The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives

Increased life expectancy in combination with modern life style and high prevalence of obesity are important risk factors for development of neurodegenerative diseases. Neuroinflammation is a feature of neurodegenerative diseases, and microglia, the innate immune cells of the brain, are central play...

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Detalles Bibliográficos
Autor principal: Alexaki, Vasileia Ismini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307603/
https://www.ncbi.nlm.nih.gov/pubmed/34201844
http://dx.doi.org/10.3390/cells10071584
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author Alexaki, Vasileia Ismini
author_facet Alexaki, Vasileia Ismini
author_sort Alexaki, Vasileia Ismini
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description Increased life expectancy in combination with modern life style and high prevalence of obesity are important risk factors for development of neurodegenerative diseases. Neuroinflammation is a feature of neurodegenerative diseases, and microglia, the innate immune cells of the brain, are central players in it. The present review discusses the effects of obesity, chronic peripheral inflammation and obesity-associated metabolic and endocrine perturbations, including insulin resistance, dyslipidemia and increased glucocorticoid levels, on microglial function.
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spelling pubmed-83076032021-07-25 The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives Alexaki, Vasileia Ismini Cells Review Increased life expectancy in combination with modern life style and high prevalence of obesity are important risk factors for development of neurodegenerative diseases. Neuroinflammation is a feature of neurodegenerative diseases, and microglia, the innate immune cells of the brain, are central players in it. The present review discusses the effects of obesity, chronic peripheral inflammation and obesity-associated metabolic and endocrine perturbations, including insulin resistance, dyslipidemia and increased glucocorticoid levels, on microglial function. MDPI 2021-06-23 /pmc/articles/PMC8307603/ /pubmed/34201844 http://dx.doi.org/10.3390/cells10071584 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alexaki, Vasileia Ismini
The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
title The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
title_full The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
title_fullStr The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
title_full_unstemmed The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
title_short The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
title_sort impact of obesity on microglial function: immune, metabolic and endocrine perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307603/
https://www.ncbi.nlm.nih.gov/pubmed/34201844
http://dx.doi.org/10.3390/cells10071584
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