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Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury

Hypothermia has been used in postoperative management of traumatic brain injury (TBI); however, the rhythmic variation and prognostic value of brain temperature after TBI have never been studied. This study describes diurnal brain temperature patterns in comatose patients with TBI. Mesors of brain t...

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Autores principales: Kuo, Lu-Ting, Lu, Hsueh-Yi, Huang, Abel Po-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307466/
https://www.ncbi.nlm.nih.gov/pubmed/34208924
http://dx.doi.org/10.3390/jpm11070620
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author Kuo, Lu-Ting
Lu, Hsueh-Yi
Huang, Abel Po-Hao
author_facet Kuo, Lu-Ting
Lu, Hsueh-Yi
Huang, Abel Po-Hao
author_sort Kuo, Lu-Ting
collection PubMed
description Hypothermia has been used in postoperative management of traumatic brain injury (TBI); however, the rhythmic variation and prognostic value of brain temperature after TBI have never been studied. This study describes diurnal brain temperature patterns in comatose patients with TBI. Mesors of brain temperature, amplitude, and acrophase were estimated from recorded temperature measurements using cosinor analysis. The association of these patterns with clinical parameters, mortality, and functional outcomes in a 12-month follow-up was examined. According to the cosinor analysis, 59.3% of patients presented with circadian rhythms of brain temperature in the first 72 h postoperatively. The rhythm-adjusted mesor of brain temperature was 37.39 ± 1.21 °C, with a diminished mean amplitude of 0.28 (±0.25) °C; a shift of temperature acrophase was also observed. Multivariate logistic regression analysis revealed that initial Glasgow coma scale score, age, elevated blood glucose level, and circadian rhythm of brain temperature seemed to be predictive and prognostic factors of patients’ functional outcomes. For the prediction of survival status, younger patients or those patients with mesor within the middle 50% of brain temperature were more likely to survive. The analysis of brain temperature rhythms in patients with moderate and severe TBI provided additional predictive information related to mortality and functional outcomes.
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spelling pubmed-83074662021-07-25 Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury Kuo, Lu-Ting Lu, Hsueh-Yi Huang, Abel Po-Hao J Pers Med Article Hypothermia has been used in postoperative management of traumatic brain injury (TBI); however, the rhythmic variation and prognostic value of brain temperature after TBI have never been studied. This study describes diurnal brain temperature patterns in comatose patients with TBI. Mesors of brain temperature, amplitude, and acrophase were estimated from recorded temperature measurements using cosinor analysis. The association of these patterns with clinical parameters, mortality, and functional outcomes in a 12-month follow-up was examined. According to the cosinor analysis, 59.3% of patients presented with circadian rhythms of brain temperature in the first 72 h postoperatively. The rhythm-adjusted mesor of brain temperature was 37.39 ± 1.21 °C, with a diminished mean amplitude of 0.28 (±0.25) °C; a shift of temperature acrophase was also observed. Multivariate logistic regression analysis revealed that initial Glasgow coma scale score, age, elevated blood glucose level, and circadian rhythm of brain temperature seemed to be predictive and prognostic factors of patients’ functional outcomes. For the prediction of survival status, younger patients or those patients with mesor within the middle 50% of brain temperature were more likely to survive. The analysis of brain temperature rhythms in patients with moderate and severe TBI provided additional predictive information related to mortality and functional outcomes. MDPI 2021-06-30 /pmc/articles/PMC8307466/ /pubmed/34208924 http://dx.doi.org/10.3390/jpm11070620 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kuo, Lu-Ting
Lu, Hsueh-Yi
Huang, Abel Po-Hao
Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury
title Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury
title_full Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury
title_fullStr Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury
title_full_unstemmed Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury
title_short Prognostic Value of Circadian Rhythm of Brain Temperature in Traumatic Brain Injury
title_sort prognostic value of circadian rhythm of brain temperature in traumatic brain injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307466/
https://www.ncbi.nlm.nih.gov/pubmed/34208924
http://dx.doi.org/10.3390/jpm11070620
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