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Nutritional Therapy in Pediatric Crohn’s Disease—Are We Going to Change the Guidelines?
In recent years, there has been a significant increase in the incidence of Crohn’s disease. Despite significant medical progress, the treatment options available today do not meet the needs of all patients. Recent reports indicate that external environmental factors, including diet, are key in the p...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307913/ https://www.ncbi.nlm.nih.gov/pubmed/34300192 http://dx.doi.org/10.3390/jcm10143027 |
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author | Matuszczyk, Malgorzata Kierkus, Jaroslaw |
author_facet | Matuszczyk, Malgorzata Kierkus, Jaroslaw |
author_sort | Matuszczyk, Malgorzata |
collection | PubMed |
description | In recent years, there has been a significant increase in the incidence of Crohn’s disease. Despite significant medical progress, the treatment options available today do not meet the needs of all patients. Recent reports indicate that external environmental factors, including diet, are key in the pathomechanism of the disease. It was proven that the so-called Western dietary pattern is associated with an increased risk of disease. In the pediatric population, exclusive enteral nutrition is the only nutritional therapy option recommended today with proven high efficacy in inducing remission. Recent publications that indicate at least comparable efficacy and significantly better tolerability of a specialised elimination diet, the Crohn’s Disease Exclusion Diet (CDED), provide the basis for a change in recommendations. This article discusses the mechanism of action, principles of use, and scientific evidence evaluating the efficacy of CDED in the treatment of children with Crohn’s disease. |
format | Online Article Text |
id | pubmed-8307913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83079132021-07-25 Nutritional Therapy in Pediatric Crohn’s Disease—Are We Going to Change the Guidelines? Matuszczyk, Malgorzata Kierkus, Jaroslaw J Clin Med Review In recent years, there has been a significant increase in the incidence of Crohn’s disease. Despite significant medical progress, the treatment options available today do not meet the needs of all patients. Recent reports indicate that external environmental factors, including diet, are key in the pathomechanism of the disease. It was proven that the so-called Western dietary pattern is associated with an increased risk of disease. In the pediatric population, exclusive enteral nutrition is the only nutritional therapy option recommended today with proven high efficacy in inducing remission. Recent publications that indicate at least comparable efficacy and significantly better tolerability of a specialised elimination diet, the Crohn’s Disease Exclusion Diet (CDED), provide the basis for a change in recommendations. This article discusses the mechanism of action, principles of use, and scientific evidence evaluating the efficacy of CDED in the treatment of children with Crohn’s disease. MDPI 2021-07-07 /pmc/articles/PMC8307913/ /pubmed/34300192 http://dx.doi.org/10.3390/jcm10143027 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Matuszczyk, Malgorzata Kierkus, Jaroslaw Nutritional Therapy in Pediatric Crohn’s Disease—Are We Going to Change the Guidelines? |
title | Nutritional Therapy in Pediatric Crohn’s Disease—Are We Going to Change the Guidelines? |
title_full | Nutritional Therapy in Pediatric Crohn’s Disease—Are We Going to Change the Guidelines? |
title_fullStr | Nutritional Therapy in Pediatric Crohn’s Disease—Are We Going to Change the Guidelines? |
title_full_unstemmed | Nutritional Therapy in Pediatric Crohn’s Disease—Are We Going to Change the Guidelines? |
title_short | Nutritional Therapy in Pediatric Crohn’s Disease—Are We Going to Change the Guidelines? |
title_sort | nutritional therapy in pediatric crohn’s disease—are we going to change the guidelines? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307913/ https://www.ncbi.nlm.nih.gov/pubmed/34300192 http://dx.doi.org/10.3390/jcm10143027 |
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