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Exploitation of Marine Molecules to Manage Alzheimer’s Disease
Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307759/ https://www.ncbi.nlm.nih.gov/pubmed/34203244 http://dx.doi.org/10.3390/md19070373 |
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author | Silva, Marisa Seijas, Paula Otero, Paz |
author_facet | Silva, Marisa Seijas, Paula Otero, Paz |
author_sort | Silva, Marisa |
collection | PubMed |
description | Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and behavioral disorders. Though the etiology of this pathology is still unknown, it is usually associated with the appearance of senile plaques and neurofibrillary tangles. The most used prophylaxis relies on anticholinesterase drugs and NMDA receptor antagonists, whose main action is to relieve symptoms and not to treat or prevent the disease. Currently, the scientific community is gathering efforts to disclose new natural compounds effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been shown to be promising candidates, and some have been proven to exert a high neuroprotection effect, constituting a large reservoir of potential drugs and nutraceutical agents. The present article attempts to describe the processes of extraction and isolation of bioactive compounds derived from sponges, algae, marine bacteria, invertebrates, crustaceans, and tunicates as drug candidates against AD, with a focus on the success of pharmacological activity in the process of finding new and effective drug compounds. |
format | Online Article Text |
id | pubmed-8307759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83077592021-07-25 Exploitation of Marine Molecules to Manage Alzheimer’s Disease Silva, Marisa Seijas, Paula Otero, Paz Mar Drugs Review Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and behavioral disorders. Though the etiology of this pathology is still unknown, it is usually associated with the appearance of senile plaques and neurofibrillary tangles. The most used prophylaxis relies on anticholinesterase drugs and NMDA receptor antagonists, whose main action is to relieve symptoms and not to treat or prevent the disease. Currently, the scientific community is gathering efforts to disclose new natural compounds effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been shown to be promising candidates, and some have been proven to exert a high neuroprotection effect, constituting a large reservoir of potential drugs and nutraceutical agents. The present article attempts to describe the processes of extraction and isolation of bioactive compounds derived from sponges, algae, marine bacteria, invertebrates, crustaceans, and tunicates as drug candidates against AD, with a focus on the success of pharmacological activity in the process of finding new and effective drug compounds. MDPI 2021-06-28 /pmc/articles/PMC8307759/ /pubmed/34203244 http://dx.doi.org/10.3390/md19070373 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Silva, Marisa Seijas, Paula Otero, Paz Exploitation of Marine Molecules to Manage Alzheimer’s Disease |
title | Exploitation of Marine Molecules to Manage Alzheimer’s Disease |
title_full | Exploitation of Marine Molecules to Manage Alzheimer’s Disease |
title_fullStr | Exploitation of Marine Molecules to Manage Alzheimer’s Disease |
title_full_unstemmed | Exploitation of Marine Molecules to Manage Alzheimer’s Disease |
title_short | Exploitation of Marine Molecules to Manage Alzheimer’s Disease |
title_sort | exploitation of marine molecules to manage alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307759/ https://www.ncbi.nlm.nih.gov/pubmed/34203244 http://dx.doi.org/10.3390/md19070373 |
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