for researchers in the field, to develop candidates into environment-friendly effective, yet safe antidiabetics.
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spelling pubmed-83074612021-07-25 Plants Secondary Metabolites as Blood Glucose-Lowering Molecules Shehadeh, Mayadah Bashir Suaifan, Ghadeer A. R. Y. Abu-Odeh, Ala’ Mustafa Molecules Review Recently, significant advances in modern medicine and therapeutic agents have been achieved. However, the search for effective antidiabetic drugs is continuous and challenging. Over the past decades, there has been an increasing body of literature related to the effects of secondary metabolites from botanical sources on diabetes. Plants-derived metabolites including alkaloids, phenols, anthocyanins, flavonoids, stilbenoids, saponins, tannins, polysaccharides, coumarins, and terpenes can target cellular and molecular mechanisms involved in carbohydrate metabolism. In addition, they can grant protection to pancreatic beta cells from damage, repairing abnormal insulin signaling, minimizing oxidative stress and inflammation, activating AMP-activated protein kinase (AMPK), and inhibiting carbohydrate digestion and absorption. Studies have highlighted many bioactive naturally occurring plants’ secondary metabolites as candidates against diabetes. This review summarizes the current knowledge compiled from the latest studies published during the past decade on the mechanism-based action of plants-derived secondary metabolites that can target various metabolic pathways in humans against diabetes. It is worth mentioning that the compiled data in this review will provide a guide for researchers in the field, to develop candidates into environment-friendly effective, yet safe antidiabetics. MDPI 2021-07-17 /pmc/articles/PMC8307461/ /pubmed/34299610 http://dx.doi.org/10.3390/molecules26144333 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shehadeh, Mayadah Bashir
Suaifan, Ghadeer A. R. Y.
Abu-Odeh, Ala’ Mustafa
Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
title Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
title_full Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
title_fullStr Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
title_full_unstemmed Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
title_short Plants Secondary Metabolites as Blood Glucose-Lowering Molecules
title_sort plants secondary metabolites as blood glucose-lowering molecules
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307461/
https://www.ncbi.nlm.nih.gov/pubmed/34299610
http://dx.doi.org/10.3390/molecules26144333
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