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A History of Heart Failure Is an Independent Risk Factor for Death in Patients Admitted with Coronavirus 19 Disease

Aims: The association between cardiovascular diseases, such as coronary artery disease and hypertension, and worse outcomes in COVID-19 patients has been previously demonstrated. However, the effect of a prior diagnosis of heart failure (HF) with reduced or preserved left ventricular ejection fracti...

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Autores principales: Castagna, Francesco, Kataria, Rachna, Madan, Shivank, Ali, Syed Zain, Diab, Karim, Leyton, Christopher, Arfaras-Melainis, Angelos, Kim, Paul, Giorgi, Federico M., Vukelic, Sasa, Saeed, Omar, Patel, Snehal R., Sims, Daniel B., Jorde, Ulrich P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307512/
https://www.ncbi.nlm.nih.gov/pubmed/34209143
http://dx.doi.org/10.3390/jcdd8070077
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author Castagna, Francesco
Kataria, Rachna
Madan, Shivank
Ali, Syed Zain
Diab, Karim
Leyton, Christopher
Arfaras-Melainis, Angelos
Kim, Paul
Giorgi, Federico M.
Vukelic, Sasa
Saeed, Omar
Patel, Snehal R.
Sims, Daniel B.
Jorde, Ulrich P.
author_facet Castagna, Francesco
Kataria, Rachna
Madan, Shivank
Ali, Syed Zain
Diab, Karim
Leyton, Christopher
Arfaras-Melainis, Angelos
Kim, Paul
Giorgi, Federico M.
Vukelic, Sasa
Saeed, Omar
Patel, Snehal R.
Sims, Daniel B.
Jorde, Ulrich P.
author_sort Castagna, Francesco
collection PubMed
description Aims: The association between cardiovascular diseases, such as coronary artery disease and hypertension, and worse outcomes in COVID-19 patients has been previously demonstrated. However, the effect of a prior diagnosis of heart failure (HF) with reduced or preserved left ventricular ejection fraction on COVID-19 outcomes has not yet been established. Methods and Results: We retrospectively studied all adult patients with COVID-19 admitted to our institution from March 1st to 2nd May 2020. Patients were grouped based on the presence or absence of HF. We used competing events survival models to examine the association between HF and death, need for intubation, or need for dialysis during hospitalization. Of 4043 patients admitted with COVID-19, 335 patients (8.3%) had a prior diagnosis of HF. Patients with HF were older, had lower body mass index, and a significantly higher burden of co-morbidities compared to patients without HF, yet the two groups presented to the hospital with similar clinical severity and similar markers of systemic inflammation. Patients with HF had a higher cumulative in-hospital mortality compared to patients without HF (49.0% vs. 27.2%, p < 0.001) that remained statistically significant (HR = 1.383, p = 0.001) after adjustment for age, body mass index, and comorbidities, as well as after propensity score matching (HR = 1.528, p = 0.001). Notably, no differences in mortality, need for mechanical ventilation, or renal replacement therapy were observed among HF patients with preserved or reduced ejection fraction. Conclusions: The presence of HF is a risk factor of death, substantially increasing in-hospital mortality in patients admitted with COVID-19.
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spelling pubmed-83075122021-07-25 A History of Heart Failure Is an Independent Risk Factor for Death in Patients Admitted with Coronavirus 19 Disease Castagna, Francesco Kataria, Rachna Madan, Shivank Ali, Syed Zain Diab, Karim Leyton, Christopher Arfaras-Melainis, Angelos Kim, Paul Giorgi, Federico M. Vukelic, Sasa Saeed, Omar Patel, Snehal R. Sims, Daniel B. Jorde, Ulrich P. J Cardiovasc Dev Dis Article Aims: The association between cardiovascular diseases, such as coronary artery disease and hypertension, and worse outcomes in COVID-19 patients has been previously demonstrated. However, the effect of a prior diagnosis of heart failure (HF) with reduced or preserved left ventricular ejection fraction on COVID-19 outcomes has not yet been established. Methods and Results: We retrospectively studied all adult patients with COVID-19 admitted to our institution from March 1st to 2nd May 2020. Patients were grouped based on the presence or absence of HF. We used competing events survival models to examine the association between HF and death, need for intubation, or need for dialysis during hospitalization. Of 4043 patients admitted with COVID-19, 335 patients (8.3%) had a prior diagnosis of HF. Patients with HF were older, had lower body mass index, and a significantly higher burden of co-morbidities compared to patients without HF, yet the two groups presented to the hospital with similar clinical severity and similar markers of systemic inflammation. Patients with HF had a higher cumulative in-hospital mortality compared to patients without HF (49.0% vs. 27.2%, p < 0.001) that remained statistically significant (HR = 1.383, p = 0.001) after adjustment for age, body mass index, and comorbidities, as well as after propensity score matching (HR = 1.528, p = 0.001). Notably, no differences in mortality, need for mechanical ventilation, or renal replacement therapy were observed among HF patients with preserved or reduced ejection fraction. Conclusions: The presence of HF is a risk factor of death, substantially increasing in-hospital mortality in patients admitted with COVID-19. MDPI 2021-06-30 /pmc/articles/PMC8307512/ /pubmed/34209143 http://dx.doi.org/10.3390/jcdd8070077 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Castagna, Francesco
Kataria, Rachna
Madan, Shivank
Ali, Syed Zain
Diab, Karim
Leyton, Christopher
Arfaras-Melainis, Angelos
Kim, Paul
Giorgi, Federico M.
Vukelic, Sasa
Saeed, Omar
Patel, Snehal R.
Sims, Daniel B.
Jorde, Ulrich P.
A History of Heart Failure Is an Independent Risk Factor for Death in Patients Admitted with Coronavirus 19 Disease
title A History of Heart Failure Is an Independent Risk Factor for Death in Patients Admitted with Coronavirus 19 Disease
title_full A History of Heart Failure Is an Independent Risk Factor for Death in Patients Admitted with Coronavirus 19 Disease
title_fullStr A History of Heart Failure Is an Independent Risk Factor for Death in Patients Admitted with Coronavirus 19 Disease
title_full_unstemmed A History of Heart Failure Is an Independent Risk Factor for Death in Patients Admitted with Coronavirus 19 Disease
title_short A History of Heart Failure Is an Independent Risk Factor for Death in Patients Admitted with Coronavirus 19 Disease
title_sort history of heart failure is an independent risk factor for death in patients admitted with coronavirus 19 disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307512/
https://www.ncbi.nlm.nih.gov/pubmed/34209143
http://dx.doi.org/10.3390/jcdd8070077
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