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Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin

We studied CD34+ stromal cells/telocytes (CD34+SCs/TCs) in pathologic skin, after briefly examining them in normal conditions. We confirm previous studies by other authors in the normal dermis regarding CD34+SC/TC characteristics and distribution around vessels, nerves and cutaneous annexes, highlig...

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Autores principales: Díaz-Flores, Lucio, Gutiérrez, Ricardo, García, Maria Pino, González-Gómez, Miriam, Rodríguez-Rodriguez, Rosa, Hernández-León, Nieves, Carrasco, José Luís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307573/
https://www.ncbi.nlm.nih.gov/pubmed/34298962
http://dx.doi.org/10.3390/ijms22147342
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author Díaz-Flores, Lucio
Gutiérrez, Ricardo
García, Maria Pino
González-Gómez, Miriam
Rodríguez-Rodriguez, Rosa
Hernández-León, Nieves
Díaz-Flores, Lucio
Carrasco, José Luís
author_facet Díaz-Flores, Lucio
Gutiérrez, Ricardo
García, Maria Pino
González-Gómez, Miriam
Rodríguez-Rodriguez, Rosa
Hernández-León, Nieves
Díaz-Flores, Lucio
Carrasco, José Luís
author_sort Díaz-Flores, Lucio
collection PubMed
description We studied CD34+ stromal cells/telocytes (CD34+SCs/TCs) in pathologic skin, after briefly examining them in normal conditions. We confirm previous studies by other authors in the normal dermis regarding CD34+SC/TC characteristics and distribution around vessels, nerves and cutaneous annexes, highlighting their practical absence in the papillary dermis and presence in the bulge region of perifollicular groups of very small CD34+ stromal cells. In non-tumoral skin pathology, we studied examples of the principal histologic patterns in which CD34+SCs/TCs have (1) a fundamental pathophysiological role, including (a) fibrosing/sclerosing diseases, such as systemic sclerosis, with loss of CD34+SCs/TCs and presence of stromal cells co-expressing CD34 and αSMA, and (b) metabolic degenerative processes, including basophilic degeneration of collagen, with stromal cells/telocytes in close association with degenerative fibrils, and cutaneous myxoid cysts with spindle-shaped, stellate and bulky vacuolated CD34+ stromal cells, and (2) a secondary reactive role, encompassing dermatitis—e.g., interface (erythema multiforme), acantholytic (pemphigus, Hailey–Hailey disease), lichenoid (lichen planus), subepidermal vesicular (bullous pemphigoid), psoriasiform (psoriasis), granulomatous (granuloma annulare)—vasculitis (leukocytoclastic and lymphocytic vasculitis), folliculitis, perifolliculitis and inflammation of the sweat and sebaceous glands (perifolliculitis and rosacea) and infectious dermatitis (verruca vulgaris). In skin tumor and tumor-like conditions, we studied examples of those in which CD34+ stromal cells are (1) the neoplastic component (dermatofibrosarcoma protuberans, sclerotic fibroma and solitary fibrous tumor), (2) a neoplastic component with varying presentation (fibroepithelial polyp and superficial myxofibrosarcoma) and (3) a reactive component in other tumor/tumor-like cell lines, such as those deriving from vessel periendothelial cells (myopericytoma), epithelial cells (trichoepithelioma, nevus sebaceous of Jadassohn and seborrheic keratosis), Merkel cells (Merkel cell carcinoma), melanocytes (dermal melanocytic nevi) and Schwann cells (neurofibroma and granular cell tumor).
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spelling pubmed-83075732021-07-25 Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin Díaz-Flores, Lucio Gutiérrez, Ricardo García, Maria Pino González-Gómez, Miriam Rodríguez-Rodriguez, Rosa Hernández-León, Nieves Díaz-Flores, Lucio Carrasco, José Luís Int J Mol Sci Review We studied CD34+ stromal cells/telocytes (CD34+SCs/TCs) in pathologic skin, after briefly examining them in normal conditions. We confirm previous studies by other authors in the normal dermis regarding CD34+SC/TC characteristics and distribution around vessels, nerves and cutaneous annexes, highlighting their practical absence in the papillary dermis and presence in the bulge region of perifollicular groups of very small CD34+ stromal cells. In non-tumoral skin pathology, we studied examples of the principal histologic patterns in which CD34+SCs/TCs have (1) a fundamental pathophysiological role, including (a) fibrosing/sclerosing diseases, such as systemic sclerosis, with loss of CD34+SCs/TCs and presence of stromal cells co-expressing CD34 and αSMA, and (b) metabolic degenerative processes, including basophilic degeneration of collagen, with stromal cells/telocytes in close association with degenerative fibrils, and cutaneous myxoid cysts with spindle-shaped, stellate and bulky vacuolated CD34+ stromal cells, and (2) a secondary reactive role, encompassing dermatitis—e.g., interface (erythema multiforme), acantholytic (pemphigus, Hailey–Hailey disease), lichenoid (lichen planus), subepidermal vesicular (bullous pemphigoid), psoriasiform (psoriasis), granulomatous (granuloma annulare)—vasculitis (leukocytoclastic and lymphocytic vasculitis), folliculitis, perifolliculitis and inflammation of the sweat and sebaceous glands (perifolliculitis and rosacea) and infectious dermatitis (verruca vulgaris). In skin tumor and tumor-like conditions, we studied examples of those in which CD34+ stromal cells are (1) the neoplastic component (dermatofibrosarcoma protuberans, sclerotic fibroma and solitary fibrous tumor), (2) a neoplastic component with varying presentation (fibroepithelial polyp and superficial myxofibrosarcoma) and (3) a reactive component in other tumor/tumor-like cell lines, such as those deriving from vessel periendothelial cells (myopericytoma), epithelial cells (trichoepithelioma, nevus sebaceous of Jadassohn and seborrheic keratosis), Merkel cells (Merkel cell carcinoma), melanocytes (dermal melanocytic nevi) and Schwann cells (neurofibroma and granular cell tumor). MDPI 2021-07-08 /pmc/articles/PMC8307573/ /pubmed/34298962 http://dx.doi.org/10.3390/ijms22147342 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Díaz-Flores, Lucio
Gutiérrez, Ricardo
García, Maria Pino
González-Gómez, Miriam
Rodríguez-Rodriguez, Rosa
Hernández-León, Nieves
Díaz-Flores, Lucio
Carrasco, José Luís
Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin
title Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin
title_full Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin
title_fullStr Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin
title_full_unstemmed Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin
title_short Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin
title_sort cd34+ stromal cells/telocytes in normal and pathological skin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307573/
https://www.ncbi.nlm.nih.gov/pubmed/34298962
http://dx.doi.org/10.3390/ijms22147342
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