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Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model

Despite a wide range of bactericides and antiseptics, the treatment of chronic or complicated wounds is still a major challenge for modern medicine. Topical medications are the most sought-after new agents for use as treatment. The therapeutic concentration of their active substances is easy to achi...

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Autores principales: Szwedowicz, Urszula, Szewczyk, Anna, Gołąb, Krzysztof, Choromańska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307677/
https://www.ncbi.nlm.nih.gov/pubmed/34299351
http://dx.doi.org/10.3390/ijms22147728
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author Szwedowicz, Urszula
Szewczyk, Anna
Gołąb, Krzysztof
Choromańska, Anna
author_facet Szwedowicz, Urszula
Szewczyk, Anna
Gołąb, Krzysztof
Choromańska, Anna
author_sort Szwedowicz, Urszula
collection PubMed
description Despite a wide range of bactericides and antiseptics, the treatment of chronic or complicated wounds is still a major challenge for modern medicine. Topical medications are the most sought-after new agents for use as treatment. The therapeutic concentration of their active substances is easy to achieve with the lowest possible burden on the patient’s body. This study assesses the effect of salvianolic acid B (Sal B) on the proliferation, migration, and production of collagen type III by fibroblasts, which are the most important processes in wound healing. The study was conducted on human gingival fibroblasts obtained from primary cell culture. The results showed that Sal B at a dose of 75 µg/mL increases the cell viability with significant stimulation of the cell migration as demonstrated in the wound healing assay, as well as an increase in the expression of collagen type III, which has great importance in the initial stages of wound scarring. The results obtained in the conducted studies and previous scientific reports on the antibacterial properties and low toxicity of Sal B indicate its high potential in wound healing.
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spelling pubmed-83076772021-07-25 Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model Szwedowicz, Urszula Szewczyk, Anna Gołąb, Krzysztof Choromańska, Anna Int J Mol Sci Article Despite a wide range of bactericides and antiseptics, the treatment of chronic or complicated wounds is still a major challenge for modern medicine. Topical medications are the most sought-after new agents for use as treatment. The therapeutic concentration of their active substances is easy to achieve with the lowest possible burden on the patient’s body. This study assesses the effect of salvianolic acid B (Sal B) on the proliferation, migration, and production of collagen type III by fibroblasts, which are the most important processes in wound healing. The study was conducted on human gingival fibroblasts obtained from primary cell culture. The results showed that Sal B at a dose of 75 µg/mL increases the cell viability with significant stimulation of the cell migration as demonstrated in the wound healing assay, as well as an increase in the expression of collagen type III, which has great importance in the initial stages of wound scarring. The results obtained in the conducted studies and previous scientific reports on the antibacterial properties and low toxicity of Sal B indicate its high potential in wound healing. MDPI 2021-07-20 /pmc/articles/PMC8307677/ /pubmed/34299351 http://dx.doi.org/10.3390/ijms22147728 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szwedowicz, Urszula
Szewczyk, Anna
Gołąb, Krzysztof
Choromańska, Anna
Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model
title Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model
title_full Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model
title_fullStr Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model
title_full_unstemmed Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model
title_short Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model
title_sort evaluation of wound healing activity of salvianolic acid b on in vitro experimental model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307677/
https://www.ncbi.nlm.nih.gov/pubmed/34299351
http://dx.doi.org/10.3390/ijms22147728
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