A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis

Platelet-derived growth factor B (PDGF-B) is a mitogenic, migratory and survival factor. Cell-associated PDGF-B recruits stabilizing pericytes towards blood vessels through retention in extracellular matrix. We hypothesized that the genetic ablation of cell-associated PDGF-B by retention motif delet...

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Detalles Bibliográficos
Autores principales: Tillie, Renée J. H. A., Theelen, Thomas L., van Kuijk, Kim, Temmerman, Lieve, de Bruijn, Jenny, Gijbels, Marion, Betsholtz, Christer, Biessen, Erik A. L., Sluimer, Judith C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308020/
https://www.ncbi.nlm.nih.gov/pubmed/34359916
http://dx.doi.org/10.3390/cells10071746

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