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A New Classification of the Severity of Psoriasis: What’s Moderate Psoriasis?

The purpose of this study is to propose a ranking system for the severity of psoriasis. The consensus method of selecting the indices to include and the classification of real patient profiles by an expert panel to create a gold standard of severity were used. The performance of potential cut-offs w...

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Autores principales: Salgado-Boquete, Laura, Carrascosa, José Manuel, Llamas-Velasco, Mar, Ruiz-Villaverde, Ricardo, de la Cueva, Pablo, Belinchón, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307918/
https://www.ncbi.nlm.nih.gov/pubmed/34209585
http://dx.doi.org/10.3390/life11070627
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author Salgado-Boquete, Laura
Carrascosa, José Manuel
Llamas-Velasco, Mar
Ruiz-Villaverde, Ricardo
de la Cueva, Pablo
Belinchón, Isabel
author_facet Salgado-Boquete, Laura
Carrascosa, José Manuel
Llamas-Velasco, Mar
Ruiz-Villaverde, Ricardo
de la Cueva, Pablo
Belinchón, Isabel
author_sort Salgado-Boquete, Laura
collection PubMed
description The purpose of this study is to propose a ranking system for the severity of psoriasis. The consensus method of selecting the indices to include and the classification of real patient profiles by an expert panel to create a gold standard of severity were used. The performance of potential cut-offs was evaluated to create a ranking algorithm. The combined use of PASI, BSA, and sPGA may allow the classification of the severity of psoriatic patients. The final algorithm identifies severe patients in a single step (2 out 3 are met: PASI ≥ 11 or BSA ≥ 10 or sPGA ≥ 3), while two steps are required for mild ((2 out 3 are met: PASI ≤ 3 or BSA ≤ 5 or sPGA ≤ 2) and DLQI < 5) and moderate forms (the patient does not meet 2 out 3 (PASI ≥ 11 or BSA ≥ 10 or sPGA ≥ 3) but has a DLQI ≥ 5. A ranking algorithm is presented, consisting of different measures of disease which classifies psoriatic patients into three categories: mild, moderate, and severe.
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spelling pubmed-83079182021-07-25 A New Classification of the Severity of Psoriasis: What’s Moderate Psoriasis? Salgado-Boquete, Laura Carrascosa, José Manuel Llamas-Velasco, Mar Ruiz-Villaverde, Ricardo de la Cueva, Pablo Belinchón, Isabel Life (Basel) Article The purpose of this study is to propose a ranking system for the severity of psoriasis. The consensus method of selecting the indices to include and the classification of real patient profiles by an expert panel to create a gold standard of severity were used. The performance of potential cut-offs was evaluated to create a ranking algorithm. The combined use of PASI, BSA, and sPGA may allow the classification of the severity of psoriatic patients. The final algorithm identifies severe patients in a single step (2 out 3 are met: PASI ≥ 11 or BSA ≥ 10 or sPGA ≥ 3), while two steps are required for mild ((2 out 3 are met: PASI ≤ 3 or BSA ≤ 5 or sPGA ≤ 2) and DLQI < 5) and moderate forms (the patient does not meet 2 out 3 (PASI ≥ 11 or BSA ≥ 10 or sPGA ≥ 3) but has a DLQI ≥ 5. A ranking algorithm is presented, consisting of different measures of disease which classifies psoriatic patients into three categories: mild, moderate, and severe. MDPI 2021-06-29 /pmc/articles/PMC8307918/ /pubmed/34209585 http://dx.doi.org/10.3390/life11070627 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Salgado-Boquete, Laura
Carrascosa, José Manuel
Llamas-Velasco, Mar
Ruiz-Villaverde, Ricardo
de la Cueva, Pablo
Belinchón, Isabel
A New Classification of the Severity of Psoriasis: What’s Moderate Psoriasis?
title A New Classification of the Severity of Psoriasis: What’s Moderate Psoriasis?
title_full A New Classification of the Severity of Psoriasis: What’s Moderate Psoriasis?
title_fullStr A New Classification of the Severity of Psoriasis: What’s Moderate Psoriasis?
title_full_unstemmed A New Classification of the Severity of Psoriasis: What’s Moderate Psoriasis?
title_short A New Classification of the Severity of Psoriasis: What’s Moderate Psoriasis?
title_sort new classification of the severity of psoriasis: what’s moderate psoriasis?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307918/
https://www.ncbi.nlm.nih.gov/pubmed/34209585
http://dx.doi.org/10.3390/life11070627
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