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Indole- and Pyrazole-Glycyrrhetinic Acid Derivatives as PTP1B Inhibitors: Synthesis, In Vitro and In Silico Studies

Regulating insulin and leptin levels using a protein tyrosine phosphatase 1B (PTP1B) inhibitor is an attractive strategy to treat diabetes and obesity. Glycyrrhetinic acid (GA), a triterpenoid, may weakly inhibit this enzyme. Nonetheless, semisynthetic derivatives of GA have not been developed as PT...

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Detalles Bibliográficos
Autores principales:	De-la-Cruz-Martínez, Ledy, Duran-Becerra, Constanza, González-Andrade, Martin, Páez-Franco, José C., Germán-Acacio, Juan Manuel, Espinosa-Chávez, Julio, Torres-Valencia, J. Martin, Pérez-Villanueva, Jaime, Palacios-Espinosa, Juan Francisco, Soria-Arteche, Olivia, Cortés-Benítez, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308021/ https://www.ncbi.nlm.nih.gov/pubmed/34299651 http://dx.doi.org/10.3390/molecules26144375

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