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Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois
Individuals living in areas with the potential for elevated metal exposure from industrial sources may have reduced pulmonary function. We evaluated cross-sectional associations of toenail concentrations of 17 metals within a community area of residence and asthma control in 75 children, and pulmona...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307469/ https://www.ncbi.nlm.nih.gov/pubmed/34299734 http://dx.doi.org/10.3390/ijerph18147279 |
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author | Madrigal, Jessica M. Persky, Victoria Jackson, Brian P. Bain, Amy Siemer, Matt Pappalardo, Andrea A. Argos, Maria |
author_facet | Madrigal, Jessica M. Persky, Victoria Jackson, Brian P. Bain, Amy Siemer, Matt Pappalardo, Andrea A. Argos, Maria |
author_sort | Madrigal, Jessica M. |
collection | PubMed |
description | Individuals living in areas with the potential for elevated metal exposure from industrial sources may have reduced pulmonary function. We evaluated cross-sectional associations of toenail concentrations of 17 metals within a community area of residence and asthma control in 75 children, and pulmonary function measures [forced expiratory volume in one second (FEV1; liters), forced vital capacity (FVC; liters), FEV1 to FVC ratio (FEV1:FVC), and mid-exhalation forced expiratory flow rate (FEF 25–75%; liters/second)], in a subsample of 39 children with diagnosed asthma in Chicago, Illinois. Linear regression models were used to estimate adjusted regression coefficients and standard errors (SE) for the associations between ≥ median versus <median metal exposures and natural log-transformed (ln) pulmonary function test parameters. Toenail levels of cadmium, cobalt, iron, manganese, and vanadium were higher among children residing near an industrial corridor than those in a comparison community. Copper concentrations were inversely associated with lnFEV1 (β = −0.10, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02) and lnFEF 25–75% (β = −0.25, SE = 0.09, p = 0.01); manganese concentrations were inversely associated with lnFEV1 (β = −0.11, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02), and lnFEF 25–75% (β = −0.28, SE = 0.10, p = 0.004), and vanadium concentrations were inversely associated with lnFEV1 (β = −0.08, SE = 0.04, p = 0.05) and lnFVC (β = −0.07, SE = 0.03, p = 0.03). Nickel and copper were associated with uncontrolled asthma (OR = 6.8; 95% CI 2.0, 22.8 and OR = 4.6; 95% CI 1.0, 21.0, respectively). These data suggest that selected metal exposures may be associated with impaired pulmonary function parameters and reduced asthma control among children with preexisting asthma. |
format | Online Article Text |
id | pubmed-8307469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83074692021-07-25 Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois Madrigal, Jessica M. Persky, Victoria Jackson, Brian P. Bain, Amy Siemer, Matt Pappalardo, Andrea A. Argos, Maria Int J Environ Res Public Health Article Individuals living in areas with the potential for elevated metal exposure from industrial sources may have reduced pulmonary function. We evaluated cross-sectional associations of toenail concentrations of 17 metals within a community area of residence and asthma control in 75 children, and pulmonary function measures [forced expiratory volume in one second (FEV1; liters), forced vital capacity (FVC; liters), FEV1 to FVC ratio (FEV1:FVC), and mid-exhalation forced expiratory flow rate (FEF 25–75%; liters/second)], in a subsample of 39 children with diagnosed asthma in Chicago, Illinois. Linear regression models were used to estimate adjusted regression coefficients and standard errors (SE) for the associations between ≥ median versus <median metal exposures and natural log-transformed (ln) pulmonary function test parameters. Toenail levels of cadmium, cobalt, iron, manganese, and vanadium were higher among children residing near an industrial corridor than those in a comparison community. Copper concentrations were inversely associated with lnFEV1 (β = −0.10, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02) and lnFEF 25–75% (β = −0.25, SE = 0.09, p = 0.01); manganese concentrations were inversely associated with lnFEV1 (β = −0.11, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02), and lnFEF 25–75% (β = −0.28, SE = 0.10, p = 0.004), and vanadium concentrations were inversely associated with lnFEV1 (β = −0.08, SE = 0.04, p = 0.05) and lnFVC (β = −0.07, SE = 0.03, p = 0.03). Nickel and copper were associated with uncontrolled asthma (OR = 6.8; 95% CI 2.0, 22.8 and OR = 4.6; 95% CI 1.0, 21.0, respectively). These data suggest that selected metal exposures may be associated with impaired pulmonary function parameters and reduced asthma control among children with preexisting asthma. MDPI 2021-07-07 /pmc/articles/PMC8307469/ /pubmed/34299734 http://dx.doi.org/10.3390/ijerph18147279 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Madrigal, Jessica M. Persky, Victoria Jackson, Brian P. Bain, Amy Siemer, Matt Pappalardo, Andrea A. Argos, Maria Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois |
title | Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois |
title_full | Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois |
title_fullStr | Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois |
title_full_unstemmed | Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois |
title_short | Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois |
title_sort | assessment of metal concentrations and associations with pulmonary function among children with asthma in chicago, illinois |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307469/ https://www.ncbi.nlm.nih.gov/pubmed/34299734 http://dx.doi.org/10.3390/ijerph18147279 |
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