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Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation
It is well known that mast cells (MCs) initiate type I allergic reactions and inflammation in a quick response to the various stimulants, including—but not limited to—allergens, pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs). MCs highly express recep...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308013/ https://www.ncbi.nlm.nih.gov/pubmed/34203383 http://dx.doi.org/10.3390/cells10071615 |
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author | Zhang, Zhongwei Kurashima, Yosuke |
author_facet | Zhang, Zhongwei Kurashima, Yosuke |
author_sort | Zhang, Zhongwei |
collection | PubMed |
description | It is well known that mast cells (MCs) initiate type I allergic reactions and inflammation in a quick response to the various stimulants, including—but not limited to—allergens, pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs). MCs highly express receptors of these ligands and proteases (e.g., tryptase, chymase) and cytokines (TNF), and other granular components (e.g., histamine and serotonin) and aggravate the allergic reaction and inflammation. On the other hand, accumulated evidence has revealed that MCs also possess immune-regulatory functions, suppressing chronic inflammation and allergic reactions on some occasions. IL-2 and IL-10 released from MCs inhibit excessive immune responses. Recently, it has been revealed that allergen immunotherapy modulates the function of MCs from their allergic function to their regulatory function to suppress allergic reactions. This evidence suggests the possibility that manipulation of MCs functions will result in a novel approach to the treatment of various MCs-mediated diseases. |
format | Online Article Text |
id | pubmed-8308013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83080132021-07-25 Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation Zhang, Zhongwei Kurashima, Yosuke Cells Review It is well known that mast cells (MCs) initiate type I allergic reactions and inflammation in a quick response to the various stimulants, including—but not limited to—allergens, pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs). MCs highly express receptors of these ligands and proteases (e.g., tryptase, chymase) and cytokines (TNF), and other granular components (e.g., histamine and serotonin) and aggravate the allergic reaction and inflammation. On the other hand, accumulated evidence has revealed that MCs also possess immune-regulatory functions, suppressing chronic inflammation and allergic reactions on some occasions. IL-2 and IL-10 released from MCs inhibit excessive immune responses. Recently, it has been revealed that allergen immunotherapy modulates the function of MCs from their allergic function to their regulatory function to suppress allergic reactions. This evidence suggests the possibility that manipulation of MCs functions will result in a novel approach to the treatment of various MCs-mediated diseases. MDPI 2021-06-28 /pmc/articles/PMC8308013/ /pubmed/34203383 http://dx.doi.org/10.3390/cells10071615 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Zhongwei Kurashima, Yosuke Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation |
title | Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation |
title_full | Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation |
title_fullStr | Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation |
title_full_unstemmed | Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation |
title_short | Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation |
title_sort | two sides of the coin: mast cells as a key regulator of allergy and acute/chronic inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308013/ https://www.ncbi.nlm.nih.gov/pubmed/34203383 http://dx.doi.org/10.3390/cells10071615 |
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