Cargando…

Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois

Individuals living in areas with the potential for elevated metal exposure from industrial sources may have reduced pulmonary function. We evaluated cross-sectional associations of toenail concentrations of 17 metals within a community area of residence and asthma control in 75 children, and pulmona...

Descripción completa

Detalles Bibliográficos
Autores principales: Madrigal, Jessica M., Persky, Victoria, Jackson, Brian P., Bain, Amy, Siemer, Matt, Pappalardo, Andrea A., Argos, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307469/
https://www.ncbi.nlm.nih.gov/pubmed/34299734
http://dx.doi.org/10.3390/ijerph18147279
_version_ 1783728056998821888
author Madrigal, Jessica M.
Persky, Victoria
Jackson, Brian P.
Bain, Amy
Siemer, Matt
Pappalardo, Andrea A.
Argos, Maria
author_facet Madrigal, Jessica M.
Persky, Victoria
Jackson, Brian P.
Bain, Amy
Siemer, Matt
Pappalardo, Andrea A.
Argos, Maria
author_sort Madrigal, Jessica M.
collection PubMed
description Individuals living in areas with the potential for elevated metal exposure from industrial sources may have reduced pulmonary function. We evaluated cross-sectional associations of toenail concentrations of 17 metals within a community area of residence and asthma control in 75 children, and pulmonary function measures [forced expiratory volume in one second (FEV1; liters), forced vital capacity (FVC; liters), FEV1 to FVC ratio (FEV1:FVC), and mid-exhalation forced expiratory flow rate (FEF 25–75%; liters/second)], in a subsample of 39 children with diagnosed asthma in Chicago, Illinois. Linear regression models were used to estimate adjusted regression coefficients and standard errors (SE) for the associations between ≥ median versus <median metal exposures and natural log-transformed (ln) pulmonary function test parameters. Toenail levels of cadmium, cobalt, iron, manganese, and vanadium were higher among children residing near an industrial corridor than those in a comparison community. Copper concentrations were inversely associated with lnFEV1 (β = −0.10, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02) and lnFEF 25–75% (β = −0.25, SE = 0.09, p = 0.01); manganese concentrations were inversely associated with lnFEV1 (β = −0.11, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02), and lnFEF 25–75% (β = −0.28, SE = 0.10, p = 0.004), and vanadium concentrations were inversely associated with lnFEV1 (β = −0.08, SE = 0.04, p = 0.05) and lnFVC (β = −0.07, SE = 0.03, p = 0.03). Nickel and copper were associated with uncontrolled asthma (OR = 6.8; 95% CI 2.0, 22.8 and OR = 4.6; 95% CI 1.0, 21.0, respectively). These data suggest that selected metal exposures may be associated with impaired pulmonary function parameters and reduced asthma control among children with preexisting asthma.
format Online
Article
Text
id pubmed-8307469
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83074692021-07-25 Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois Madrigal, Jessica M. Persky, Victoria Jackson, Brian P. Bain, Amy Siemer, Matt Pappalardo, Andrea A. Argos, Maria Int J Environ Res Public Health Article Individuals living in areas with the potential for elevated metal exposure from industrial sources may have reduced pulmonary function. We evaluated cross-sectional associations of toenail concentrations of 17 metals within a community area of residence and asthma control in 75 children, and pulmonary function measures [forced expiratory volume in one second (FEV1; liters), forced vital capacity (FVC; liters), FEV1 to FVC ratio (FEV1:FVC), and mid-exhalation forced expiratory flow rate (FEF 25–75%; liters/second)], in a subsample of 39 children with diagnosed asthma in Chicago, Illinois. Linear regression models were used to estimate adjusted regression coefficients and standard errors (SE) for the associations between ≥ median versus <median metal exposures and natural log-transformed (ln) pulmonary function test parameters. Toenail levels of cadmium, cobalt, iron, manganese, and vanadium were higher among children residing near an industrial corridor than those in a comparison community. Copper concentrations were inversely associated with lnFEV1 (β = −0.10, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02) and lnFEF 25–75% (β = −0.25, SE = 0.09, p = 0.01); manganese concentrations were inversely associated with lnFEV1 (β = −0.11, SE = 0.04, p = 0.01), lnFEV1:FVC (β = −0.07, SE = 0.03, p = 0.02), and lnFEF 25–75% (β = −0.28, SE = 0.10, p = 0.004), and vanadium concentrations were inversely associated with lnFEV1 (β = −0.08, SE = 0.04, p = 0.05) and lnFVC (β = −0.07, SE = 0.03, p = 0.03). Nickel and copper were associated with uncontrolled asthma (OR = 6.8; 95% CI 2.0, 22.8 and OR = 4.6; 95% CI 1.0, 21.0, respectively). These data suggest that selected metal exposures may be associated with impaired pulmonary function parameters and reduced asthma control among children with preexisting asthma. MDPI 2021-07-07 /pmc/articles/PMC8307469/ /pubmed/34299734 http://dx.doi.org/10.3390/ijerph18147279 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Madrigal, Jessica M.
Persky, Victoria
Jackson, Brian P.
Bain, Amy
Siemer, Matt
Pappalardo, Andrea A.
Argos, Maria
Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois
title Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois
title_full Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois
title_fullStr Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois
title_full_unstemmed Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois
title_short Assessment of Metal Concentrations and Associations with Pulmonary Function among Children with Asthma in Chicago, Illinois
title_sort assessment of metal concentrations and associations with pulmonary function among children with asthma in chicago, illinois
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307469/
https://www.ncbi.nlm.nih.gov/pubmed/34299734
http://dx.doi.org/10.3390/ijerph18147279
work_keys_str_mv AT madrigaljessicam assessmentofmetalconcentrationsandassociationswithpulmonaryfunctionamongchildrenwithasthmainchicagoillinois
AT perskyvictoria assessmentofmetalconcentrationsandassociationswithpulmonaryfunctionamongchildrenwithasthmainchicagoillinois
AT jacksonbrianp assessmentofmetalconcentrationsandassociationswithpulmonaryfunctionamongchildrenwithasthmainchicagoillinois
AT bainamy assessmentofmetalconcentrationsandassociationswithpulmonaryfunctionamongchildrenwithasthmainchicagoillinois
AT siemermatt assessmentofmetalconcentrationsandassociationswithpulmonaryfunctionamongchildrenwithasthmainchicagoillinois
AT pappalardoandreaa assessmentofmetalconcentrationsandassociationswithpulmonaryfunctionamongchildrenwithasthmainchicagoillinois
AT argosmaria assessmentofmetalconcentrationsandassociationswithpulmonaryfunctionamongchildrenwithasthmainchicagoillinois